Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David Lopez Martinez"'
Autor:
Marian Kupculak, Fengxiang Bai, Qiang Luo, Yasunaga Yoshikawa, David Lopez-Martinez, Hannan Xu, Stephan Uphoff, Martin A. Cohn
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112721- (2023)
Summary: The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs) in humans. Activation of the pathway relies on loading of the FANCD2/FANCI complex onto chromosomes, where it is fully activated by subsequent monoubiquitination. Howe
Externí odkaz:
https://doaj.org/article/ba597a99322445818a2950a95af9733c
Autor:
David Lopez-Martinez, Marian Kupculak, Di Yang, Yasunaga Yoshikawa, Chih-Chao Liang, Ronghu Wu, Steven P. Gygi, Martin A. Cohn
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2990-3005.e5 (2019)
Summary: Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the pathway is the FANCD2/FANCI complex, recruitment of which to DNA is a critical step
Externí odkaz:
https://doaj.org/article/8b1b2e0eb6dc4f549943a994d0233d7e
Autor:
Chih-Chao Liang, Zhuolun Li, David Lopez-Martinez, William V. Nicholson, Catherine Vénien-Bryan, Martin A. Cohn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2-FANCI complex, providing insight into how the complex is recruited to stalled replication forks.
Externí odkaz:
https://doaj.org/article/c919cf65091d44ba84e82fd2b5331de6
Autor:
Anna Motnenko, Chih-Chao Liang, Di Yang, David Lopez-Martinez, Yasunaga Yoshikawa, Bao Zhan, Katherine E Ward, Jiayang Tian, Wilhelm Haas, Paolo Spingardi, Benedikt M Kessler, Skirmantas Kriaucionis, Steven P Gygi, Martin A Cohn
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007643 (2018)
The Fanconi Anemia (FA) pathway is important for repairing interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix. An initial and essential stage in the repair process is the detection of the ICL. Here, we report the i
Externí odkaz:
https://doaj.org/article/0732015a852349df980e56c133ef0fcb
Autor:
Maria-Armineh Tossounian, Christopher Thrasivoulou, David Lopez Martinez, Bess Yi Kun Yu, Jovana Baković, Ivan Gout, Valeriy Filonenko, Savvas Nikolaou, Yugo Tsuchiya
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 1131, p 1131 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1131, p 1131 (2021)
Volume 22
Issue 3
Coenzyme A (CoA) is an essential cofactor present in all living cells. Under physiological conditions, CoA mainly functions to generate metabolically active CoA thioesters, which are indispensable for cellular metabolism, the regulation of gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ecc79f91726387d2cfc7628fbdfe07
https://doi.org/10.3390/ijms22031131
https://doi.org/10.3390/ijms22031131
Publikováno v:
Cellular and Molecular Life Sciences
Interstrand crosslinks (ICLs) are a highly toxic form of DNA damage. ICLs can interfere with vital biological processes requiring separation of the two DNA strands, such as replication and transcription. If ICLs are left unrepaired, it can lead to mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1ad05bc3fb1f23feb4522772500d14
http://europepmc.org/articles/PMC4951507
http://europepmc.org/articles/PMC4951507
Autor:
Alexis Vander Biest, David Lopez Martinez, Erwan Leroy, Frédéric Robert, Antoine Nonclercq, Kevin De Cuyper
Publikováno v:
IEEE Transactions on Education. 53:234-242
As part of an instrumentation course, a problem-based learning framework was selected for laboratory instruction. Two acquisition chains were designed to help students carry out realistic instrumentation problems. The first tool is a virtual (simulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4f50ddcc2caefef17d9b025d5bf075
https://doi.org/10.1109/te.2009.2013716
https://doi.org/10.1109/te.2009.2013716
Autor:
Chih-Chao Liang, Jamie Langton, Andrew J. Deans, Fenil Shah, Richard J. Gibbons, Martin A. Cohn, Jadwiga Nieminuszczy, Wojciech Niedzwiedz, Rebekka A. Schwab, David Lopez Martinez
Publikováno v:
Molecular cell. 60(3)
DNA replication stress can cause chromosomal instability and tumor progression. One key pathway that counteracts replication stress and promotes faithful DNA replication consists of the Fanconi anemia (FA) proteins. However, how these proteins limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3a621f5d5230b24f3f0930a1d83b2c
https://pubmed.ncbi.nlm.nih.gov/26563463
https://pubmed.ncbi.nlm.nih.gov/26563463
Publikováno v:
Biochemical Society transactions. 42(4)
CoA (coenzyme A) is an essential cofactor in all living organisms. CoA and its thioester derivatives [acetyl-CoA, malonyl-CoA, HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) etc.] participate in diverse anabolic and catabolic pathways, allosteric regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5fa9e2df27e3b2a16fed41b643ce66
https://pubmed.ncbi.nlm.nih.gov/25110011
https://pubmed.ncbi.nlm.nih.gov/25110011