Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David Loughrey"'
Publikováno v:
Current Research in Biotechnology, Vol 7, Iss , Pp 100200- (2024)
RNA therapeutics are promising for the treatment of lung diseases where small molecules and biologics have failed to have much success in the past. While siRNA and mRNA drugs are now FDA-approved for rare diseases in the liver and as vaccines for inf
Externí odkaz:
https://doaj.org/article/42fbf834800c41f692963451a93972c2
Autor:
Huanzhen Ni, Marine Z. C. Hatit, Kun Zhao, David Loughrey, Melissa P. Lokugamage, Hannah E. Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.
Externí odkaz:
https://doaj.org/article/a3a05515d75242a7919700c5dcde3bf7
Autor:
Zubao Gan, Melissa P. Lokugamage, Marine Z. C. Hatit, David Loughrey, Kalina Paunovska, Manaka Sato, Ana Cristian, James E. Dahlman
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 3, Pp n/a-n/a (2020)
Abstract Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non‐hepatocyte delivery at clinical doses
Externí odkaz:
https://doaj.org/article/09c92bc7ebd54af58ade7073722c4754
Autor:
Marine Z. C. Hatit, Curtis N. Dobrowolski, Melissa P. Lokugamage, David Loughrey, Huanzhen Ni, Chiara Zurla, Alejandro J. Da Silva Sanchez, Afsane Radmand, Sebastian G. Huayamares, Ryan Zenhausern, Kalina Paunovska, Hannah E. Peck, Jinwhan Kim, Manaka Sato, Jacob I. Feldman, Michael-Alexander Rivera, Ana Cristian, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Chemistry. 15:508-515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d411f66312b8f3b3c4db27594a5df3e
https://doi.org/10.1038/s41557-023-01138-9
https://doi.org/10.1038/s41557-023-01138-9
Autor:
Afsane Radmand, Melissa P. Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G. Huayamares, Marine Z. C. Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J. Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nano Letters. 23:993-1002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee5f3aad88116eea784f435311926c8
https://doi.org/10.1021/acs.nanolett.2c04479
https://doi.org/10.1021/acs.nanolett.2c04479
Autor:
Curtis Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri, David Loughrey, Alejandro J. Da Silva Sanchez, Huanzhen Ni, Marine Z. C. Hatit, Melissa P. Lokugamage, Yanina Kuzminich, Hannah E. Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:871-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5beb6a4306e31071e6b7bc2c2cb6f282
https://doi.org/10.1038/s41565-022-01146-9
https://doi.org/10.1038/s41565-022-01146-9
Autor:
Alejandro J. Da Silva Sanchez, Curtis Dobrowolski, Ana Cristian, Elisa Schrader Echeverri, Kun Zhao, Marine Z. C. Hatit, David Loughrey, Kalina Paunovska, James E. Dahlman
Publikováno v:
Nano Letters. 22:4822-4830
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae21db2cb5a0b7c56bef6f97b4676fa
https://doi.org/10.1021/acs.nanolett.2c01133
https://doi.org/10.1021/acs.nanolett.2c01133
Autor:
Cory D. Sago, Melissa P. Lokugamage, David Loughrey, Kevin E. Lindsay, Robert Hincapie, Brandon R. Krupczak, Sujay Kalathoor, Manaka Sato, Elisa Schrader Echeverri, Jordan P. Fitzgerald, Zubao Gan, Lena Gamboa, Kalina Paunovska, Carlos A. Sanhueza, Marine Z. C. Hatit, M. G. Finn, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Biomedical Engineering. 6:157-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e8d05bf56456cbf86e57da6eb41c3f7
https://doi.org/10.1038/s41551-022-00847-9
https://doi.org/10.1038/s41551-022-00847-9
Autor:
Marine Z. C. Hatit, Melissa P. Lokugamage, Curtis N. Dobrowolski, Kalina Paunovska, Huanzhen Ni, Kun Zhao, Daryll Vanover, Jared Beyersdorf, Hannah E. Peck, David Loughrey, Manaka Sato, Ana Cristian, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:310-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff65c7ba59890ec94d1cb948b4e910f
https://doi.org/10.1038/s41565-021-01030-y
https://doi.org/10.1038/s41565-021-01030-y
Autor:
Alejandro J, Da Silva Sanchez, Curtis, Dobrowolski, Ana, Cristian, Elisa Schrader, Echeverri, Kun, Zhao, Marine Z C, Hatit, David, Loughrey, Kalina, Paunovska, James E, Dahlman
Publikováno v:
Nano letters. 22(12)
To predict whether preclinical lipid nanoparticle (LNP) delivery will translate in humans, it is necessary to understand whether the mechanism used by LNPs to enter cells is conserved across species. In mice, non-human primates, and humans, LNPs deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aff745b0e01add6696a41a669ec396d7
https://pubmed.ncbi.nlm.nih.gov/35671473
https://pubmed.ncbi.nlm.nih.gov/35671473