Zobrazeno 1 - 10
of 194
pro vyhledávání: '"David M Harlan"'
Autor:
Frederick R Roberts, Clinton Hupple, Elaine Norowski, Nicole C Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M Van Dessel, Agata Jurczyk, David M Harlan, Dale L Greiner, Rita Bortell, Chaoxing Yang
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178641 (2017)
Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients, imaging technology to visualize pancreas inflammatio
Externí odkaz:
https://doaj.org/article/dcdb65ec0f2844ffb919749025c32f45
Autor:
Peter D Burbelo, Evan E Lebovitz, Kathleen E Bren, Ahmad Bayat, Scott Paviol, Janet M Wenzlau, Katherine J Barriga, Marian Rewers, David M Harlan, Michael J Iadarola
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45216 (2012)
Type I diabetes (T1D) is an autoimmune disease characterized by destruction of insulin-producing β-cells in the pancreas. Although several islet cell autoantigens are known, the breadth and spectrum of autoantibody targets has not been fully explore
Externí odkaz:
https://doaj.org/article/973e5d6d665642e49e348cffd8520cbd
Autor:
H-C Jennifer Shen, Asha Adem, Kris Ylaya, Arianne Wilson, Mei He, Dominique Lorang, Stephen M Hewitt, Klaus Pechhold, David M Harlan, Irina A Lubensky, Laura S Schmidt, W Marston Linehan, Steven K Libutti
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e4897 (2009)
The von Hippel-Lindau (VHL) syndrome is a pleomorphic familial disease characterized by the development of highly vascularized tumors, such as hemangioblastomas of the central nervous system, pheochromocytomas, renal cell carcinomas, cysts and neuroe
Externí odkaz:
https://doaj.org/article/75dfb8e97c4249dcae4be14f918e358f
Autor:
Klaus Pechhold, Kerstin Koczwara, Xiaolong Zhu, Victor S Harrison, Greg Walker, Janet Lee, David M Harlan
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4827 (2009)
Type 1 diabetes mellitus is caused by immune-mediated destruction of pancreatic beta-cells leading to insulin deficiency, impaired intermediary metabolism, and elevated blood glucose concentrations. While at autoimmune diabetes onset a limited number
Externí odkaz:
https://doaj.org/article/c7eabff6ff664bdda64607cb2d384430
Autor:
Mark A Naftanel, David M Harlan
Publikováno v:
PLoS Medicine, Vol 1, Iss 3, p e58; quiz e75 (2004)
Externí odkaz:
https://doaj.org/article/6606b6b314d744a5855de53357cfb37a
Autor:
Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Publikováno v:
Diabetes. 72:261-274
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. In this article, we study temporal even
Publikováno v:
Diabetes Care. 45:23-27
Since diabetes was first described over 3,000 years ago, clinicians and scientists alike have sought ever improving treatments en route to a cure. As we approach the 100th anniversary of insulin’s first therapeutic use, this article will recount th
Autor:
Jennifer P. Wang, Manuel Garber, Dale L. Greiner, David M. Harlan, Christina E. Baer, Melanie I. Trombly, Emma Vanderleeden, Zhiru Guo, Sambra D. Redick, Basanthi Satish, Adediwura Arowosegbe, Alan G. Derr
Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study temporal events in pancr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf62201a02a2ebac32f4d90240eeab1
https://doi.org/10.2337/figshare.21494751
https://doi.org/10.2337/figshare.21494751
Autor:
Robert A. Hegele, Rita Bottino, Nripesh Prasad, Greg Poffenberger, John T. Walker, Marcela Brissova, Shristi Shrestha, Alvin C. Powers, Jenny Aurielle B. Babon, May Sanyoura, Andrea H. Ramirez, Conrad Reihsmann, Louis H. Philipson, Rachana Haliyur, Sally C. Kent, Sambra D. Redick, David M. Harlan, Radhika Aramandla
Publikováno v:
Journal of the Endocrine Society
Clinical and pathologic heterogeneity in type 1 diabetes is increasingly being recognized. Findings in the islets and pancreas of a 22-year-old male with 8 years of type 1 diabetes were discordant with expected results and clinical history (islet aut
Autor:
Neil Aronin, Mira Torres, Shamima Yeasmin, Uzma Mohammad Siddiqui, Sanaa Ayyoub, David M. Harlan, Sobia Raja
Publikováno v:
Endocrine Practice. 25:51-54
Objective: To analyze the frequency and nature of after-hours calls to endocrinology fellows and employ interventions to direct appropriate care to primary endocrinologists. Methods: The on-call fellows logged calls that came to them during the after