Zobrazeno 1 - 10
of 663
pro vyhledávání: '"David M Evans"'
Autor:
Sindre Lee-Ødegård, Marit Hjorth, Thomas Olsen, Gunn-Helen Moen, Emily Daubney, David M Evans, Andrea L Hevener, Aldons J Lusis, Mingqi Zhou, Marcus M Seldin, Hooman Allayee, James Hilser, Jonas Krag Viken, Hanne Gulseth, Frode Norheim, Christian A Drevon, Kåre Inge Birkeland
Publikováno v:
eLife, Vol 13 (2024)
Background: Physical activity has been associated with preventing the development of type 2 diabetes and atherosclerotic cardiovascular disease. However, our understanding of the precise molecular mechanisms underlying these effects remains incomplet
Externí odkaz:
https://doaj.org/article/d8371b2a65a34ab0b877c43460d1a3c0
Publikováno v:
eLife, Vol 11 (2022)
Maternal genetic effects can be defined as the effect of a mother’s genotype on the phenotype of her offspring, independent of the offspring’s genotype. Maternal genetic effects can act via the intrauterine environment during pregnancy and/or via
Externí odkaz:
https://doaj.org/article/b55bb956ab9f46c9a84b0721e52e7d15
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010247 (2022)
Estimating effects of parental and sibling genotypes (indirect genetic effects) can provide insight into how the family environment influences phenotypic variation. There is growing molecular genetic evidence for effects of parental phenotypes on the
Externí odkaz:
https://doaj.org/article/622438873255431897301338d164e1bb
Autor:
Sarah A Gagliano Taliun, David M Evans
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009238 (2021)
Externí odkaz:
https://doaj.org/article/6d8707b02d0144bcaab9da3e823dae03
Autor:
Liang-Dar Hwang, Justin D Tubbs, Justin Luong, Mischa Lundberg, Gunn-Helen Moen, Geng Wang, Nicole M Warrington, Pak C Sham, Gabriel Cuellar-Partida, David M Evans
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009154 (2020)
Indirect parental genetic effects may be defined as the influence of parental genotypes on offspring phenotypes over and above that which results from the transmission of genes from parents to their children. However, given the relative paucity of la
Externí odkaz:
https://doaj.org/article/15b5ae747f874cecaf419ee44a6267a4
Autor:
Vincenzo Forgetta, Julyan Keller-Baruch, Marie Forest, Audrey Durand, Sahir Bhatnagar, John P Kemp, Maria Nethander, Daniel Evans, John A Morris, Douglas P Kiel, Fernando Rivadeneira, Helena Johansson, Nicholas C Harvey, Dan Mellström, Magnus Karlsson, Cyrus Cooper, David M Evans, Robert Clarke, John A Kanis, Eric Orwoll, Eugene V McCloskey, Claes Ohlsson, Joelle Pineau, William D Leslie, Celia M T Greenwood, J Brent Richards
Publikováno v:
PLoS Medicine, Vol 17, Iss 7, p e1003152 (2020)
BackgroundSince screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low geneti
Externí odkaz:
https://doaj.org/article/8be8dd60af7343b8a9aa0f6e09d1e428
Autor:
Gibran Hemani, Jie Zheng, Benjamin Elsworth, Kaitlin H Wade, Valeriia Haberland, Denis Baird, Charles Laurin, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Y Tan, James Yarmolinsky, Hashem A Shihab, Nicholas J Timpson, David M Evans, Caroline Relton, Richard M Martin, George Davey Smith, Tom R Gaunt, Philip C Haycock
Publikováno v:
eLife, Vol 7 (2018)
Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR method
Externí odkaz:
https://doaj.org/article/4389d253328149f8aa2d95abe6405f5b
Autor:
Deborah Lawlor, Rebecca Richmond, Nicole Warrington, George McMahon, George Davey Smith, Jack Bowden, David M Evans
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Mendelian randomization (MR), the use of genetic variants as instrumental variables (IVs) to test causal effects, is increasingly used in aetiological epidemiology. Few of the methodological developments in MR have considered the specific situation o
Externí odkaz:
https://doaj.org/article/ae9de2bf021549788e2a88e3dcca406b
Autor:
Cosetta Minelli, Charlotte H Dean, Matthew Hind, Alexessander Couto Alves, André F S Amaral, Valerie Siroux, Ville Huikari, María Soler Artigas, David M Evans, Daan W Loth, Yohan Bossé, Dirkje S Postma, Don Sin, John Thompson, Florence Demenais, John Henderson, SpiroMeta consortium, CHARGE consortium, Emmanuelle Bouzigon, Deborah Jarvis, Marjo-Riitta Järvelin, Peter Burney
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147388 (2016)
BACKGROUND:Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental expos
Externí odkaz:
https://doaj.org/article/6f5deea1163f486ebaf77ae1bbde862a
Autor:
Rebecca Gilbert, Richard M Martin, David M Evans, Kate Tilling, George Davey Smith, John P Kemp, J Athene Lane, Freddie C Hamdy, David E Neal, Jenny L Donovan, Chris Metcalfe
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0136735 (2015)
INTRODUCTION:Prostate-specific antigen (PSA) testing is a widely accepted screening method for prostate cancer, but with low specificity at thresholds giving good sensitivity. Previous research identified four single nucleotide polymorphisms (SNPs) p
Externí odkaz:
https://doaj.org/article/a832a8046efc4f98a30eac5419da371b