Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David M Markusic"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Therapeutic gene transfer holds the promise of providing lasting therapies and even cures for diseases that were previously untreatable or for which only temporary or suboptimal treatments were available. For some time, clinical gene therapy was char
Externí odkaz:
https://doaj.org/article/3869457b10a644a5963e0b8ed9e48b6e
Autor:
Irene Zolotukhin, David M Markusic, Brett Palaschak, Brad E Hoffman, Meera A Srikanthan, Roland W Herzog
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Hemophilia A and B are coagulation disorders resulting from the loss of functional coagulation factor VIII (FVIII) or factor IX proteins, respectively. Gene therapy for hemophilia with adeno-associated virus vectors has shown efficacy in hemophilia B
Externí odkaz:
https://doaj.org/article/cc6eb2caf37342bfa894aa969350dfa7
Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia
Autor:
Debalina Sarkar, Moanaro Biswas, Gongxian Liao, Howard R Seay, George Q Perrin, David M Markusic, Brad E Hoffman, Todd M Brusko, Cox Terhorst, Roland W Herzog
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Adoptive cell therapy utilizing ex vivo expanded polyclonal CD4+CD25+FOXP3+ regulatory T cells (Treg) is in use in clinical trials for the treatment of type 1 diabetes and prevention of graft versus host disease in bone marrow transplantation. Here,
Externí odkaz:
https://doaj.org/article/6e375a589b1f4e66989e48a1fe42c693
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Gene replacement therapies, like organ and cell transplantation, are likely to introduce neoantigens that elicit rejection via humoral and/or effector T-cell immune responses. Nonetheless, thanks to an ever-growing body of preclinical studies; it is
Externí odkaz:
https://doaj.org/article/3c589ab0a9ce47528d80876ecd846c6b
Autor:
Miguel Gonzalez-Visiedo, Roland W. Herzog, Maite Munoz-Melero, Sophia A. Blessinger, Joan M. Cook-Mills, Henry Daniell, David M. Markusic
Publikováno v:
Viruses, Vol 16, Iss 7, p 1125 (2024)
Food allergy (FA) is estimated to impact up to 10% of the population and is a growing health concern. FA results from a failure in the mucosal immune system to establish or maintain immunological tolerance to innocuous dietary antigens, IgE productio
Externí odkaz:
https://doaj.org/article/9a57a1000a05483fb8e70f3d617faad2
Autor:
Brandon K Sack, Sherin Merchant, David M Markusic, Amit C Nathwani, Andrew M Davidoff, Barry J Byrne, Roland W Herzog
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37671 (2012)
The major complication in the treatment of hemophilia A is the development of neutralizing antibodies (inhibitors) against factor VIII (FVIII). The current method for eradicating inhibitors, termed immune tolerance induction (ITI), is costly and prot
Externí odkaz:
https://doaj.org/article/1439e802b7f345b58edbf0b23d5a60d6
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9974 (2010)
BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as erythropoietin. Because overexpression of erythropoietin can be toxic, regulated expression is needed. Doxycycline inducible vectors can regulate expre
Externí odkaz:
https://doaj.org/article/c7e1a5304f664a31890dd242634d652d
Autor:
Ashley T Martino, Sushrusha Nayak, Brad E Hoffman, Mario Cooper, Gongxian Liao, David M Markusic, Barry J Byrne, Cox Terhorst, Roland W Herzog
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6376 (2009)
BACKGROUND:Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for s
Externí odkaz:
https://doaj.org/article/76198aa8a6f348b6a4dfe6565a993d47
B cell focused transient immune suppression protocol for efficient AAV readministration to the liver
Autor:
Jyoti Rana, Roland W. Herzog, Maite Muñoz-Melero, Kentaro Yamada, Sandeep R.P. Kumar, Anh K. Lam, David M. Markusic, Dongsheng Duan, Cox Terhorst, Barry J. Byrne, Manuela Corti, Moanaro Biswas
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101216- (2024)
Adeno-associated virus (AAV) vectors are used for correcting multiple genetic disorders. Although the goal is to achieve lifelong correction with a single vector administration, the ability to redose would enable the extension of therapy in cases in
Externí odkaz:
https://doaj.org/article/dbfee83096ee41878357669ddf1b4522
Autor:
Miguel Gonzalez-Visiedo, Xin Li, Maite Munoz-Melero, Michael D. Kulis, Henry Daniell, David M. Markusic
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 309-322 (2022)
Immunotherapies for patients with food allergy have shown some success in limiting allergic responses. However, these approaches require lengthy protocols with repeated allergen dosing and patients can relapse following discontinuation of treatment.
Externí odkaz:
https://doaj.org/article/5eb6814f4187470190ad8278d7d9c90c