Výsledky vyhledávání - "David Leuthold"

The Eco‐Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals

Publikováno v: Environmental toxicology and chemistry 41(1), 30-45 (2022). doi:10.1002/etc.5242

Organisms are exposed to ever‐changing complex mixtures of chemicals over the course of their lifetime. The need to more comprehensively describe this exposure and relate it to adverse health effects has led to formulation of the exposome concept i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3268dd209cdb51a0780a9a6a5439b0f
http://resolver.sub.uni-goettingen.de/purl?gldocs-11858/9885

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Can Environmentally Relevant Neuroactive Chemicals Specifically Be Detected with the Locomotor Response Test in Zebrafish Embryos?

Autor: David Leuthold, Wibke Busch, Rolf Altenburger, Nils Klüver

Publikováno v: Environmental Science & Technology. 53:482-493

Chemicals considered as neuroactive (such as certain pesticides, pharmaceuticals, and industrial chemicals) are among the largest groups of bioactive substances recently detected in European rivers. However, the determination of nervous-system-specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d116b6635d8e4c5b8b88ebfad5016f
https://doi.org/10.1021/acs.est.8b04327

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Transcriptome-Wide Prediction and Measurement of Combined Effects Induced by Chemical Mixture Exposure in Zebrafish Embryos

Autor: M. Krauss, J.M. Fix, Janet Krüger, Rolf Altenburger, David Leuthold, Andreas Schüttler, Wibke Busch, Gianina Jakobs

Publikováno v: Environmental Health Perspectives

Background: Humans and environmental organisms are constantly exposed to complex mixtures of chemicals. Extending our knowledge about the combined effects of chemicals is thus essential for assessing the potential consequences of these exposures. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311bdf1c9661c762e037ecc1fd7db0d0
https://pubmed.ncbi.nlm.nih.gov/34609158

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Comparative assessment of the sensitivity of fish early-life stage, daphnia and algae to the chronic ecotoxicity of xenobiotics - perspectives for alternatives to animal testing

Autor: Marc Léonard, Elisabet Teixidó, Noémie De Croze, Stefan Scholz, David Leuthold

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

No-observed-effect concentrations (NOECs) are used in environmental hazard classification and labeling of chemicals and their environmental risk assessment. They are typically obtained using standard tests such as the fish early-life stage (FELS) tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e40780c5e1fe3d92249207d71ae4be3
http://hdl.handle.net/2445/165756

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Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes

Autor: Afolarin O. Ogungbemi, David Leuthold, Stefan Scholz, Eberhard Küster

Publikováno v: Environmental Sciences Europe. 31

Tests with zebrafish embryos have gained wide acceptance as an alternative test model for drug development and toxicity testing. In particular, the behavioral response of the zebrafish embryo is currently seen as a useful endpoint to diagnose neuroac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ccd0762f27908536b4caceb35e17213
https://doi.org/10.1186/s12302-019-0270-5

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An ecotoxicological view on neurotoxicity assessment

Publikováno v: Environmental Sciences Europe
European Journal of Environmental Sciences
European Journal of Environmental Sciences, Charles University in Prague, 2018, 30, pp.1-34. ⟨10.1186/s12302-018-0173-x⟩
Environmental Sciences Europe (2190-4715) (Springeropen), 2018-12, Vol. 30, N. 46, P. 34p.
Environmental Sciences Europe, Vol 30, Iss 1, Pp 1-34 (2018)
Environmental Sciences Europe, 2018, 30
Environmental sciences Europe : ESEU 30(1), 46 (2018). doi:10.1186/s12302-018-0173-x special issue: "Special Issue 20 Years SETAC GLB / Edited by: Jochen Zubrod, Bettina Hitzfeld, Marion Junghans, Anja Kehrer, Rolf Düring, Peter Ebke, Dominic Kaiser, Anja Kehrer, Silvio Knaebe, Nadine Ruchter, Tobias Frische and Henner Hollert"
Environmental sciences Europe
Legradi, J B, Di Paolo, C, Kraak, M H S, van der Geest, H G, Schymanski, E L, Williams, A J, Dingemans, M M L, Massei, R, Brack, W, Cousin, X, Begout, M L, van der Oost, R, Carion, A, Suarez-Ulloa, V, Silvestre, F, Escher, B I, Engwall, M, Nilén, G, Keiter, S H, Pollet, D, Waldmann, P, Kienle, C, Werner, I, Haigis, A C, Knapen, D, Vergauwen, L, Spehr, M, Schulz, W, Busch, W, Leuthold, D, Scholz, S, vom Berg, C M, Basu, N, Murphy, C A, Lampert, A, Kuckelkorn, J, Grummt, T & Hollert, H 2018, ' An ecotoxicological view on neurotoxicity assessment ', Environmental Sciences Europe, vol. 30, 46, pp. 1-34 . https://doi.org/10.1186/s12302-018-0173-x
European Journal of Environmental Sciences (30), 1-34. (2018)
European Journal of Environmental Sciences, 2018, 30, pp.1-34. ⟨10.1186/s12302-018-0173-x⟩

International audience; The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a9c198b973bf997fc4b7b6a389580c
http://europepmc.org/articles/PMC6292971

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