Prior exposure to inhaled allergen enhances anti-viral immunity and T cell priming by dendritic cells.

Autor: Debbie C P Lee, Neil Q Tay, Marini Thian, Nayana Prabhu, Kazuki Furuhashi, David M Kemeny

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190063 (2018)

Influenza and asthma are two of the major public health concerns in the world today. During the 2009 influenza pandemic asthma was found to be the commonest comorbid illness of patients admitted to hospital. Unexpectedly, it was also observed that as

Externí odkaz: https://doaj.org/article/f5fcf46f3c5847f0a1ecea640542dcad

Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection.

Autor: Richard J Betts, Adrian W S Ho, David M Kemeny

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27849 (2011)

Foxp3⁺CD4⁺ regulatory T cells represent a T cell subset with well-characterized immunosuppressive effects during immune homeostasis and chronic infections, and there is emerging evidence to suggest these cells temper pulmonary inflammation in res

Externí odkaz: https://doaj.org/article/34a8023c91f7401a8be6ee9e31d28322

Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3

Autor: Antonio Vidal-Puig, Huipeng Jiao, Henry Yang, Chin Wen Png, Stephan Gasser, Ying Li, Yongliang Zhang, Mark Campbell, Asim Shabbir, David M. Kemeny, Jing Guo, José Manuel Fernández-Real, Sam Virtue, José María Moreno-Navarrete, Jian Yi Gerald Goie, Peng Tang, Yen Leong Chua

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2021, vol. 28, p. 3022-3035
Articles publicats (D-CM)
DUGiDocs – Universitat de Girona
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Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the role of IRF3 in obesity and obesity-associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4143644964234e94a730df6c38b0be07
https://www.repository.cam.ac.uk/handle/1810/330187

Priming with high and low respiratory allergen dose induces differential CD4+ T helper type 2 cells and IgE/IgG1 antibody responses in mice

Autor: Yen Leong Chua, David M. Kemeny, Kenneth H. S. Wong, Ka H. Liong, Debbie C. P. Lee, Kazuki Furuhashi, Qian Zhou, Paul Edward Hutchinson, Guo H. Teo

Publikováno v: Immunology. 151:227-238

Sensitization of allergic patients normally takes place over several years and is the result of repeated exposure to low levels of allergen. Most mouse asthma models use a high dose of allergen administered over a short period. We have investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::897d93148b0117dd4b4c338ebefbf24f
https://doi.org/10.1111/imm.12726

GM-CSF–Licensed CD11b+ Lung Dendritic Cells Orchestrate Th2 Immunity to Blomia tropicalis

Autor: Veronique Angeli, David M. Kemeny, Kenneth H. S. Wong, Qian Zhou, Fiona H. S. Wong, Adrian W. S. Ho, Andreas Schlitzer, Yen Leong Chua, Florent Ginhoux, Yafang Tang, Alessandra Mortellaro

Publikováno v: The Journal of Immunology. 193:496-509

The Blomia tropicalis dust mite is prevalent in tropical and subtropical regions of the world. Although it is a leading cause of asthma, little is known how it induces allergy. Using a novel murine asthma model induced by intranasal exposure to B. tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaefb29ef2053636c452e03e08d90665
https://doi.org/10.4049/jimmunol.1303138