Zobrazeno 1 - 10
of 691
pro vyhledávání: '"David M Kaye"'
Autor:
Vishal Goel, Jason E Bloom, Luke Dawson, Anita Shirwaiker, Stephen Bernard, Ziad Nehme, Daniel Donner, Caroline Hauw-Berlemont, Aurélie Vilfaillot, William Chan, David M Kaye, Christian Spaulding, Dion Stub
Publikováno v:
Resuscitation Plus, Vol 14, Iss , Pp 100381- (2023)
Aim: The role of early coronary angiography (CAG) in the evaluation of patients presenting with out of hospital cardiac arrest (OHCA) and no ST-elevation myocardial infarction (STE) pattern on electrocardiogram (ECG) has been subject to considerable
Externí odkaz:
https://doaj.org/article/1c67b0ff8ea84d67aed3747e170a17c6
Autor:
Shane Nanayakkara, Sam Fogarty, Michael Tremeer, Kelvin Ross, Brent Richards, Christoph Bergmeir, Sheng Xu, Dion Stub, Karen Smith, Mark Tacey, Danny Liew, David Pilcher, David M Kaye
Publikováno v:
PLoS Medicine, Vol 15, Iss 11, p e1002709 (2018)
BackgroundResuscitated cardiac arrest is associated with high mortality; however, the ability to estimate risk of adverse outcomes using existing illness severity scores is limited. Using in-hospital data available within the first 24 hours of admiss
Externí odkaz:
https://doaj.org/article/f46df3f552f249bc97d746a64d2c556e
Publikováno v:
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol 12 (2018)
Background and objective: Over 2000 genotypes in the cystic fibrosis (CF) gene have been described. These genotypic differences result in variable clinical manifestations of CF, with severity of disease dependent on CF transmembrane conductance (CFTR
Externí odkaz:
https://doaj.org/article/098b0547120e440bb80efe1249a20b1d
Publikováno v:
Clinical Medicine Insights: Cardiology, Vol 12 (2018)
Heart failure is highly prevalent with more than 50% of cases being patients with a preserved ejection fraction (HFPEF), a figure that is projected to increase due to the changing risk factor landscape, in particular the ageing population. Overall mo
Externí odkaz:
https://doaj.org/article/38956878ae9e489bae85b232562ec171
Autor:
Po-Yin Chu, Ken Walder, Duncan Horlock, David Williams, Erin Nelson, Melissa Byrne, Karin Jandeleit-Dahm, Paul Zimmet, David M Kaye
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133616 (2015)
Heart failure (HF) is an increasingly recognized complication of diabetes. Cardiac fibrosis is an important causative mechanism of HF associated with diabetes. Recent data indicate that inflammation may be particularly important in the pathogenesis o
Externí odkaz:
https://doaj.org/article/2017589b6579474a951689c4da01ae7c
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131424 (2015)
Augmenting endothelial specific transport of the nitric oxide precursor L-arginine via cationic amino acid transporter-1 (CAT1) can prevent obesity related hypertension. We tested the hypotheses that CAT1 overexpression prevents obesity-induced hyper
Externí odkaz:
https://doaj.org/article/d4065e0157794a5abadbfe65e4b14948
Autor:
Jennifer Zhou, Shane Nanayakkara, Rozanne Johnston, Ellen Gardner, Nay Min Htun, Sonny Palmer, Samer Noaman, Liam Guiney, David M. Kaye, Antony S. Walton, Dion Stub
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 55, Iss , Pp 101561- (2024)
Background: Socioeconomic status (SES) is an important determinant of healthcare outcomes in many settings, but few studies have evaluated the impact of SES among patients with aortic stenosis (AS). We sought to explore the association between SES an
Externí odkaz:
https://doaj.org/article/7ad87f019ca5405e8f38c86de2cce054
Autor:
David Williams, Kylie M Venardos, Melissa Byrne, Mandar Joshi, Duncan Horlock, Nicholas T Lam, Paul Gregorevic, Sean L McGee, David M Kaye
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104643 (2014)
BackgroundImpaired mitochondrial function is fundamental feature of heart failure (HF) and myocardial ischemia. In addition to the effects of heightened oxidative stress, altered nitric oxide (NO) metabolism, generated by a mitochondrial NO synthase,
Externí odkaz:
https://doaj.org/article/f11909e9fbd049feb59ddde30b0a8a64
Autor:
Tanya L Medley, Milena Furtado, Nicholas T Lam, Rejhan Idrizi, David Williams, Paul J Verma, Mauro Costa, David M Kaye
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80280 (2013)
BackgroundDisturbances in oxygen levels have been found to impair cardiac organogenesis. It is known that stem cells and differentiating cells may respond variably to hypoxic conditions, whereby hypoxia may enhance stem cell pluripotency, while diffe
Externí odkaz:
https://doaj.org/article/31b2bbdba9884fb7b07f61bcbf04b3ec
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61840 (2013)
AIMS/HYPOTHESIS: Impaired L-arginine transport has been reported in cardiovascular diseases, providing a possible mechanism for reduced nitric oxide (NO) production. Given that cardiovascular diseases are also associated with insulin resistance, and
Externí odkaz:
https://doaj.org/article/d7659ee073b14d18b554b7107c89fced