Zobrazeno 1 - 10
of 324
pro vyhledávání: '"David M, Roth"'
Autor:
Elena L. Kopp, Daniel N. Deussen, Raphael Cuomo, Reinhard Lorenz, David M. Roth, Sushil K. Mahata, Hemal H. Patel
Publikováno v:
Cells, Vol 12, Iss 24, p 2786 (2023)
Type 2 diabetes (T2D) has a complex pathophysiology which makes modeling the disease difficult. We aimed to develop a novel model for simulating T2D in vitro, including hyperglycemia, hyperlipidemia, and variably elevated insulin levels targeting mus
Externí odkaz:
https://doaj.org/article/e19c7bd6e49641b7a54de4fd681033b0
Autor:
Young Song, Joseph Leem, Mehul Dhanani, M Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O Harrington, H Kirk Hammond, David M Roth, Hemal H Patel
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281550 (2023)
Role of blood-based factors in development and progression of heart failure (HF) is poorly characterized. Blood contains factors released during pathophysiological states that may impact cellular function and provide mechanistic insights to HF manage
Externí odkaz:
https://doaj.org/article/72a857b7ce3f4c92a22888e4870cf155
Autor:
Shanshan Wang, Joseph S. Leem, Sonia Podvin, Vivian Hook, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Phuong Nguyen, Alexander Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, Hemal H. Patel, Piyush M. Patel, Brian P. Head
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 434-450 (2021)
Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PS
Externí odkaz:
https://doaj.org/article/9a008a9a994349fab892e7d7e193a9c9
Autor:
Shanshan Wang, Zheng Zhang, Angels Almenar-Queralt, Joseph Leem, Celine DerMardirossian, David M. Roth, Piyush M. Patel, Hemal H. Patel, Brian P. Head
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome,
Externí odkaz:
https://doaj.org/article/2517b4412d6a40e18f38930f97f54293
Autor:
Chun Hang Tang, Beulah Ji, Ana Malvar, Y K Onno Teng, Brad H. Rovin, Jennifer A Gilbride, Gabriel Contreras, Richard Furie, David M. Roth, Xueqing Yu, Damon Bass, Yulia Green, Tania Gonzalez-Rivera
Publikováno v:
Kidney International, 101(2), 403-413. ELSEVIER SCIENCE INC
We performed a post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN), a Phase 3, multinational, double-blind, 104-week trial, in which 448 patients with lupus nephritis were randomized to receive intravenous belimumab 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9139836592dd4624cd96a6d2829ad0e
https://doi.org/10.1016/j.kint.2021.08.027
https://doi.org/10.1016/j.kint.2021.08.027
Autor:
David M. Roth, Susan W Burriss, Michelle Miller, J. Groark, Kathleen Maksimowicz-McKinnon, Luiz Sergio Guedes Barbosa, Amy Pierce, Ellen M. Ginzler, Mittermayer Barreto Santiago, Beulah Ji, Jennifer A Gilbride, Saira Z Sheikh, Richard Furie, Amit Saxena, Jim C. Oates, Damon Bass, David D'Cruz
Publikováno v:
Arthritis & Rheumatology. 74:112-123
Objective Enrollment of patients of Black African ancestry with systemic lupus erythematosus (SLE) in Phase 2 and 3 belimumab trials was not reflective of the racial distribution observed in the lupus population. This study assessed efficacy and safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c9fae2800aa2420a308a9eff97554a
https://doi.org/10.1002/art.41900
https://doi.org/10.1002/art.41900
Autor:
Bernie Rubin, Kerry Gairy, Tania Gonzalez-Rivera, David M. Roth, Roger A. Levy, Susan W Burriss, N.L. Fox, Munther Khamashta, André van Maurik, Angela Jones-Leone
Publikováno v:
Lupus
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease affecting both adults and children. Belimumab is the only biologic approved for SLE, and the first in a class of drugs known as B-lymphocyte stimulator-specific inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35583ea64309e0f1689c5edf3cb8290e
https://doi.org/10.1177/09612033211028653
https://doi.org/10.1177/09612033211028653
Autor:
Isabella C. Kelly, Mehul Dhanani, John Q. Trojanowski, Kimberly Zhou, Sonia Podvin, Steve L. Wagner, Atsushi Miyanohara, Shanshan Wang, Piyush M. Patel, Tong Zhang, Vivian Hook, Alexander M. Kleschevnikov, Phuong Nguyen, Joseph Leem, Natalia Kleschevnikov, Brian P. Head, David M. Roth, Hemal H. Patel, Paul Savchenko
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 434-450 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 434-450 (2021)
Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecde459cbf8b7e4efc353012ef591897
https://doi.org/10.1016/j.omtm.2021.03.021
https://doi.org/10.1016/j.omtm.2021.03.021
Autor:
Yasuhiro Ichikawa, Alice E Zemljic-Harpf, Zheng Zhang, M Dan McKirnan, Ana Maria Manso, Robert S Ross, H Kirk Hammond, Hemal H Patel, David M Roth
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177660 (2017)
Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signali
Externí odkaz:
https://doaj.org/article/785157a1d7cc406e9698745e0dd63ed3
Autor:
Raj Punwaney, Sandra V. Navarra, Amy Pierce, Saira Z Sheikh, Ricardo Acayaba de Toledo, Josep Ordi Ros, Roger A. Levy, Ignacio García-De La Torre, Jorge Alfonso Ross Terres, James Cheng-Chung Wei, David M. Roth, Morton Scheinberg, Beulah Ji, Mercedes A. García, Julia Harris, Damon Bass, Alireza Nami, Tamara Mucenic, D. Tegzova, Kevin S. Thorneloe, Kathleen Maksimowicz-McKinnon, Mauricio R Abello Banfi, William Stohl, Carlos Abud-Mendoza
Publikováno v:
The Lancet Rheumatology. 3:e122-e130
Summary Background Belimumab is approved for the treatment of active systemic lupus erythematosus (SLE). Although clinical trials showed a favourable benefit–risk profile, numerical differences in the incidence of mortality and adverse events of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989c7c15b3fcc1f5355d6097d313e0ff
https://doi.org/10.1016/s2665-9913(20)30355-6
https://doi.org/10.1016/s2665-9913(20)30355-6