Zobrazeno 1 - 10
of 145
pro vyhledávání: '"David M, Rand"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Many common diseases exhibit uncontrolled mTOR signaling, prompting considerable interest in the therapeutic potential of mTOR inhibitors, such as rapamycin, to treat a range of conditions, including cancer, aging-related patholog
Externí odkaz:
https://doaj.org/article/ae444262148545cebdd039dcb7dc31ef
Autor:
John C. Santiago, Joan M. Boylan, Faye A. Lemieux, Philip A. Gruppuso, Jennifer A. Sanders, David M. Rand
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background In addition to their well characterized role in cellular energy production, new evidence has revealed the involvement of mitochondria in diverse signaling pathways that regulate a broad array of cellular functions. The mitochondri
Externí odkaz:
https://doaj.org/article/64f354fa81d643da9c7e4dff588f3ae6
Publikováno v:
Animal Microbiome, Vol 2, Iss 1, Pp 1-16 (2020)
Abstract Background Natural populations inhabiting the rocky intertidal experience multiple ecological stressors and provide an opportunity to investigate how environmental differences influence microbiomes over small geographical scales. However, ve
Externí odkaz:
https://doaj.org/article/2ac0177a7bce4158a3ca74630f96c47c
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-23 (2019)
Abstract Background Mitochondria perform many key roles in their eukaryotic hosts, from integrating signaling pathways through to modulating whole organism phenotypes. The > 1 billion years of nuclear and mitochondrial gene co-evolution has necessita
Externí odkaz:
https://doaj.org/article/eecf42858479486c89c0d981498d0bdb
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 4, Pp 1175-1188 (2019)
Mitochondrial DNA (mtDNA) has been one of the most extensively studied molecules in ecological, evolutionary and clinical genetics. In its early application in evolutionary genetics, mtDNA was assumed to be a selectively neutral marker conferring neg
Externí odkaz:
https://doaj.org/article/3f72ff389da04527abd842fa695a81e1
Autor:
Adam N Spierer, Jim A Mossman, Samuel Pattillo Smith, Lorin Crawford, Sohini Ramachandran, David M Rand
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1008887 (2021)
The winged insects of the order Diptera are colloquially named for their most recognizable phenotype: flight. These insects rely on flight for a number of important life history traits, such as dispersal, foraging, and courtship. Despite the importan
Externí odkaz:
https://doaj.org/article/4295191819b24473bf872086bdb9c275
Autor:
Nicolas Pichaud, Roxanne Bérubé, Geneviève Côté, Claude Belzile, France Dufresne, Geneviève Morrow, Robert M. Tanguay, David M. Rand, Pierre U. Blier
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Mitochondrial and nuclear genomes have to coevolve to ensure the proper functioning of the different mitochondrial complexes that are assembled from peptides encoded by both genomes. Mismatch between these genomes is believed to be strongly selected
Externí odkaz:
https://doaj.org/article/b5e819ae689342ff913d2f54f925cab4
Autor:
Jamila H. Siamwala, Jim A. Mossman, Christoph Schorl, Diana Borgas, Pavlo Sakhatskyy, David M. Rand, Qing Lu, Sharon Rounds
Publikováno v:
Physiological Genomics.
Background Cigarette smoke exposure increases the risk of developing Acute Respiratory Distress Syndrome (ARDS) after a number of disparate insults 1-3. It is not known why some at risk individuals develop ARDS, while others do not. Based on our prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7100e4d88688f9e94686912d4766ef8
https://doi.org/10.1152/physiolgenomics.00152.2022
https://doi.org/10.1152/physiolgenomics.00152.2022
Autor:
Joaquin C. B. Nunez, Leann M. Biancani, Patrick A. Flight, Diane E. Nacci, David M. Rand, Douglas L. Crawford, Marjorie F. Oleksiak
Publikováno v:
Royal Society Open Science, Vol 5, Iss 5 (2018)
Populations of the non-migratory estuarine fish Fundulus heteroclitus inhabiting the heavily polluted New Bedford Harbour (NBH) estuary have shown inherited tolerance to local pollutants introduced to their habitats in the past 100 years. Here we exa
Externí odkaz:
https://doaj.org/article/7a967f3f290b40038c6288914c18be74
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 843-854 (2015)
Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes, which produce the majority of cellular energy, requires the coordinated expression and translation of both mit
Externí odkaz:
https://doaj.org/article/c8ec8dbd0a4c4165bbc306313da940f4