Zobrazeno 1 - 10
of 18
pro vyhledávání: '"David M McDonald"'
Publikováno v:
Frontiers in Chemistry, Vol 3 (2015)
Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells. These glycans are known as tumor-associated carbohydrate ant
Externí odkaz:
https://doaj.org/article/40f35bbe8670486bbba7617052b34a46
Autor:
Edward A. deRamon, Venkata R. Sabbasani, Matthew D. Streeter, Yannan Liu, Timothy R. Newhouse, David M. McDonald, David A. Spiegel
Publikováno v:
Journal of the American Chemical Society. 144:21843-21847
Pentosinane is a structurally complex nonenzymatic post-translational modification of proteins believed to be present in all living things. It falls into the category of advanced glycation end products (AGEs) and is structurally related to the other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ee075774f44323d7a3b9712808c31
https://doi.org/10.1021/jacs.2c09626
https://doi.org/10.1021/jacs.2c09626
Autor:
David Spiegel, Jason Ray, David M McDonald, Viswanathan Muthusamy, Rebecca Howell, Angela Z Gong, David Caianiello, Mengwen Zhang, Jake C Swartzel, Venkata R. Sabbasani, Egor Chirkin, Emily M J Branham
Publikováno v:
Nature Chemical Biology. 17:947-953
Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy. Most TPD technologies use the ubiquitin-proteasome system, and are therefore limited to targeting intracellular proteins. To address this limitation, we developed a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::574d051ff5b7bfbaf233fa5c99bf18d8
https://doi.org/10.1038/s41589-021-00851-1
https://doi.org/10.1038/s41589-021-00851-1
Autor:
David M McDonald, Sheldon Rowan, Matthew D. Streeter, David Spiegel, Allen Taylor, Jonathan Volkin, Jonathan Clark, Jason Ray
Publikováno v:
ACS Chemical Biology. 15:2655-2661
Although there is ample evidence that the advanced glycation end-product (AGE) glucosepane contributes to age-related morbidities and diabetic complications, the impact of glucosepane modifications on proteins has not been extensively explored due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286bf00c9139f6637aa5909847c88f81
https://doi.org/10.1021/acschembio.0c00093
https://doi.org/10.1021/acschembio.0c00093
Autor:
Vicki A. Stanojevic, Warwick J. Britton, Anneliese S. Ashhurst, Cameron C Hanna, Richard J. Payne, David M. McDonald
Publikováno v:
Journal of Medicinal Chemistry. 62:8080-8089
Tuberculosis (TB) remains a staggering burden on global public health. Novel preventative tools are desperately needed to reach the targets of the WHO post-2015 End-TB Strategy. Peptide or protein-based subunit vaccines offer potential as safe and ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f880ade72696b0908990ad7579ea95
https://doi.org/10.1021/acs.jmedchem.9b00832
https://doi.org/10.1021/acs.jmedchem.9b00832
Autor:
Jason Ray, David M McDonald, Eli Chapman, David Spiegel, Marissa N. Trujillo, Erin Q. Jennings, James J. Galligan, Christopher J. Zerio
Publikováno v:
Chembiochem
Post-translational modifications (PTMs) play roles in both physiological and pathophysiological processes through the regulation of enzyme structure and function. We recently identified a novel PTM, lactoylLys, derived through a non-enzymatic mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb020a21e4fdf1de383c12fd60eef14
https://europepmc.org/articles/PMC8205944/
https://europepmc.org/articles/PMC8205944/
Autor:
Richard J. Payne, David M. McDonald, Scott N. Byrne, Anneliese S. Ashhurst, Leo Corcilius, Cameron C Hanna
Publikováno v:
ACS Chemical Biology. 13:3279-3285
Access to lipopeptide-based vaccines for immunological studies remains a significant challenge owing to the amphipathic nature of the molecules, which makes them difficult to synthesize and purify to homogeneity. Here, we describe the application of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b13a2fb41ae68f57492c472ab27dd2f
https://doi.org/10.1021/acschembio.8b00675
https://doi.org/10.1021/acschembio.8b00675
Autor:
Anneliese S, Ashhurst, David M, McDonald, Cameron C, Hanna, Vicki A, Stanojevic, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 62(17)
Tuberculosis (TB) remains a staggering burden on global public health. Novel preventative tools are desperately needed to reach the targets of the WHO post-2015 End-TB Strategy. Peptide or protein-based subunit vaccines offer potential as safe and ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7ed6f80628f47d459b03168794915db
https://pubmed.ncbi.nlm.nih.gov/31373811
https://pubmed.ncbi.nlm.nih.gov/31373811
Autor:
Gary M. Halliday, Felix Marsh-Wakefield, Seri Narti Edayu Sarchio, Clare Beaugie, Scott N. Byrne, David M. McDonald, Richard A. Scolyer
Publikováno v:
Journal of Investigative Dermatology. 134(4):1091-1100
One way sunlight causes skin cancer is by suppressing anti-tumor immunity. A major mechanism involves altering mast cell migration via the C-X-C motif chemokine receptor 4–C-X-C motif chemokine ligand 12 (CXCR4-CXCL12) chemokine pathway. We have di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4ed0d01e596de844651bef2d776d24
Autor:
Brendan L. Wilkinson, David M. McDonald, Richard J. Payne, Scott N. Byrne, Morten Thaysen-Andersen, Leo Corcilius
Publikováno v:
Chem. Commun.. 50:10273-10276
We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0ecc30115f8d8563c20a8711238347
https://doi.org/10.1039/c4cc03510k
https://doi.org/10.1039/c4cc03510k