Zobrazeno 1 - 10
of 40
pro vyhledávání: '"David Liberg"'
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Autor:
James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflamma
Externí odkaz:
https://doaj.org/article/d1aa83cba4b9429da818f4c99e7a5c77
Autor:
Paramita Chakraborty, Per Bjork, Eva Källberg, Anders Olsson, Matteo Riva, Matthias Mörgelin, David Liberg, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145217 (2015)
We show here, by using surface biotinylation, followed by Western blotting or surface plasmon resonance analysis, that very low levels of S100A8 and/or S100A9 can be detected on the surface of THP-1 cells or freshly isolated human monocytes. This was
Externí odkaz:
https://doaj.org/article/c74b8a3058df4ee681e5829c71f5b885
Autor:
Per Björk, Eva Källberg, Ulf Wellmar, Matteo Riva, Anders Olsson, Zhifei He, Marie Törngren, David Liberg, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63012 (2013)
S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced
Externí odkaz:
https://doaj.org/article/ff3b62ac635a4e5284c72f67383f2f8b
Autor:
Eva Källberg, Thomas Vogl, David Liberg, Anders Olsson, Per Björk, Pernilla Wikström, Anders Bergh, Johannes Roth, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34207 (2012)
By breeding TRAMP mice with S100A9 knock-out (S100A9(-/-)) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression. CD11b(+) S100A9 expressing cells were not observed in normal p
Externí odkaz:
https://doaj.org/article/d85c17eed1b146adad26d0cf47427550
Autor:
Per Björk, Anders Björk, Thomas Vogl, Martin Stenström, David Liberg, Anders Olsson, Johannes Roth, Fredrik Ivars, Tomas Leanderson
Publikováno v:
PLoS Biology, Vol 7, Iss 4, p e97 (2009)
Despite more than 25 years of research, the molecular targets of quinoline-3-carboxamides have been elusive although these compounds are currently in Phase II and III development for treatment of autoimmune/inflammatory diseases in humans. Using phot
Externí odkaz:
https://doaj.org/article/d9b0cf5ec37a4cefa5970058e75fe613
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04187b069721494e99bd1d58846d698c
https://doi.org/10.1136/jitc-2022-sitc2022.0145
https://doi.org/10.1136/jitc-2022-sitc2022.0145
Publikováno v:
Circulation Research. 131
IL-1, IL-33 and IL-36 have complementary, pro-inflammatory roles during the immune response that promote autoimmune diseases, particularly myocarditis. While antibodies that neutralize circulating cytokines exist, we hypothesized that blockade of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0079346453f53ddd61fd0a7fb5406333
https://doi.org/10.1161/res.131.suppl_1.p3061
https://doi.org/10.1161/res.131.suppl_1.p3061
Autor:
Eric Van Cutsem, Joelle Collignon, Rikke Eefsen, Sebastian Ochsenreither, Zanete Zvirbule, Audrius Ivanauskas, Camilla Rydberg Millrud, Petter Skoog, Nedjad Losic, Susanne Magnusson, Annika Sanfridson, David Liberg
Publikováno v:
Cancer Research. 83:2172-2172
Background: Interleukin-1 Receptor Accessory Protein (IL1RAP) is expressed on cancer and stromal cells in pancreatic ductal adenocarcinoma (PDAC), and high tumor IL1RAP RNA expression is a negative prognostic marker1. Dimerization between IL1RAP and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a1351b3e5149afae682f8050682f70
https://doi.org/10.1158/1538-7445.am2023-2172
https://doi.org/10.1158/1538-7445.am2023-2172
Autor:
Camilla Rydberg Millrud, Adnan Deronic, Caitríona Grönberg, Elin Jaensson Gyllenbäck, Karin von Wachenfeldt, Göran Forsberg, David Liberg
Publikováno v:
Cancer immunology, immunotherapy : CII.
IL-1α and IL-1β are both involved in several aspects of tumor biology, including tumor initiation, progression, metastasis, and not least in resistance to various therapies. IL-1α can function as an alarmin to signal cellular stress, and acts to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95515910a2c5158d9e71a9dbc4a77eef
https://pubmed.ncbi.nlm.nih.gov/36036818
https://pubmed.ncbi.nlm.nih.gov/36036818
Autor:
Debbie Robbrecht, Christiane Jungels, Morten Mau Sorensen, Iben Spanggaard, Ferry Eskens, Signe Ø Fretland, Tormod Kyrre Guren, Philippe Aftimos, David Liberg, Christer Svedman, Lars Thorsson, Neeltje Steeghs, Ahmad Awada
Publikováno v:
British Journal of Cancer, 126(7), 1010-1017. Nature Publishing Group
Br J Cancer
Br J Cancer
Background: Interleukin-1 (IL-1) signalling is involved in various protumoural processes including proliferation, immune evasion, metastasis and chemoresistance. CAN04 is a first-in-class monoclonal antibody that binds IL-1 receptor accessory protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36fe8599641d77b894744932ed8951a
https://pure.eur.nl/en/publications/85dcc1fa-305e-46a4-889d-c10cef4ff14a
https://pure.eur.nl/en/publications/85dcc1fa-305e-46a4-889d-c10cef4ff14a
