Anti-DEspR antibody treatment improves survival and reduces neurologic deficits in a hypertensive, spontaneous intracerebral hemorrhage (hsICH) rat model

Autor: Victoria L. M. Herrera, Christopher M. Gromisch, Julius L. Decano, Khristine Amber Pasion, Glaiza L. A. Tan, Ning Hua, Courtney E. Takahashi, David M. Greer, Nelson Ruiz-Opazo

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Progressive secondary brain injury—induced by dysregulated neuroinflammation in spontaneous intracerebral hemorrhage (sICH)—underlies high sICH-mortality and remains without FDA-approved pharmacotherapy. Clinical insight that hematoma-di

Externí odkaz: https://doaj.org/article/33396bd56af74fc98fcb9f472609131a

Do Neuroprognostic Studies Account for Self-Fulfilling Prophecy Bias in Their Methodology? The SPIN Protocol for a Systematic Review

Autor: Fernanda J. P. Teixeira, MD, Bakhtawar Ahmad, MBBS, Viktoriya Gibatova, MS, Pouya A. Ameli, MD, MS, Ivan da Silva, MD, PhD, Thiago Carneiro, MD, MPH, William Roth, MD, Jenna L. Ford, MD, Terry Kit Selfe, PhD, David M. Greer, MD, MA, Katharina M. Busl, MD, MS, Carolina B. Maciel, MD, MSCR

Publikováno v: Critical Care Explorations, Vol 5, Iss 7, p e0943 (2023)

Background:. Self-fulfilling prophecy bias occurs when a perceived prognosis leads to treatment decisions that inherently modify outcomes of a patient, and thus, overinflate the prediction performance of prognostic methods. The goal of this series of

Externí odkaz: https://doaj.org/article/10558d79d06e49d7a537732ed9d11bd4

'Rogue' [DEspR+CD11b+] neutrophil subset correlates with severity in spontaneous intracerebral hemorrhage

Autor: Victoria L. M. Herrera, Courtney E. Takahashi, Mai Q. Nguyen, Julie Z. Mosaddeghi, Ridiane Denis, David M. Greer, Nelson Ruiz-Opazo

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

ObjectiveCumulative clinical, cellular, and molecular evidence reinforces the role of neutrophils in secondary brain injury in spontaneous intracerebral hemorrhage (sICH). However, since generalized neutrophil inhibition is detrimental, identificatio

Externí odkaz: https://doaj.org/article/47537858567741b68273da9d1eb5323e

Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study

Autor: Pedro Kurtz, MD, Christian Storm, MD, Marcio Soares, MD, Fernando Bozza, MD, Carolina B. Maciel, MD, David M. Greer, MD, Leonardo S. L. Bastos, MSc, Ulisses Melo, MD, Bruno Mazza, MD, Marcelo S. Santino, MD, Roberto Seabra Lannes, MD, Ana Paula Pierre de Moraes, MD, Joel Tavares Passos, MD, Giulliana Martines Moralez, MD, Robson Correa Santos, MD, Maristela Medeiros Machado, MD, Saulo Fernandes Saturnino, MD, Ciro Leite Mendes, MD, Arthur Oswaldo Vianna, MD, Jorge Salluh, MD, on behalf of the ORCHESTRA Study Investigators, Maristela Medeiros Machado, Luciano Ferreira de Souza, Rubens Antônio Bento Ribeiro, Eduardo Cesar Guimarães Lessa, Clayton Barbieri de Carvalho, Tullio Xavier Leirias, Marcelo de Oliveira Maia, Edmilson Leal Bastos, Rebeca Martins da Silva Barros, Cintya M.V. Oliveira, Jose Aires A Neto, Eliana Bernadete Caser, Silvane Damasceno, Marcelo Rabahi Fouad, Marco Antônio Mendes Castilho, Durval Ferreira Fonseca Pedroso, Humberto Borges Barbosa, Ana Paula Pierre de Moraes, Ana Cláudia Pinho de Carvalho, Alexandre Guilherme Ribeiro de Carvalho, Akemy Carvalho do Rosário, Marcelo Ferreira Sousa, Marcia Maria Ferreira de Souza, Saulo Fernandes Saturnino, Ciro Leite Mendes, Paulo César Gottardo, Igor Mendonça do Nascimento, Mariza da Fonte Andrade Lima, Marçal Paiva, Carlos Eduardo Ferraz Freitas, Lanecley Gouveia Neves Fulco, Maurício Magalhães Cabral, Luciane Ishiy, Renato Fábio Alberto Della Santa Neto, Giulliana Martines Moralez, Flavio Callil, Claudio Eduardo Calife Chagas, Eliane Casanova, Antonio Carlos Babo Rodrigues, Bruno Vidal, Arthur O. A. Vianna, Patrícia Soares D’Alessandro, Robson Correa Santos, Ricardo Pessoa Martelo, Rodrigo Barros, Luisa Chuairi, Roberto Costa, Cristiane Belo, Giulia P. C. Lima, Cristiane Cariús, Eduardo Xavier, Claudia Lourenço de Almeida, Rafael Sibanto, Alessandra Longo, Joyce Roma, Juliana Gurgel da Silveira, Laura Brasil Herranz, Gustavo Vaz, Bruno Cartelo Branco, Leonardo Campioni, Alexandre Coscia, Walter Homena, Marcelo de Sousa Santino, Juan Carlos Verdeal, William Nascimento Viana e Lígia Sarmet Farah Cunha Rabello, Janaína Oliveira, Cecília Magno, Alex Gaspar, Guilherme Feres, Maria Teresa Saint-Martin, Eric Perecmanis, Jorge Eduardo da Silva Soares Pinto, Sergio Teixeira Sant’Anna Junior, Guilherme Brenande Alves Faria, Alcino Márcio Toledo de Medeiros, Márcia Adélia de Magalhães Menezes, Rosa Imaculada Stancato, Joyce Andrade, Alessandra Alves, Alexandre Vaz Scotti, Roberto Seabra Lannes, Sion Divan Filho, Andrea Ludovico, Marcos Knibel, Emir Oliveira, Pedro Azambuja, Aline Affonso, Joel Tavares Passos, Carlos Cesar Hortala Junior, Edmundo de Oliveira Tommasi, Patricia Frascari Litrento, Alexandra Gonçalves da Silva, Henrique Miller Balieiro, Fellipe de Freitas Pereira, Ulisses de Oliveira Melo, Edson Tristão, Kelsey Sampaio, Rogerio Silveira, Antonio Carlos, Felipe Mafort, Jose Hipólito, Valquíria Queiroz, Bruno Azevedo da Cruz, Karla Biancha Silva de Andrade, Thiago Lisboa, André P. Torelly, Daniella Birriel, Edison Moraes Rodrigues Filho, José Pettine, Moreno Calcagnotto dos Santos, Tiago Almeida Ramos, Fernando Bourscheit, Ana Flávia Gallas Leivas, Marcus Antonio Ferez, Edson Antonio Nicolini, Fernando Vinicius Cesar De Marco, Guilherme Paro de Toledo, Ulysses V. Andrade e Silva, Cristina Prata Amendola, Fernando Colombari, Thiago Domingos Corrêa, Eliézer Silva, José Mauro Vieira, Jr, Luciano Azevedo, Fernando Ramos, Silvia Regina Ramos, Lilian Mara Perroud Miilher, Flávio Geraldo Rezende de Freitas, Antônio Tonete Bafi, Eduardo Souza Pacheco, Dieter Eduardo Siefeld Araya, Ronaldo Escudeiro Borba, Moacyr Fogolin Junior, Pedro Ivo Buainain, Mariza Luciana Pregun, José Albani Carvalho, Jr, Mariza Silva Ramos Loesch, Kassia Pinho, Bruno Franco Mazza, Samantha Longhi de Almeida, Rosa Goldstein Alheira Rocha, Edson Romano, Fernando Zampieri, Carlos Eduardo Nassif Moreira, Bruno Adler Maccagnan Pinheiro Besen, Carlos Eduardo Brandão

Publikováno v: Critical Care Explorations, Vol 3, Iss 7, p e0479 (2021)

OBJECTIVES:. Data on cardiac arrest survivors from developing countries are scarce. This study investigated clinical characteristics associated with in-hospital mortality in resuscitated patients following cardiac arrest in Brazil. DESIGN:. Retrospec

Externí odkaz: https://doaj.org/article/f47d8e08af8746da8585f3a9c550e2aa

What does 'brainstem death' mean? A review of international protocols

Autor: W. E. Spears, Ariane Lewis, Azza Bakkar, Elana Kreiger-Benson, Andrew Kumpfbeck, Jordan Liebman, Gene Sung, Sylvia Torrance, Sam D. Shemie, David M. Greer

Publikováno v: Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 70:651-658

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::379b3b1d5140e8f9af7cea70200569a0
https://doi.org/10.1007/s12630-023-02428-z