Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing

Autor: Emily McCarty, Justin Yu, Van K. Ninh, David M. Calcagno, Jodi Lee, Kevin R. King

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThe type I interferon (IFN) response is an innate immune program that mediates anti-viral, anti-cancer, auto-immune, auto-inflammatory, and sterile injury responses. Bone marrow derived macrophages (BMDMs) are commonly used to model macro

Externí odkaz: https://doaj.org/article/bb9bb582e2054d16b45af563c971ac39

Neutrophils incite and macrophages avert electrical storm after myocardial infarction

Autor: Jana, Grune, Andrew J M, Lewis, Masahiro, Yamazoe, Maarten, Hulsmans, David, Rohde, Ling, Xiao, Shuang, Zhang, Christiane, Ott, David M, Calcagno, Yirong, Zhou, Kerstin, Timm, Mayooran, Shanmuganathan, Fadi E, Pulous, Maximilian J, Schloss, Brody H, Foy, Diane, Capen, Claudio, Vinegoni, Gregory R, Wojtkiewicz, Yoshiko, Iwamoto, Tilman, Grune, Dennis, Brown, John, Higgins, Vanessa M, Ferreira, Neil, Herring, Keith M, Channon, Stefan, Neubauer, David E, Sosnovik, David J, Milan, Filip K, Swirski, Kevin R, King, Aaron D, Aguirre, Patrick T, Ellinor, Matthias, Nahrendorf

Publikováno v: Nature Cardiovascular Research. 1:649-664

Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukocyte changes. In this study, we optimized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aff3f247a8fea0a3ce6204034a6ea9
https://doi.org/10.1038/s44161-022-00094-w

NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH

Autor: David M. Calcagno, Angela Chu, Susanne Gaul, Nika Taghdiri, Avinash Toomu, Aleksandra Leszczynska, Benedikt Kaufmann, Bettina Papouchado, Alexander Wree, Lukas Geisler, Hal M. Hoffman, Ariel E. Feldstein, Kevin R. King

Publikováno v: Hepatology (Baltimore, Md.)REFERENCES. 76(3)

The NOD-like receptor protein 3 (NLRP3) inflammasome is a central contributor to human acute and chronic liver disease, yet the molecular and cellular mechanisms by which its activation precipitates injury remain incompletely understood. Here, we pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b8fa9f3d806c719a873c5dedad6725
https://pubmed.ncbi.nlm.nih.gov/34997987

SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification

Autor: Aaron D. Aguirre, Van Kim Ninh, Zhenxing Fu, Claire Zhang, Joan Heller Brown, Kevin R. King, David M Calcagno, Shigeki Miyamoto, Avinash Toomu, Kenneth Huang

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)

Background Neutrophils are thought to be short‐lived first responders to tissue injuries such as myocardial infarction (MI), but little is known about their diversification or dynamics. Methods and Results We permanently ligated the left anterior d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d99f273805f977a57f0998aa087441
https://pubmed.ncbi.nlm.nih.gov/33525909

Abstract MP153: TET2 Regulates Type I Interferon Signaling in the Hematopoietic Response to Myocardial Infarction

Autor: David M Calcagno, Avinash Toomu, Kevin R. King, Zhenxing Fu, Claire Zhang, Kenneth Huang

Publikováno v: Circulation Research. 127

Myocardial infarction (MI) elicits a rapid and vigorous reaction from the bone marrow hematopoietic compartment, inducing a massive efflux of myeloid first responders into the bloodstream. These cells traffic to the infarct, where they mediate cardia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3593f11bc2b5d3925222b51faee56bc3
https://doi.org/10.1161/res.127.suppl_1.mp153