Zobrazeno 1 - 10
of 242
pro vyhledávání: '"David M Kranz"'
Autor:
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine
Externí odkaz:
https://doaj.org/article/861817e037174ed8a392e07d910f8aaf
Autor:
David M Kranz, Michael J White, Mao Li, Maximilian O Schaettler, Rupen Desai, Anthony Z Wang, Alexandra J Livingstone, Dale K Kobayashi, Andrew T Coxon, Jay A Bowman-Kirigin, Connor J Liu, Diane E Bender, Tanner M Johanns, Gavin P Dunn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Adoptive cellular therapies with chimeric antigen receptor T cells have revolutionized the treatment of some malignancies but have shown limited efficacy in solid tumors such as glioblastoma and face a scarcity of safe therapeutic targets.
Externí odkaz:
https://doaj.org/article/67ba15afade74b8a9caa7534c5ef5ce0
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135986 (2015)
Staphylococcal and streptococcal exotoxins, also known as superantigens, mediate a range of diseases including toxic shock syndrome, and they exacerbate skin, pulmonary and systemic infections caused by these organisms. When present in food sources t
Externí odkaz:
https://doaj.org/article/7974c13103904e4580affe1d8f80aa58
Autor:
Vesna Tosic, Diana L Thomas, David M Kranz, Jia Liu, Grant McFadden, Joanna L Shisler, Amy L MacNeill, Edward J Roy
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109801 (2014)
Myxoma virus, a rabbit poxvirus, can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit-specific pathogen, and is thought to be safe as a therapeutic agent in all non-rabbit hosts tested including mice and humans.
Externí odkaz:
https://doaj.org/article/2160641e065949cda99562565d896074
Autor:
Jianrong L Low, Anneta Naidoo, Gladys Yeo, Adam J Gehring, Zi Zong Ho, Yin Hoe Yau, Susana G Shochat, David M Kranz, Antonio Bertoletti, Gijsbert M Grotenbreg
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51397 (2012)
Class I Major Histocompatibility Complex (MHC) molecules evolved to sample degraded protein fragments from the interior of the cell, and to display them at the surface for immune surveillance by CD8(+) T cells. The ability of these lymphocytes to ide
Externí odkaz:
https://doaj.org/article/f2d75e68c2454673b68f16005f836244
Autor:
Petra L Kohler, Seth D Greenwood, Suba Nookala, Malak Kotb, David M Kranz, Patrick M Schlievert
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41157 (2012)
Staphylococcus aureus produces superantigens (SAgs) that bind and cross-link T cells and APCs, leading to activation and proliferation of immune cells. SAgs bind to variable regions of the β-chains of T cell receptors (Vβ-TCRs), and each SAg binds
Externí odkaz:
https://doaj.org/article/fbc2fe7868724b3aa93e39acbd7679a5
Despite progress in adoptive T-cell therapies, the identification of targets remains a challenge. Although chimeric antigen receptors recognize cell-surface antigens, T-cell receptors (TCR) have the advantage that they can target the array of intrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d017c946731750f4b19a48cc234e1b85
https://doi.org/10.1158/2326-6066.c.6549883.v1
https://doi.org/10.1158/2326-6066.c.6549883.v1
Supplementary Table S1: Predicted HLA-A2 binding MART-1 homologues present in human and mouse proteomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6dd3c869840be7a972c69bbc18bfc8
https://doi.org/10.1158/2326-6066.22542340.v1
https://doi.org/10.1158/2326-6066.22542340.v1
Supplementary Figure S3: Reactivity of T1 or RD1 TCR transduced CD8+ T cells with human peptides containing central "GIG" motif.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ac734149c209a075ab5c2180b17f81
https://doi.org/10.1158/2326-6066.22542343.v1
https://doi.org/10.1158/2326-6066.22542343.v1
Autor:
David M. Kranz, Thomas F. Gajewski, Yuanyuan Zha, Marlies V. Hager, Daniel M. Yoakum, Scott D. Anderson, Dylan T. Blaha
Mutated peptides (neoantigens) from a patient's cancer genome can serve as targets for T-cell immunity, but identifying which peptides can be presented by an MHC molecule and elicit T cells has been difficult. Although algorithms that predict MHC bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3665929f528251438ab6c63863773eaf
https://doi.org/10.1158/2326-6066.c.6547978.v1
https://doi.org/10.1158/2326-6066.c.6547978.v1