Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David Lukac"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract PARP inhibitors (PARPi), known for their ability to induce replication gaps and accelerate replication forks, have become potent agents in anticancer therapy. However, the molecular mechanism underlying PARPi-induced fork acceleration has re
Externí odkaz:
https://doaj.org/article/c691f30f70f94a50969a491090516dfb
Autor:
Tereza Buchtova, Zdenek Skrott, Katarina Chroma, Jiri Rehulka, Petr Dzubak, Marian Hajduch, David Lukac, Stefanos Arampatzis, Jiri Bartek, Martin Mistrik
Publikováno v:
Molecular Oncology, Vol 16, Iss 7, Pp 1541-1554 (2022)
Disulfiram (DSF), an established alcohol‐aversion drug, is a candidate for repurposing in cancer treatment. DSF’s antitumor activity is supported by preclinical studies, case reports, and small clinical trials; however, ongoing clinical trials of
Externí odkaz:
https://doaj.org/article/3191b1b97405485c86205c2179ad7bf2
Publikováno v:
Life science alliance. 5(12)
DNA synthesis of the leading and lagging strands works independently and cells tolerate single-stranded DNA generated during strand uncoupling if it is protected by RPA molecules. Natural alkaloid emetine is used as a specific inhibitor of lagging st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4207e63260112e1ad556333e5cc9826
https://pubmed.ncbi.nlm.nih.gov/36260751
https://pubmed.ncbi.nlm.nih.gov/36260751
Publikováno v:
International Journal of Molecular Sciences. 24:2885
Cannabidiol (CBD) is an easily accessible and affordable Marijuana (Cannabis sativa L.) plant derivative with an extensive history of medical use spanning thousands of years. Interest in the therapeutic potential of CBD has increased in recent years,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2190782b4ca22d89deba56e92303f0
https://doi.org/10.3390/ijms24032885
https://doi.org/10.3390/ijms24032885
Autor:
David Lukac, Katarina Chroma, Jiri Bartek, Marian Hajduch, Jiri Rehulka, Stefanos Arampatzis, Zdenek Skrott, Petr Dzubak, Martin Mistrik, Tereza Buchtova
Publikováno v:
Molecular oncology. 16(7)
Disulfiram (DSF), an established alcohol-aversion drug, is a candidate for repurposing in cancer treatment. DSF's antitumor activity is supported by preclinical studies, case reports, and small clinical trials; however, ongoing clinical trials of adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631b8e2b36e2ee157ff0f05aca6b67c3
https://pubmed.ncbi.nlm.nih.gov/34632694
https://pubmed.ncbi.nlm.nih.gov/34632694
Autor:
Martin Mistrik, Tereza Buchtova, Katarina Chroma, Marian Hajduch, Jiri Rehulka, Jiri Bartek, Petr Dzubak, Zdenek Skrott, Stefanos Arampatzis, David Lukac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf9407d91bc6ecad58e4e05c9233f76
https://doi.org/10.1002/1878-0261.13114/v2/response1
https://doi.org/10.1002/1878-0261.13114/v2/response1
Autor:
Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTDNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies across different probes. Previous research primarily assessed probe reliability by comp
Externí odkaz:
https://doaj.org/article/4ce06caaeaea44738879447256113558
Autor:
Sara Pierre-Ferrer, Ben Collins, David Lukacsovich, Shao’Ang Wen, Yuchen Cai, Jochen Winterer, Jun Yan, Lene Pedersen, Csaba Földy, Steven A. Brown
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114220- (2024)
Summary: The suprachiasmatic nucleus (SCN) encodes time of day through changes in daily firing; however, the molecular mechanisms by which the SCN times behavior are not fully understood. To identify factors that could encode day/night differences in
Externí odkaz:
https://doaj.org/article/576ac02ce84442c3ba83dada9a5e989f
Autor:
Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Eden R. Martin, Lily Wang
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Growing evidence has demonstrated that DNA methylation (DNAm) plays an important role in Alzheimer’s disease (AD) and that DNAm differences can be detected in the blood of AD subjects. Most studies have correlated blood DNAm wit
Externí odkaz:
https://doaj.org/article/ae8faa0469a948dca7ff5ab04c03229a
Autor:
Gyöngyi Cinege, Lilla B. Magyar, Attila L. Kovács, Zita Lerner, Gábor Juhász, David Lukacsovich, Jochen Winterer, Tamás Lukacsovich, Zoltán Hegedűs, Éva Kurucz, Dan Hultmark, Csaba Földy, István Andó
Publikováno v:
Journal of Innate Immunity, Pp 1-20 (2021)
Multinucleated giant hemocytes (MGHs) represent a novel type of blood cell in insects that participate in a highly efficient immune response against parasitoid wasps involving isolation and killing of the parasite. Previously, we showed that circulat
Externí odkaz:
https://doaj.org/article/de772a7c3fba4482b02f904924d5e6b0