Zobrazeno 1 - 10
of 55
pro vyhledávání: '"David M, Stresser"'
Publikováno v:
Drug Metabolism Reviews. :1-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398c1c3857c492747f9dd995870bd245
https://doi.org/10.1080/03602532.2023.2195133
https://doi.org/10.1080/03602532.2023.2195133
Publikováno v:
Drug Metabolism and Disposition. 50:105-113
Screening for cytochrome P450 (CYP) induction potential is routine in drug development. Induction results in a net increase in CYP protein and is assessed typically by measuring indirect endpoints, i.e., enzyme activity and mRNA in vitro. Recent meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23edfded86edd318df26cfee4cc64446
https://doi.org/10.1124/dmd.121.000638
https://doi.org/10.1124/dmd.121.000638
Autor:
Rick Adler, Famke Aeffner, Laura E. Armstrong, Dmitri Artemov, Adam D. Aulbach, Bindu M. Bennet, Eric A. Blomme, Brad Bolon, Christopher J. Bowman, Molly Boyle, Alys Bradley, Dino Bradley, Danielle Brown, Pierre R. Bushel, Ellen Cannady, Mark F. Cesta, Curtis Chan, Jennifer A. Chilton, Peter J.M. Clements, Torrie A. Crabbs, Myrtle A. Davis, Sandy Eldridge, Daniela Ennulat, Jeffrey Everitt, Isabel Figueroa, James D. Fikes, Thomas Forest, Catherine A. Foss, John R. Foster, Kathleen Gabrielson, Shayne C. Gad, Kapil Gadkar, Jinping Gan, David Garcia-Tapia, Frank J. Geoly, Wendy G. Halpern, Jerry F. Hardisty, Wanda M. Haschek, Kathleen Marie Heinz-Taheny, Kristi Helke, Lauren E. Himmel, Mark J. Hoenerhoff, Jennifer L. Ingram–Ross, Armando R. Irizarry Rovira, Evan B. Janovitz, Kishore Katyayan, Charlotte M. Keenan, Angela King-Herbert, Steven T. Laing, Lois D. Lehman-McKeeman, Na Li, Calvert Louden, Claire Lyons, Kevin McDorman, Elizabeth McInnes, Lyn Miller Wancket, Sheroy Minocherhomji, Sébastien Monette, James Morrison, Vasanthi Mowat, Sydney Mukaratirwa, Keith Nelson, Arun R. Pandiri, Tracey Papenfuss, Nita Patel, Daniel J. Patrick, Shari A. Price, Deepa B. Rao, James T. Raymond, Jennifer Rojko, Colin G. Rousseaux, Sara F. Santagostino, Aaron Sargeant, Christina Satterwhite, A. Eric Schultze, Vanessa Schumacher, Cheryl Scudamore, Keith R. Shockley, Bhanu P. Singh, David M. Stresser, Polina Sysa-Shah, Debra A. Tokarz, Terry Van Vleet, Matthew A. Wallig, Jin Wang, Cynthia J. Willson, Kristin Lewis Wilson, Christopher T. Winkelmann, Jeffrey C. Wolf, Charles Wood, Daniela Bumbaca Yadav, Mark Zarella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3831ed61c4599a4d47034bfb7e19d99
https://doi.org/10.1016/b978-0-12-821044-4.01002-5
https://doi.org/10.1016/b978-0-12-821044-4.01002-5
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
In this chapter, we illustrate the criticality of proper fitting of enzyme kinetic data. Simple techniques are provided to arrive at meaningful kinetic parameters, illustrated using an example, nonmonotonic data set. In the initial analysis of this d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78cb190cb9ae2c1067889dbeb75d8bff
https://pubmed.ncbi.nlm.nih.gov/34272710
https://pubmed.ncbi.nlm.nih.gov/34272710
Autor:
Thomas K. Baker, Radhakrishna Sura, Josesph Cichocki, David M Stresser, Paul Levesque, Diane Ramsden, Myrtle Davis, Gary A. Gintant, Christopher M. Hale, Jonathan Maher, Amy Pointon, Kyle L. Kolaja
Publikováno v:
Lab on a chip. 21(3)
The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. Progress has been made in independently developing simple in vitro models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58ac64ab0b3f6fceab193d783353528
https://pubmed.ncbi.nlm.nih.gov/33471007
https://pubmed.ncbi.nlm.nih.gov/33471007
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
In this chapter, we illustrate the criticality of proper fitting of enzyme kinetic data. Simple techniques are provided to arrive at meaningful kinetic parameters, illustrated using an example, nonmonotonic data set. In the initial analysis of this d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d88d694b36a403942a69b1de3621e3
https://doi.org/10.1007/978-1-0716-1554-6_22
https://doi.org/10.1007/978-1-0716-1554-6_22
Autor:
David M. Stresser
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::786de4613b4304ef526183b0e900379f
https://doi.org/10.1007/978-1-0716-1542-3_4
https://doi.org/10.1007/978-1-0716-1542-3_4
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(3)
Induction of cytochrome P450 can cause drug-drug interactions and efficacy failure. Induction risk in liver and gut is typically inferred from experiments with plated hepatocytes. Organoids are physiologically relevant, multicellular structures origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952fa54ae58381279d3c4b86a2749644
https://pubmed.ncbi.nlm.nih.gov/33355212
https://pubmed.ncbi.nlm.nih.gov/33355212
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(7)
Despite the availability of liquid chromatography (LC)-mass spectrometry (MS) methods for quantifying cytochrome P450 (P450) proteins, incorporation of P450 protein quantification into induction study workflows has not been widely adopted. To more re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1284a7c7685b80df5332b6e2525b16fe
https://pubmed.ncbi.nlm.nih.gov/32350061
https://pubmed.ncbi.nlm.nih.gov/32350061