Zobrazeno 1 - 10
of 488
pro vyhledávání: '"David M Livermore"'
Autor:
Andrew M Wilson, Allan B Clark, Anthony Cahn, Edwin R Chilvers, William Fraser, Matthew Hammond, David M Livermore, Toby M Maher, Helen Parfrey, Ann Marie Swart, Susan Stirling, David Thickett, Moira Whyte
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 8, Iss 9 (2021)
Background: Idiopathic pulmonary fibrosis is an irreversible fibrosing lung disorder with a poor prognosis. Current treatments slow the rate of decline in lung function and may influence survival, but they have a significant side-effect profile and s
Externí odkaz:
https://doaj.org/article/eac2fcbe27b44ad5b2fc818f25be3374
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/c022d6a0cccf42bab4f20b78f4813a5f
Autor:
Matthew Hammond, Allan B. Clark, Anthony P. Cahn, Edwin R. Chilvers, William Duncan Fraser, David M. Livermore, Toby M. Maher, Helen Parfrey, Ann Marie Swart, Susan Stirling, David Thickett, Moira Whyte, Andrew Wilson
Publikováno v:
Trials, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background We hypothesise, based upon the findings from our previous trial, that the addition of co-trimoxazole to standard therapy is beneficial to patients with moderate to severe idiopathic pulmonary fibrosis (IPF). We aim to investigate
Externí odkaz:
https://doaj.org/article/cbc90e7411364a5a8bb2ccb0d095d0b6
Autor:
Ahuva Cern, Yaelle Bavli, Atara Hod, Daniel Zilbersheid, Shazad Mushtaq, Ayelet Michael-Gayego, Dinorah Barasch, Yael Feinstein Rotkopf, Allon E. Moses, David M. Livermore, Yechezkel Barenholz
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2186 (2021)
Antibiotic resistance is a global health threat. There are a few antibiotics under development, and even fewer with new modes of action and no cross-resistance to established antibiotics. Accordingly, reformulation of old antibiotics to overcome resi
Externí odkaz:
https://doaj.org/article/88f8dd726fd14c7a8535af5349bf0ad5
Aztreonam/avibactam is being developed on the rationale that aztreonam evades metallo-β-lactamases (MBLs) whilst avibactam protects aztreonam against co-produced serine β-lactamases. This study measured the activity of aztreonam/avibactam against M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf38a0725e5c2d961585330d6b519a3
https://ueaeprints.uea.ac.uk/id/eprint/91357/
https://ueaeprints.uea.ac.uk/id/eprint/91357/
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:1916-1922
Objectives Combinations of PBP3-active β-lactams with developmental diazabicyclooctanes (DBOs), e.g. zidebactam, remain active against many MBL producers via an enhancer effect. We explored how this activity is affected by inoculum. Materials and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06094fed32d060f6572af2251ee1f136
https://doi.org/10.1093/jac/dkac108
https://doi.org/10.1093/jac/dkac108
Autor:
Virve I, Enne, Alp, Aydin, Rossella, Baldan, Dewi R, Owen, Hollian, Richardson, Federico, Ricciardi, Charlotte, Russell, Brenda O, Nomamiukor-Ikeji, Ann-Marie, Swart, Juliet, High, Antony, Colles, Julie, Barber, Vanya, Gant, David M, Livermore, Justin, O'Grady, David, Turner
BackgroundCulture-based microbiological investigation of hospital-acquired or ventilator-associated pneumonia (HAP or VAP) is insensitive, with aetiological agents often unidentified. This can lead to excess antimicrobial treatment of patients with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f2183271059fc2b6dff702a0b5dc2f
https://ueaeprints.uea.ac.uk/id/eprint/82615/
https://ueaeprints.uea.ac.uk/id/eprint/82615/
Background Secondary healthcare will remain pressured for some years, both because SARS-CoV-2 will circulate as a nosocomial pathogen, and owing to backlogs of patients awaiting delayed elective procedures. These stresses will drive the use of Outpat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8134e23f4a434dd79571b7da89a14f8b
https://ueaeprints.uea.ac.uk/id/eprint/87067/
https://ueaeprints.uea.ac.uk/id/eprint/87067/
Autor:
David M. Livermore
Publikováno v:
JAC-Antimicrobial Resistance
Antibiotics underpin the ‘modern medicine’ that has increased life expectancy, leading to societies with sizeable vulnerable elderly populations who have suffered disproportionately during the current COVID-19 pandemic. Governments have responded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43733e89670256d7331c5e6388f15091
http://europepmc.org/articles/PMC8210049
http://europepmc.org/articles/PMC8210049
Modern medicine is threatened by the rising tide of antimicrobial resistance, especially among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β-lactamases. The penicillin and cephalosporin ascendancies were, in thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e4322e700f5dcdbb9281007088c395
http://hdl.handle.net/10044/1/98647
http://hdl.handle.net/10044/1/98647