Zobrazeno 1 - 10
of 294
pro vyhledávání: '"David M Gilbert"'
Autor:
Pradeep Kumar, Omid Gholamalamdari, Yang Zhang, Liguo Zhang, Anastassiia Vertii, Tom van Schaik, Daan Peric-Hupkes, Takayo Sasaki, David M. Gilbert, Bas van Steensel, Jian Ma, Paul D. Kaufman, Andrew S. Belmont
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Genome differential positioning within interphase nuclei remains poorly explored. We extended and validated Tyramide Signal Amplification (TSA)-seq to map genomic regions near nucleoli and pericentric heterochromatin in four human cell lines
Externí odkaz:
https://doaj.org/article/cfb961e8f2924eb693d3f3d3481fa6c4
Autor:
Lorenzo Corazzi, Vivien S. Ionasz, Sergej Andrejev, Li-Chin Wang, Athanasios Vouzas, Marco Giaisi, Giulia Di Muzio, Boyu Ding, Anna J. M. Marx, Jonas Henkenjohann, Michael M. Allers, David M. Gilbert, Pei-Chi Wei
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells. Through high-resolution replication sequencing and a capture-ligation assay in mouse neural progenitor cells ex
Externí odkaz:
https://doaj.org/article/13d7755a88784e01a7e8da33478c4219
Autor:
Roberta L Hannibal, Edward B Chuong, Juan Carlos Rivera-Mulia, David M Gilbert, Anton Valouev, Julie C Baker
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004290 (2014)
Discovery of lineage-specific somatic copy number variation (CNV) in mammals has led to debate over whether CNVs are mutations that propagate disease or whether they are a normal, and even essential, aspect of cell biology. We show that 1,000 N polyp
Externí odkaz:
https://doaj.org/article/826687c148ed43859b54ab92899d3be0
Autor:
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. He
Externí odkaz:
https://doaj.org/article/7e8a67d729464111a78e5ef9b1dc0236
Autor:
Xianfang Wu, Jason M Robotham, Emily Lee, Stephen Dalton, Norman M Kneteman, David M Gilbert, Hengli Tang
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002617 (2012)
Primary human hepatocytes isolated from patient biopsies represent the most physiologically relevant cell culture model for hepatitis C virus (HCV) infection, but these primary cells are not readily accessible, display individual variability, and are
Externí odkaz:
https://doaj.org/article/5096e176640c4cd0b2e47c453f9eda57
Autor:
Tyrone Ryba, Ichiro Hiratani, Takayo Sasaki, Dana Battaglia, Michael Kulik, Jinfeng Zhang, Stephen Dalton, David M Gilbert
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002225 (2011)
Many types of epigenetic profiling have been used to classify stem cells, stages of cellular differentiation, and cancer subtypes. Existing methods focus on local chromatin features such as DNA methylation and histone modifications that require exten
Externí odkaz:
https://doaj.org/article/8c6609fd5c9146c893690faa6132d5a5
Autor:
Benjamin D Pope, Koji Tsumagari, Dana Battaglia, Tyrone Ryba, Ichiro Hiratani, Melanie Ehrlich, David M Gilbert
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27413 (2011)
Facioscapulohumeral muscular dystrophy (FSHD) is linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35.2 from 11-100 copies to 1-10 copies. The extent to which D4Z4 contraction at 4q35.2 affects overall 4q35.2 chromatin organizati
Externí odkaz:
https://doaj.org/article/112cd4fec6794d7697e5f8184e86edcb
Autor:
Ichiro Hiratani, Tyrone Ryba, Mari Itoh, Tomoki Yokochi, Michaela Schwaiger, Chia-Wei Chang, Yung Lyou, Tim M Townes, Dirk Schübeler, David M Gilbert
Publikováno v:
PLoS Biology, Vol 6, Iss 10, p e245 (2008)
DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these "replicon clusters" coalesce as subchro
Externí odkaz:
https://doaj.org/article/a5c1b235c4bc4d288b512d93863f6838
Autor:
Meng Zhang, Mary Elisabeth Ehmann, Srija Matukumalli, Aashutosh Girish Boob, David M. Gilbert, Huimin Zhao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chromatin boundary elements contribute to the partitioning of mammalian genomes into topological domains to regulate gene expression. Certain boundary elements are adopted as DNA insulators for safe and stable transgene expression in mammali
Externí odkaz:
https://doaj.org/article/66d99c0653d14d1b81af7d501ac5c018
Autor:
Marek Gierlinski, José A. da Costa-Nunes, Emma J. Haagensen, Takayo Sasaki, J. Julian Blow, David M. Gilbert
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: It has been known for many years that in metazoan cells, replication origins are organised into clusters where origins within each cluster fire near-synchronously. Despite clusters being a fundamental organising principle of metazoan DNA
Externí odkaz:
https://doaj.org/article/a76eca10627e41d8ae9b98b575ed5cfc