Zobrazeno 1 - 10
of 141
pro vyhledávání: '"David M Kern"'
Autor:
Kimberly A Dolan, Mandira Dutta, David M Kern, Abhay Kotecha, Gregory A Voth, Stephen G Brohawn
Publikováno v:
eLife, Vol 11 (2022)
SARS-CoV-2 encodes four structural proteins incorporated into virions, spike (S), envelope (E), nucleocapsid (N), and membrane (M). M plays an essential role in viral assembly by organizing other structural proteins through physical interactions and
Externí odkaz:
https://doaj.org/article/e30b73ef0ebc4151b16b3ceff1fe0988
Publikováno v:
eLife, Vol 9 (2020)
Cation-chloride-cotransporters (CCCs) catalyze transport of Cl- with K+ and/or Na+across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function. C
Externí odkaz:
https://doaj.org/article/8300ff7f74fd4eb08da877bf81cfb4cb
Publikováno v:
eLife, Vol 8 (2019)
Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we pre
Externí odkaz:
https://doaj.org/article/2fdb45c7a2014b01af29964dd29b4eb1
Publikováno v:
eLife, Vol 6 (2017)
Chromosome segregation requires robust interactions between the macromolecular kinetochore structure and dynamic microtubule polymers. A key outstanding question is how kinetochore-microtubule attachments are modulated to ensure that bi-oriented atta
Externí odkaz:
https://doaj.org/article/3d798a85c8444b1e9ebc65694cb62176
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionResults of retrospective studies examining the relationship between prolactin increasing antipsychotics and incident breast cancer have been inconsistent. This study assessed the association between use of high prolactin increasing antips
Externí odkaz:
https://doaj.org/article/4c599318a5be4181aa9cf067055979e8
Autor:
Yi Chai, Kenneth K. C. Man, Hao Luo, Carmen Olga Torre, Yun Kwok Wing, Joseph F. Hayes, David P. J. Osborn, Wing Chung Chang, Xiaoyu Lin, Can Yin, Esther W. Chan, Ivan C. H. Lam, Stephen Fortin, David M. Kern, Dong Yun Lee, Rae Woong Park, Jae-Won Jang, Jing Li, Sarah Seager, Wallis C. Y. Lau, Ian C. K. Wong
Publikováno v:
Epidemiology and Psychiatric Sciences, Vol 33 (2024)
Abstract Aims Population-wide restrictions during the COVID-19 pandemic may create barriers to mental health diagnosis. This study aims to examine changes in the number of incident cases and the incidence rates of mental health diagnoses during the C
Externí odkaz:
https://doaj.org/article/06d9737b96e4437897447ac610afa4aa
Autor:
David M. Kern, Rachel E. Teneralli, Christopher M. Flores, Gayle M. Wittenberg, James P. Gilbert, M. Soledad Cepeda
Publikováno v:
Psychiatric Research and Clinical Practice, Vol 4, Iss 1, Pp 12-20 (2022)
Objective To systematically identify novel pharmacological strategies for preventing or treating post‐traumatic stress disorder (PTSD) by leveraging large‐scale analysis of real‐world observational data. Methods Using a self‐controlled study
Externí odkaz:
https://doaj.org/article/bd6ca9d67bf74e66a848765def5716e3
Autor:
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated li
Externí odkaz:
https://doaj.org/article/f4d1fee19c624c0a9f1b40ef56f78e04
Autor:
Yiting Wang, Laura L. Hester, Jennifer Lofland, Shawn Rose, Chetan S. Karyekar, David M. Kern, Margaret Blacketer, Kourtney Davis, Kimberly Shields-Tuttle
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Objective To provide current estimates of the number of patients with prevalent systemic lupus erythematosus (SLE) by major health insurance types in the US and to describe patient characteristics. Four large US health insurance claims datab
Externí odkaz:
https://doaj.org/article/4f3f3ff6bc46415793a20559ff76f219
Publikováno v:
BMC Psychiatry, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide attempt (SI/SA). Methods Patients with SI/SA were identified from a large US-
Externí odkaz:
https://doaj.org/article/edb39b9d3c874f6fa91e5d990465357d