Zobrazeno 1 - 10
of 71
pro vyhledávání: '"David M Gay"'
Autor:
John RP Knight, Nikola Vlahov, David M Gay, Rachel A Ridgway, William James Faller, Christopher Proud, Giovanna R Mallucci, Tobias von der Haar, Christopher Mark Smales, Anne E Willis, Owen J Sansom
Publikováno v:
eLife, Vol 10 (2021)
Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mo
Externí odkaz:
https://doaj.org/article/5e114ade83534b699bbf0aa3797d2093
Autor:
David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells
Externí odkaz:
https://doaj.org/article/c9f52c1c744446f184d2f16004401292
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
All supplemental figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee3a26e547749f005f869f86f6004e
https://doi.org/10.1158/2159-8290.22540555
https://doi.org/10.1158/2159-8290.22540555
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56670615fce027f717d8d9f47081b8
https://doi.org/10.1158/2159-8290.c.6549409
https://doi.org/10.1158/2159-8290.c.6549409
Autor:
Jennifer P. Morton, Brian C. Lewis, Owen J. Sansom, Simon T. Barry, David S. Klimstra, Brian J. Quattrochi, Michael N. Hall, Nabeel Bardeesy, T.R. Jeffry Evans, Duncan I. Jodrell, Aarthi Gopinathan, Yusuke Mizukami, Jun Yu, Wright Jacob, David M. Gay, Makoto Sano, Saadia A Karim, David R. Driscoll
Supplementary figure legends for Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae71e4eb773492b275fd42aa34c3175c
https://doi.org/10.1158/0008-5472.22412330
https://doi.org/10.1158/0008-5472.22412330
Autor:
Almut Schulze, Owen J. Sansom, Grace H. McGregor, David M. Gay, Mathias T. Rosenfeldt, Hecham Marouf, Charis Kalogirou, Madelon Paauwe, Susanne Walz, Carsten P. Ade, Beatrice Dankworth, Andrew D. Campbell, Werner Schmitz, Carina R. Maier, Irem Kaymak
This file includes extended experimental procedures including 1. Analysis of RNA-sequencing and Cancer Genome Atlas data 2. Generation of shRNA Cell Lines, 3. Automated cell counting, 4. Liquid chromatography and mass spectrometry, 5. BrdU staining o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d825d23bc231b7811b25ce1d89a26aa
https://doi.org/10.1158/0008-5472.22425040.v1
https://doi.org/10.1158/0008-5472.22425040.v1
Autor:
Almut Schulze, Owen J. Sansom, Grace H. McGregor, David M. Gay, Mathias T. Rosenfeldt, Hecham Marouf, Charis Kalogirou, Madelon Paauwe, Susanne Walz, Carsten P. Ade, Beatrice Dankworth, Andrew D. Campbell, Werner Schmitz, Carina R. Maier, Irem Kaymak
Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2af7ff76b801d0bbd7476b91e88f16
https://doi.org/10.1158/0008-5472.c.6511930.v1
https://doi.org/10.1158/0008-5472.c.6511930.v1
Autor:
Jennifer P. Morton, Brian C. Lewis, Owen J. Sansom, Simon T. Barry, David S. Klimstra, Brian J. Quattrochi, Michael N. Hall, Nabeel Bardeesy, T.R. Jeffry Evans, Duncan I. Jodrell, Aarthi Gopinathan, Yusuke Mizukami, Jun Yu, Wright Jacob, David M. Gay, Makoto Sano, Saadia A Karim, David R. Driscoll
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aab9b95bc38903803b1f9810014169a
https://doi.org/10.1158/0008-5472.22412324.v1
https://doi.org/10.1158/0008-5472.22412324.v1
Autor:
Jennifer P. Morton, Brian C. Lewis, Owen J. Sansom, Simon T. Barry, David S. Klimstra, Brian J. Quattrochi, Michael N. Hall, Nabeel Bardeesy, T.R. Jeffry Evans, Duncan I. Jodrell, Aarthi Gopinathan, Yusuke Mizukami, Jun Yu, Wright Jacob, David M. Gay, Makoto Sano, Saadia A Karim, David R. Driscoll
mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors in pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cfe6c18f0c3605aec4a9950438b2a1
https://doi.org/10.1158/0008-5472.c.6508418
https://doi.org/10.1158/0008-5472.c.6508418
Autor:
Johan Vande Voorde, Arafath K. Najumudeen, Rory T. Steven, Chelsea J. Nikula, Alex Dexter, Lucas B. Zeiger, Efstathios A. Elia, Ammar Nasif, Ariadna Gonzalez-Fernandez, Teresa Murta, Michael Gillespie, Catriona A. Ford, Tamsin R.M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Kathryn Gilroy, David M. Gay, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Yuchen Xiang, Engy Shokry, William Clark, Vivian S.W. Li, Simon T. Barry, Richard J.A. Goodwin, Zoltan Takats, Oliver D.K. Maddocks, David Sumpton, Mariia O. Yuneva, Andrew D. Campbell, Josephine Bunch, Owen J. Sansom
With colorectal cancer (CRC) being the second most common cause of cancer-related deaths worldwide1, there is an urgent need for better diagnostic tools and new, more targeted therapies. Here we used genetically engineered mouse models (GEMMs), and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d49a1f23b41d8dcc99c9cad29a72865
https://doi.org/10.1101/2023.03.12.531945
https://doi.org/10.1101/2023.03.12.531945