Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David Lowne"'
Autor:
Ian Gurrell, David Lowne, Frank Porreca, Caroline M. Kopruszinski, Edita Navratilova, Philip Newton, Joanne Arnold, Claire Dobson, Peter E. Thornton, David W. Dodick, Iain Chessell, Juliana Swiokla
Publikováno v:
Cephalalgia : an international journal of headache. 40(14)
Aim Migraine pain is thought to result from activation of meningeal nociceptors that might involve dural mast cell degranulation and release of proteases and pronociceptive mediators. Tryptase, the most abundant dural mast cell protease, has been dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c9ffda909a1eb203b52aad387828c9
https://pubmed.ncbi.nlm.nih.gov/33131305
https://pubmed.ncbi.nlm.nih.gov/33131305
Autor:
Tristan J. Vaughan, Fraser Welsh, Paul W. A. Devine, Joanne Goodman, Anna Aagaard, Jonathan J. Phillips, David C. Lowe, Sheena E. Radford, Peter E. Thornton, Matthew G. Iadanza, Andrew Buchanan, Alistair D. Kippen, Lise-Lotte Olsson, Christopher F. van der Walle, Bojana Popovic, David Lowne, Chris Lloyd, Arthur Lewis, Clare L. Pashley, Joanne Arnold, Daniel R. Higazi, Neil A. Ranson, Claire Dobson, Anna Ridderstad Wollberg, Lisa Marie Kitching Vinall, Alison E. Ashcroft, Theodoros K. Karamanos
Publikováno v:
Scientific Reports
'Scientific Reports ', vol: 6, pages: 38644-1-38644-14 (2016)
'Scientific Reports ', vol: 6, pages: 38644-1-38644-14 (2016)
Uncontrolled self-association is a major challenge in the exploitation of proteins as therapeutics. Here we describe the development of a structural proteomics approach to identify the amino acids responsible for aberrant self-association of monoclon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008d85256068f837467fe08671382ce2
https://doi.org/10.1038/srep38644
https://doi.org/10.1038/srep38644
Autor:
Ricardo J. Carreira, Bent K. Jakobsen, Michael J. Cundell, David Lowne, Geert P.M. Mommen, Floriana Capuano, Alex Powlesland, Jacob Hurst
Publikováno v:
Cancer Immunology Research. 7:B086-B086
Purpose of Study: In this study we demonstrate accurate prediction of the impact of somatic mutations on the HLA presentation landscape achieved by interrogating a large scale database of 1.4 million unique HLA peptide sequences that have been direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e44b483d8eb894f4488845dc1bee7a
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b086
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b086
Autor:
Ralph Minter, Judith L. Thijs, David Lowne, Nathaniel C Gordon, DirkJan Hijnen, Cathy Joberty-Candotti, Lutz Jermutus, Carla A.F.M. Bruijnzeel-Koomen, Richard D. May, Carole Urbach, Athula Herath, Florian Hollfelder, Ian Strickland
Publikováno v:
Chemistry & Biology, 22(11), 1442. Cell Press
Summary The practical realization of disease modulation by catalytic degradation of a therapeutic target protein suffers from the difficulty to identify candidate proteases, or to engineer their specificity. We identified 23 measurable, specific, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0110bc7abbc5ca0b1004a6f4b18abc6
https://dspace.library.uu.nl/handle/1874/332782
https://dspace.library.uu.nl/handle/1874/332782
Autor:
Caroline Colley, Christine J. Rossant, Trevor Wilkinson, David Lowne, Joanne Arnold, Sadhana Podichetty, Claire Dobson, Frances Neal, Rob Howes, Tristan J. Vaughan
Publikováno v:
Journal of biomolecular screening. 21(1)
Calcitonin gene-related peptide (CGRP) is a small neuropeptide and a potent vasodilator that is widely associated with chronic pain and migraine. An antibody that inhibits CGRP function would be a potential therapeutic for treatment of these disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6db2d3b87dfc70da13474714bc20559
https://pubmed.ncbi.nlm.nih.gov/26450103
https://pubmed.ncbi.nlm.nih.gov/26450103
Autor:
E. Suzanne Cohen, Phill Monk, Alexis C. Cockroft, Ralph Minter, Andrew Buchanan, Lutz Jermutus, Cathy Joberty Candotti, Celia P. Shorrock-Hart, George Thom, David Lowne
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7619-7624
In this study, we used in vitro protein evolution with ribosome and phage display to optimize the affinity of a human IL-13-neutralizing antibody, a therapeutic candidate for the treatment of asthma, >150-fold to 81 pM by using affinity-driven string
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0b5dbf3ba645407b940c8d84b4c96b
https://doi.org/10.1073/pnas.0602341103
https://doi.org/10.1073/pnas.0602341103
Autor:
Sandrine Guillard, Anders Karlsson, Carl Hay, Robert E. Hollingsworth, Steven Rust, Max Davidson, Kris Sachsenmeier, Roger Karlsson, Ralph Minter, Matt Flynn, Lutz Jermutus, John Elvin, Erin Brand, David Lowne, Gene Kurosawa
Publikováno v:
Molecular Cancer, Vol 12, Iss 1, p 11 (2013)
Molecular Cancer
Molecular Cancer
Background The continued discovery of therapeutic antibodies, which address unmet medical needs, requires the continued discovery of tractable antibody targets. Multiple protein-level target discovery approaches are available and these can be used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6af575072001e64cd8356fbbc789649
http://www.molecular-cancer.com/content/12/1/11
http://www.molecular-cancer.com/content/12/1/11
Autor:
D. Gareth Rees, Maria Groves, Ronald Henry Jackson, Julie A. Douthwaite, Bryan M. Edwards, Steven Lane, David Lowne
Publikováno v:
Journal of immunological methods. 313(1-2)
A comparison has been performed, using phage display or ribosome display, of stringent selections on antibody populations derived from three rounds of phage display selection. Stringent selections were performed by reducing concentrations of the anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c8678a960cc59122cfe0941b567475
https://pubmed.ncbi.nlm.nih.gov/16730741
https://pubmed.ncbi.nlm.nih.gov/16730741
Autor:
Carl Hay, Robert E. Hollingsworth, Lori A. Clarke, Erin Sult, Steven Rust, Sandrine Guillard, Ralph Minter, Matt Flynn, Lutz Jermutus, David Lowne, Kim Rosenthal, Kris Sachsenmeier
Publikováno v:
Cancer Research. 73:4328-4328
Discovery of therapeutic antibodies requires the continued identification of tractable targets, and we have employed a phenotypic screening strategy to this end. In this study, antibodies from phage display libraries were screened for their abilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb85288d79be9fe9737c67d4b1e2c347
https://doi.org/10.1158/1538-7445.am2013-4328
https://doi.org/10.1158/1538-7445.am2013-4328