Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David M Kepecs"'
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0144640 (2016)
Pharmacological inhibition of the proximal tubular sodium-glucose linked cotransporter-2 (SGLT2) leads to glycosuria in both diabetic and non-diabetic settings. As a consequence of their ability to modulate tubuloglomerular feedback, SGLT2 inhibitors
Externí odkaz:
https://doaj.org/article/14a928dc77ee42b69a4a48532a005256
Publikováno v:
Canadian Journal of Emergency Medicine. 23:847-849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4aeb27d1bf65cd46d49c289f46e74b5
https://doi.org/10.1007/s43678-021-00186-9
https://doi.org/10.1007/s43678-021-00186-9
Publikováno v:
The American Journal of Pathology. 188:2763-2773
The excessive accumulation of extracellular matrix material in the kidney is a histopathologic hallmark of diabetic kidney disease that correlates closely with declining function. Although considerable research has focused on the role of profibrotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60403df61567b8a01503a7ba02cba31d
https://doi.org/10.1016/j.ajpath.2018.08.017
https://doi.org/10.1016/j.ajpath.2018.08.017
Publikováno v:
Canadian Journal of Kidney Health and Disease
Canadian Journal of Kidney Health and Disease, Vol 5 (2018)
Canadian Journal of Kidney Health and Disease, Vol 5 (2018)
One of the principal mechanisms by which illness can affect driving safety is by impairing cognition. Nevertheless, despite the substantial evidence demonstrating cognitive impairment in chronic kidney disease (CKD), little is known about the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed690597259df33f3828efb9fb16044
https://pubmed.ncbi.nlm.nih.gov/29977582
https://pubmed.ncbi.nlm.nih.gov/29977582
Publikováno v:
The Journal of arthroplasty. 32(6)
Background Total hip arthroplasty revision for a fractured ceramic bearing is rare but offers unique challenges. The purpose of this review was to provide a summary of existing literature on fractured ceramic bearings. Methods Two authors performed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a07da5f2473dd6b3adba9d79569edc0
https://pubmed.ncbi.nlm.nih.gov/28189439
https://pubmed.ncbi.nlm.nih.gov/28189439
Autor:
Yanling Zhang, Kerri Thai, Darren A. Yuen, Richard E. Gilbert, David M. Kepecs, Kim A. Connelly
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System: JRAAS
Journal of the Renin-Angiotensin-Aldosterone System, Vol 17 (2016)
Journal of the Renin-Angiotensin-Aldosterone System, Vol 17 (2016)
Hypothesis/introduction:Renal fibrovascular injury often persists in chronic kidney disease patients treated with renin-angiotensin system blockers. Intriguingly, early outgrowth cell-derived factor infusion also inhibits chronic renal injury. We sou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1de3c4f83d77d7f266e6feabb1466d1
https://pubmed.ncbi.nlm.nih.gov/27638853
https://pubmed.ncbi.nlm.nih.gov/27638853
Autor:
Richard E. Gilbert, David M. Kepecs, Kerri Thai, Andras Kapus, Kim A. Connelly, Yanling Zhang, Xinglin Wu
Publikováno v:
The American journal of pathology. 187(1)
Most forms of chronic, progressive kidney disease are characterized by fibrosis whereby the prototypical prosclerotic growth factor, transforming growth factor β (TGF-β), is thought to play a pivotal role. With the recent understanding that TGF-β'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df3e1d6a7241bce3326431a56f5f482
https://pubmed.ncbi.nlm.nih.gov/27993241
https://pubmed.ncbi.nlm.nih.gov/27993241
Autor:
David M. Kepecs, Suzanne L. Advani, Yanling Zhang, Darren A. Yuen, Richard E. Gilbert, Kerri Thai, Kim A. Connelly, Andrew Advani, M. Golam Kabir
Publikováno v:
Diabetes
Cell therapy has been extensively investigated in heart disease but less so in the kidney. We considered whether cell therapy also might be useful in diabetic kidney disease. Cognizant of the likely need for autologous cell therapy in humans, we soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883e7c098a71f2d9ee89c95362df1bf1
https://doi.org/10.2337/db11-1365
https://doi.org/10.2337/db11-1365
Autor:
Suzanne L. Advani, Darren A. Yuen, Richard E. Gilbert, Kim A. Connelly, Yanling Zhang, Eleftherios P. Diamandis, David M. Kepecs, Michael V. Sefton, Kerri Thai, Hari Kosanam
Publikováno v:
Tissue engineering. Part A. 21(13-14)
Cell-based regenerative therapies offer a new alternative approach to the treatment of chronic disease. Specifically, studies by our laboratory and others have shown that a subpopulation of cells derived from the bone marrow, known as early outgrowth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb9de384444c86f0c27089f6b75689b
https://pubmed.ncbi.nlm.nih.gov/25661544
https://pubmed.ncbi.nlm.nih.gov/25661544
Autor:
Yanling Zhang, David M. Kepecs, Kerri Thai, Carolyn L. Cummins, Stephanie A. Schroer, Richard E. Gilbert, Suzanne L. Advani, Minna Woo
Publikováno v:
Diabetologia. 58(4)
Nutrient overabundance and diminished physical activity underlie the epidemic of obesity and its consequences of insulin resistance and type 2 diabetes. These same phenomena, obesity and insulin resistance, are also observed in mammals as they ready
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a516ca795ff363012747955eecf63e3
https://pubmed.ncbi.nlm.nih.gov/25563725
https://pubmed.ncbi.nlm.nih.gov/25563725