Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David M Flavell"'
Autor:
Yalda Jamshidi, Hugh E. Montgomery, Hans-Werner Hense, Saul G. Myerson, Ines Pineda Torra, Bart Staels, Michael J. World, Angela Doering, Jeanette Erdmann, Christian Hengstenberg, Steve E. Humphries, Heribert Schunkert, David M. Flavell
Publikováno v:
Circulation 105, 950-955 (2002)
Background — Left ventricular hypertrophy (LVH) occurs as an adaptive response to a physiological (such as exercise) or pathological (valvular disease, hypertension, or obesity) increase in cardiac work. The molecular mechanisms regulating the LVH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f135190e16ba40b85a0ee9fe7d3fa5
https://ora.ox.ac.uk/objects/uuid:1088af7a-9506-4aad-b2d5-96d561542ba1
https://ora.ox.ac.uk/objects/uuid:1088af7a-9506-4aad-b2d5-96d561542ba1
Autor:
Lucie H. Clapp, Andrew Tinker, David M. Flavell, Bart Staels, Emilia Falcetti, Sheila G. Haworth
Publikováno v:
Biochemical and Biophysical Research Communications
Stable prostacyclin analogues can signal through cell surface IP receptors or by ligand binding to nuclear peroxisome proliferator-activated receptors (PPARs). So far these agents have been reported to activate PPARalpha and PPARdelta but not PPARgam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2472693b6bf431215c0da6f8f211c4f
https://doi.org/10.1016/j.bbrc.2007.06.135
https://doi.org/10.1016/j.bbrc.2007.06.135
Autor:
Alistair S. Hall, Philippa J. Talmud, Steve E. Humphries, Hugh Montgomery, Anthony J. Balmforth, Jackie A. Cooper, Khaled Alfakih, David M. Flavell, Mohan U. Sivananthan
Publikováno v:
Clinical Science. 112:617-624
LVH [LV (left ventricular) hypertrophy] is an independent risk factor for CHD (coronary heart disease). During LVH, the preferred cardiac energy substrate switches from FAs (fatty acids) to glucose. LPL (lipoprotein lipase) is the key enzyme in triac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7a21e76e2dcec3ffc3c3782b9e3e99
https://doi.org/10.1042/cs20060344
https://doi.org/10.1042/cs20060344
Autor:
Steven J. Hurel, Jay Acharya, Hugh M Mather, Emma Hawe, Jeffrey W. Stephens, Helen Ireland, David M. Flavell, Steve E. Humphries
Publikováno v:
Diabetes. 54:582-586
Dysregulation of fatty acid metabolism is important in the pathogenesis of type 2 diabetes. Peroxisome proliferator-activated receptor (PPAR)α is a master regulator of fatty acid catabolism, and PPARα activators delay the onset of type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8f3e94dc63013d6194bfc04778a0ce
https://doi.org/10.2337/diabetes.54.2.582
https://doi.org/10.2337/diabetes.54.2.582
Autor:
Christelle Foucher, Stephanie Rattier, David M. Flavell, John J.P. Kastelein, Jean-Claude Ansquer, Philippa J. Talmud, Steve E. Humphries, Simon N. Pimstone, George Steiner, Amir F. Ayyobi, Jiri Frohlich
Publikováno v:
Pharmacogenetics, 14(12), 823-829. Lippincott Williams and Wilkins
Objective The association between polymorphisms in candidate genes related to lipoprotein metabolism and the reduction in plasma triglyceride (TG) in response to fenofibrate treatment was evaluated in subjects with type 2 diabetes treated with micron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc0e253ca751a1a9b87324bb37dc713
https://doi.org/10.1097/00008571-200412000-00005
https://doi.org/10.1097/00008571-200412000-00005
Autor:
Dawn M. Waterworth, P.J. Talmud, David M. Flavell, Jian'an Luan, Nicholas J. Wareham, Christopher D. Byrne, S.E. Humphries
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1637(3):200-206
Variation in the insulin responsive element (IRE) of the APOC3 promoter has been shown to be associated with insulin and glucose concentrations after an oral glucose tolerance test (OGTT) in young healthy men. We evaluated two variants in the IRE (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36c2832ecb53d09b126219864658d74
Autor:
Mikko Syvänne, M. Heikki Frick, Amos Pasternack, Sylvia Nagl, Marja-Riitta Taskinen, George Steiner, Y. Antero Kesäniemi, Markku S. Nieminen, Richard L. Jackson, S Martin, David M. Flavell, Philippa J. Talmud, Steve E. Humphries, David B. Whitehouse
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:644-649
Objective— α 1 -Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials. Methods and Results— We examined the ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab05a541b5a39738648b72bb785d58e
https://doi.org/10.1161/01.atv.0000065196.61663.8d
https://doi.org/10.1161/01.atv.0000065196.61663.8d
Autor:
Amos Pasternack, Mikko Syvänne, Philippa J. Talmud, Steve E. Humphries, George J. Miller, Marja-Riitta Taskinen, Yalda Jamshidi, Inés Pineda Torra, Markku S. Nieminen, M. Heikki Frick, Y. Antero Kesäniemi, David M. Flavell, Emma Hawe, Bart Staels
Publikováno v:
Circulation. 105:1440-1445
Background — Peroxisome proliferator-activated receptor α (PPARα) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD). Methods and Result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922a4f6c3b243457bbc7306eebb660ec
https://doi.org/10.1161/01.cir.0000012145.80593.25
https://doi.org/10.1161/01.cir.0000012145.80593.25
Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene
Autor:
Andrew Michael Hitchin Ackrill, Carl D. Laxton, David M. Flavell, Graham Foster, Ian M. Kerr, George R. Stark
Publikováno v:
Nucleic Acids Research. 19:4387-4393
Expression of the E1A oncogene of adenovirus type 5 inhibits the response of interferon (IFN)-inducible constructs to Type I (alpha,beta) and II (gamma) IFNs in transient transfection assays. In human cell lines stably expressing E1A mRNA and protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06b5aab189f1ae2e3af143f1ff67de1
https://doi.org/10.1093/nar/19.16.4387
https://doi.org/10.1093/nar/19.16.4387
Autor:
Olga Vinogradova, Aleksei I Netreba, Anastasia B Vdovina, Ekaterina V. Lyubaeva, Irina A. Mozhayskaya, Pavel P. Tarakin, Ildus I. Ahmetov, David M. Flavell, Daniil V. Popov, Hugh Montgomery, Boris Shenkman, Irina V. Astratenkova, V. A. Rogozkin, Antonina I Komkova
Publikováno v:
European journal of applied physiology. 97(1)
Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARalpha intron 7 G/C polymorphism was associated with left ventricular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4bbffeb6f6ef471846e775b75902d4
https://pubmed.ncbi.nlm.nih.gov/16506057
https://pubmed.ncbi.nlm.nih.gov/16506057