Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David Looper"'
Autor:
Xinmeng Jasmine Mu, Meirong Xu, Shahram Salek-Ardakani, Cinthia Costa-Jones, Lisa Nguyen, James Solowiej, David Looper, Scott L. Weinrich, Robert Louis Hoffman, Sutton Scott Channing, Sacha Ninkovic, Kephart Susan Elizabeth, Sherry Niessen, John Chionis, Jadwiga Bienkowska, Kevin Daniel Freeman-Cook, Rose Ann Ferre, John Lapek, Cecilia Oderup, Jordan Carelli, Cathy Zhang, Nanni Huser, Elizabeth A. McMillan, Asako Nagata, Martha A. Ornelas, Brion W. Murray, Douglas Carl Behenna, Koleen Eisele, Todd VanArsdale, Zhou Zhu, Zhengyan Kan, Chaoting Liu, Nichol Miller, Zehnder Luke Raymond, Michael A. White, Ying Ding, Nathan V. Lee, Jonathan Almaden, Qin Zhang, Tran Khanh Tuan, Ping Wei, Stephen Dann, Britton Boras, Tim S. Wang, Ravi Visswanathan, You-Ai He, Michele McTigue, Elizabeth Wilson
Publikováno v:
Cancer Cell. 39:1404-1421.e11
Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to discover PAL resistance mechanisms in preclinical models and through analys
Autor:
Karen Siegel, Helen Kim Cho, David Looper, Shawn C Black, Xiao-Hong Yu, Scott Rp McDonnell, Dawn Kelly-Sullivan, Sergei Timofeevski, Junming Yie, Celia P. Briscoe, Kathleen M. Ogilvie, Ping Chen, Manli Shi, James S. Fraser
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E1142-E1151
c-Jun NH2-terminal kinase (JNK) plays an important role in insulin resistance; however, identification of pharmacologically potent and selective small molecule JNK inhibitors has been limited. Compound A has a cell IC50 of 102 nM and is at least 100-
Autor:
B. Ganesh Bhat, Phong Tran, David Looper, Scott Rp McDonnell, Celia P. Briscoe, Jocelyn Herrera
Publikováno v:
Biochemical and Biophysical Research Communications. 361:140-145
The contribution of nutrient overload and associated inflammation to insulin resistance has highlighted several therapeutic targets including c-Jun N-terminal kinase (JNK) and S6 kinase (S6K). To investigate how a lipopolysaccharide (LPS)-mediated in
Autor:
David W. Kang, Monica L. Zepeda, Barry J. Sugarman, Erlinda Quijano, Danling Gu, L. David Looper
Publikováno v:
Molecular Therapy. 13
Excessive scarring is a significant clinical problem, resulting in both adverse tissue form and function. We have previously demonstrated that a recombinant adenovirus encoding the cyclin-dependent kinase inhibitor p21 (rAd-p21), attenuated cell prol
Autor:
David W. Kang, C. M. I. Ahmed, Danling Gu, L. David Looper, Alina Levy, Isabella A. Atencio, Monica L. Zepeda, Dan Maneval
Publikováno v:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 13(5)
Excessive cutaneous scarring is an important clinical disorder resulting in adverse tissue growth and function as well as undesirable cosmetic appearance. p21WAF-1/Cip-1 is a cyclin-dependent kinase inhibitor that blocks cell cycle progression and in
Autor:
Erlinda Quijano, Danling Gu, David W. Kang, Monica L. Zepeda, David Looper, Shu Fen Wen, Diane McAllister
Publikováno v:
Molecular Therapy. 11:S290-S291
Understanding where genes are being expressed in normal, wounded and wound impaired skin, along with the duration of expression after transduction by recombinant adenovirus (rAd) is an important factor relevant to gene therapy strategies. Recombinant
Autor:
Jitesh P. Jani, David Looper, Suijin Yang, Nowlin Dawn Marie, Wei Tan, Zhongdong Huang, Gerrit Los
Publikováno v:
Cancer Research. 71:305-305
EphB4 belongs to the Eph Receptor Tyrosine Kinase family. EphB4 regulates angiogenesis, neuron migration and breast morphogenesis. Overexpression of EphB4 has been observed in numerous cancer types, including breast, ovarian and prostate cancers. How
Autor:
Zhong, Wenyan1 (AUTHOR) wenyan.zhong@pfizer.com, Myers, Jeremy S.1 (AUTHOR), Wang, Fang1 (AUTHOR), Wang, Kai2 (AUTHOR), Lucas, Justin1 (AUTHOR), Rosfjord, Edward1 (AUTHOR), Lucas, Judy1 (AUTHOR), Hooper, Andrea T.1 (AUTHOR), Yang, Sharon1 (AUTHOR), Lemon, Lu Anna1 (AUTHOR), Guffroy, Magali3 (AUTHOR), May, Chad1 (AUTHOR), Bienkowska, Jadwiga R.2 (AUTHOR), Rejto, Paul A.2 (AUTHOR) paul.rejto@pfizer.com
Publikováno v:
BMC Genomics. 1/2/2020, Vol. 21 Issue 1, p1-17. 17p. 2 Color Photographs, 2 Diagrams, 2 Charts, 2 Graphs.
Autor:
Inman, Natalie1
Publikováno v:
Journal of Florida Studies. 2019, Vol. 1 Issue 8, p1-15. 15p.
Autor:
Thomas, Jason jthomas@scbiznews.com
Publikováno v:
Columbia Regional Business Report. Nov2023, Vol. 16 Issue 11, p14-14. 2/3p.