Zobrazeno 1 - 10
of 232
pro vyhledávání: '"David Lyden"'
Autor:
JangKeun Kim, Braden T. Tierney, Eliah G. Overbey, Ezequiel Dantas, Matias Fuentealba, Jiwoon Park, S. Anand Narayanan, Fei Wu, Deena Najjar, Christopher R. Chin, Cem Meydan, Conor Loy, Begum Mathyk, Remi Klotz, Veronica Ortiz, Khiem Nguyen, Krista A. Ryon, Namita Damle, Nadia Houerbi, Laura I. Patras, Nathan Schanzer, Gwyneth A. Hutchinson, Jonathan Foox, Chandrima Bhattacharya, Matthew Mackay, Evan E. Afshin, Jeremy Wain Hirschberg, Ashley S. Kleinman, Julian C. Schmidt, Caleb M. Schmidt, Michael A. Schmidt, Afshin Beheshti, Irina Matei, David Lyden, Sean Mullane, Amran Asadi, Joan S. Lenz, Omary Mzava, Min Yu, Saravanan Ganesan, Iwijn De Vlaminck, Ari M. Melnick, Darko Barisic, Daniel A. Winer, Sara R. Zwart, Brian E. Crucian, Scott M. Smith, Jaime Mateus, David Furman, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found th
Externí odkaz:
https://doaj.org/article/cc2e3326e2ed4156ba8feba0fbc05ee1
Autor:
Eliah G. Overbey, Krista Ryon, JangKeun Kim, Braden T. Tierney, Remi Klotz, Veronica Ortiz, Sean Mullane, Julian C. Schmidt, Matthew MacKay, Namita Damle, Deena Najjar, Irina Matei, Laura Patras, J. Sebastian Garcia Medina, Ashley S. Kleinman, Jeremy Wain Hirschberg, Jacqueline Proszynski, S. Anand Narayanan, Caleb M. Schmidt, Evan E. Afshin, Lucinda Innes, Mateo Mejia Saldarriaga, Michael A. Schmidt, Richard D. Granstein, Bader Shirah, Min Yu, David Lyden, Jaime Mateus, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Fligh
Externí odkaz:
https://doaj.org/article/b22dea1eff964fe5b8f65b60bc282674
Autor:
Padma P. Nanaware, Zohaib N. Khan, Cristina C. Clement, Madhur Shetty, Ines Mota, Ethan S. Seltzer, Monika Dzieciatkowska, Fabia Gamboni, Angelo D’Alessandro, Charles Ng, Manabu Nagayama, Cheryl F. Lichti, Rajesh K. Soni, Jacob B. Geri, Irina Matei, David Lyden, Randy Longman, Theresa T. Lu, Xiaoxiao Wan, Emil R. Unanue, Lawrence J. Stern, Laura Santambrogio
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114311- (2024)
Summary: The lymphatic fluid is the conduit by which part of the tissue “omics” is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric afferent lymphatics, herein we invest
Externí odkaz:
https://doaj.org/article/957cfb99c70846f691804304c5c2963b
Autor:
Linda Bojmar, Han Sang Kim, Kei Sugiura, Søren Heissel, Serena Lucotti, Michele Cioffi, Kofi Ennu Johnson, Leona Cohen-Gould, Haiying Zhang, Henrik Molina, Irina R. Matei, David Lyden, Ayuko Hoshino
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102754- (2024)
Summary: Characterization of isolated extracellular vesicles and particles (EVPs) is crucial for determining functions and biomarker potential. Here, we present a protocol to analyze size, number, morphology, and EVP protein cargo and to validate EVP
Externí odkaz:
https://doaj.org/article/bd44e6608aab453fbb65260be70b9ae9
Autor:
Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Alba Fiorentino, Chandan Guha, Monica L. Guzman, Kevin Harrington, Fernanda G. Herrera, Jamie Honeychurch, Theodore Hong, Lorea Iturri, Elisabeth Jaffee, Sana D. Karam, Simon R.V. Knott, Constantinos Koumenis, David Lyden, Ariel E. Marciscano, Alan Melcher, Michele Mondini, Anna Mondino, Zachary S. Morris, Sean Pitroda, Sergio A. Quezada, Laura Santambrogio, Stephen Shiao, John Stagg, Irma Telarovic, Robert Timmerman, Marie-Catherine Vozenin, Ralph Weichselbaum, James Welsh, Anna Wilkins, Chris Xu, Roberta Zappasodi, Weiping Zou, Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch, Silvia C. Formenti
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTFocal radiation therapy (RT) has attracted considerable attention as a combinatorial partner for immunotherapy (IT), largely reflecting a well-defined, predictable safety profile and at least some potential for immunostimulation. However, onl
Externí odkaz:
https://doaj.org/article/420f3d04260044b482062ca48125b481
Autor:
Laurence Blavier, Rie Nakata, Paolo Neviani, Khounish Sharma, Hiroyuki Shimada, Aitor Benedicto, Irina Matei, David Lyden, Yves A. DeClerck
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 5, Pp n/a-n/a (2023)
Abstract The capture of tumour‐derived extracellular vesicles (TEVs) by cells in the tumour microenvironment (TME) contributes to metastasis and notably to the formation of the pre‐metastatic niche (PMN). However, due to the challenges associated
Externí odkaz:
https://doaj.org/article/6ec20ddebcdc41519688e2d3bb29de3a
Autor:
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E. Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R. Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A. Porco, Christine A. Iacobuzio-Donahue, Nikolaus Schultz, David A. Tuveson, David Lyden, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Cancer-associated fibroblasts are transcriptionally rewired by signals from the cancer cells, resulting in heterogeneous populations. Here the authors show that loss of BRCA function in pancreatic cancer cells leads to HSF1–dependent accumulation o
Externí odkaz:
https://doaj.org/article/ace9d26882394fbe81d1eae2056e5de9
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Mengying Hu, David Lyden, Wenbing Jin, Chunjun Guo, Noah Dephoure, Lewis C. Cantley, Ashley M. Laughney, John Blenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Methylmalonic acid (MMA) is increased in aging as well as produced by advanced tumors, and can drive pro-aggressive changes in these tumor cells. Here, the authors show that MMA can also act on fibroblasts in the tumor microenvironment, recruiting an
Externí odkaz:
https://doaj.org/article/f478066cc8a441dda1055be79d728377
Autor:
Antonio Strillacci, Pasquale Sansone, Vinagolu K. Rajasekhar, Mesruh Turkekul, Vitaly Boyko, Fanli Meng, Brian Houck-Loomis, David Brown, Michael F. Berger, Ronald C. Hendrickson, Qing Chang, Elisa de Stanchina, Fresia Pareja, Jorge S. Reis-Filho, Ramya Segu Rajappachetty, Isabella Del Priore, Bo Liu, Yanyan Cai, Alex Penson, Chiara Mastroleo, Marjan Berishaj, Francesca Borsetti, Enzo Spisni, David Lyden, Sarat Chandarlapaty, Jacqueline Bromberg
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is
Externí odkaz:
https://doaj.org/article/f78ea24d939745a8868b8fcd4d4bff37
Autor:
Jeesoo Choi, Ho Yeon Cho, Jeongseok Jeon, Kyung-A Kim, Yoon Dae Han, Joong Bae Ahn, Inbal Wortzel, David Lyden, Han Sang Kim
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundExtracellular vesicles secreted by tumor cells contain double-stranded DNA called extracellular vesicle DNA (evDNA). EvDNA is genomic DNA that reflects cancer driver mutations. However, the significance of evDNA analysis in the diagnosis an
Externí odkaz:
https://doaj.org/article/e0d5361c710047c7a8e695ce26f64768