Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David Lustig"'
Autor:
Kwan Leung, Ken Rehder, Xiaofen Li, Bob Jiang, Marie Nguyen, Timothy A. Marquart, Nancy Chu, Victoria Y. Maydanik, David Lustig, Kevin D. Shenk, Yuan Li, Elfatih Elzein, Reina Natero, Daniel Soohoo, Prabha Ibrahim, Jeff Zablocki, Suresh S. Kerwar, Dmitry Koltun, Jia Hao, Dewan Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:6017-6021
New inhibitors of palmitoyl-CoA oxidation are based on the introduction of nitrogen heterocycles in the ‘Western Portion’ of the molecule. SAR studies led to the discovery of CVT-4325 (shown), a potent FOXi (IC50 = 380 nM rat mitochondria) with f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80324da80b70144f2e62fa211bc8e33
https://doi.org/10.1016/j.bmcl.2004.09.077
https://doi.org/10.1016/j.bmcl.2004.09.077
Autor:
Irving Fong, Elfatih Elzein, Prabha Ibrahim, Lin Wu, Jeff Zablocki, Timothy A. Marquart, Yuzhi Wu, David Lustig, Dewan Zeng, Christopher Morrison, Tenning Maa, Bob Jiang, Kevin D. Shenk, Kwan Leung, Venkata Palle, Vaibhav Varkhedkar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3793-3797
Atrial fibrillation (AF) is the most commonly encountered sustained clinical arrhythmia with an estimated 2.3 million cases in the US (2001). A(1) adenosine receptor agonists can slow the electrical impulse propagation through the atrioventricular (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd5013dbbffd866cc6467c1064d1f04
https://doi.org/10.1016/j.bmcl.2004.04.096
https://doi.org/10.1016/j.bmcl.2004.04.096
Publikováno v:
Drug Development and Industrial Pharmacy. 25:361-365
The thermal and peroxide-catalyzed degradation products of mycophenolate mofetil (1) were studied in aqueous solution at pH 2.0, 3.5, 6.0, and 8.2. The major thermal degradation product observed was mycophenolic acid (2). At pH 6.0 and 8.2, 2 was the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09ad9d64550e1cbcf0ecfe01eb1e6fb
https://doi.org/10.1081/ddc-100102183
https://doi.org/10.1081/ddc-100102183
Autor:
David Lustig, Elfatih Elzein, Rao Kalla, Xiaofen Li, Dewan Zeng, Art Gimbel, Kwan Leung, Thao Perry, Jeff Zablocki
Publikováno v:
Journal of medicinal chemistry. 51(7)
Recently, we have reported a series of new 1,3-symmetrically (R 1 = R 3) substituted xanthines ( 3 and 4) which have high affinity and selectivity for the human adenosine A 2B receptors (hA(2B)-AdoR). Unfortunately, this class of compounds had poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b088faec147c713e7ea581a3e8c1d25c
https://pubmed.ncbi.nlm.nih.gov/18321039
https://pubmed.ncbi.nlm.nih.gov/18321039
Autor:
Kevin D. Shenk, Heather Fraser, Khing Jow Ng, Jia Hao, David Lustig, Elfatih Elzein, Timothy A. Marquart, Suresh S. Kerwar, Dmitry Koltun, Daniel Soohoo, Dewan Zeng, Nancy Chu, Victoria Y. Maydanik, Marie Nguyen, Yuan Li, Jeffery A. Zablocki
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(2)
New inhibitors of palmitoylCoA oxidation were synthesized based on a structurally novel lead, CVT-3501 (1). Investigation of structure-activity relationships was conducted with respect to potency of inhibition of cardiac mitochondrial palmitoylCoA ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfdc56cbc14bfeeb7bdb17df44a93ae
https://pubmed.ncbi.nlm.nih.gov/14698201
https://pubmed.ncbi.nlm.nih.gov/14698201
Autor:
Elfatih Elzein, Rao V. Kalla, Xiaofen Li, Thao Perry, Art Gimbel, Dewan Zeng, David Lustig, Kwan Leung, Jeff Zablocki
Publikováno v:
Journal of Medicinal Chemistry; Mar2008, Vol. 51 Issue 7, p2267-2278, 12p