Zobrazeno 1 - 10
of 91
pro vyhledávání: '"David Lok"'
Autor:
Joseph Chung Yan Chan, Connie Irene Diakos, Alexander Engel, David Lok Hang Chan, Nick Pavlakis, Anthony Gill, Stephen John Clarke
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/408231ea7f2846b09a4e253328411f0b
Autor:
Joseph Chung Yan Chan, Connie Irene Diakos, Alexander Engel, David Lok Hang Chan, Nick Pavlakis, Anthony Gill, Stephen John Clarke
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228466 (2020)
AimsInflammation is a hallmark of cancer whose activity is modulated within the tumor microenvironment by low tumoral pH. Recent evidence in the literature has suggested a link between low serum bicarbonate, low tumoral pH and cancer related inflamma
Externí odkaz:
https://doaj.org/article/c7149188944f4d7887e2404127324f25
Autor:
Wing-Hoi Cheung, Wan-Yiu Shen, David Lok-Kwan Dai, Kin Bong Lee, Tracy Y. Zhu, Ronald Man-Yeung Wong, Kwok-Sui Leung
Publikováno v:
Journal of Rehabilitation Medicine, Vol 50, Iss 3, Pp 285-291 (2017)
Objective: To investigate the effectiveness and cost of an 18-month multi-disciplinary Comprehensive Fragility Fracture Management Program (CFFMP) for fragility hip fracture patients. Design: Prospective cohort study. Patients: Elderly patients wit
Externí odkaz:
https://doaj.org/article/3da61fc57b7844199f38714b92968851
Autor:
Joseph Chung Yan Chan, Connie Irene Diakos, Alexander Engel, David Lok Hang Chan, Nick Pavlakis, Anthony Gill, Stephen John Clarke
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218207 (2019)
BackgroundRecent literature has suggested that tumor sidedness in colorectal cancer (CRC) is an independent prognostic and potentially predictive marker of survival. The aims of the study were to determine the prognostic significance of tumor sidedne
Externí odkaz:
https://doaj.org/article/804e2bda90644deebfd0d54cecd7f980
Autor:
Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani
Publikováno v:
Journal of Medicinal Chemistry. 64:6902-6923
Stimulator of Interferon Genes (STING) plays an important role in innate immunity by inducing type I interferon production upon infection with intracellular pathogens. STING activation can promote increased T-cell activation and inflammation in the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642868da1ca20f638998dc8a616442f
https://doi.org/10.1021/acs.jmedchem.1c00374
https://doi.org/10.1021/acs.jmedchem.1c00374
Autor:
Pere Dosta, Alexander M. Cryer, Michelle Z. Dion, Tsubasa Shiraishi, Steven P. Langston, David Lok, Jianing Wang, Sean Harrison, Shiran Ferber, Santhosh Kalash, Michaela Prado, Alma L. Rodríguez, Adnan O. Abu-Yousif, Natalie Artzi
Stimulator of interferon genes (STING) agonist is a promising activator of antitumor immunity. However, the systemic delivery of STING agonist, based on cyclic dinucleotides (CDNs), yields limited anticancer activity owing to poor serum stability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c600aad6a1daa959876f75ce8524808a
https://doi.org/10.21203/rs.3.rs-1647238/v1
https://doi.org/10.21203/rs.3.rs-1647238/v1
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5159f216a3701336ba4dda4e3a9836
https://pubmed.ncbi.nlm.nih.gov/33631934
https://pubmed.ncbi.nlm.nih.gov/33631934
Akademický článek
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Autor:
Chan, Joseph Chung Yan, Diakos, Connie Irene, Engel, Alexander, Chan, David Lok Hang, Pavlakis, Nick, Gill, Anthony, Clarke, Stephen John
Publikováno v:
PLoS ONE; 8/5/2021, Vol. 16 Issue 8, p1-5, 5p
Autor:
Natalie Roy D’Amore, Shih-Chung Huang, Sharmila Adhikari, Dylan England, David Lok, Anna Lublinsky, Jouhara Chouitar, Klaudia Foley, Patrick J. LeRoy, Emily F. Calderwood, Ji Zhang, Alexandra E. Gould, James E. Brownell, Sean J. Harrison, Li-Ting Ma, Yu Yang, Saurabh Menon
Publikováno v:
Bioorganicmedicinal chemistry. 28(19)
Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656b64ba891d9a46f6ea1dbce3e38c14
https://pubmed.ncbi.nlm.nih.gov/32912429
https://pubmed.ncbi.nlm.nih.gov/32912429