Zobrazeno 1 - 10
of 25
pro vyhledávání: '"David Laughton"'
Autor:
Hélène Asnagli, Norbert Minet, Christina Pfeiffer, Eef Hoeben, Rebecca Lane, David Laughton, Louise Birch, Geraint Jones, Andrew Novak, Andrew E. Parker, Heinz Ludwig, Alain Fischer, Sylvain Latour, Philip A. Beer
Publikováno v:
HemaSphere, Vol 7, Iss 4, p e864 (2023)
Lymphoma is the most common hematological malignancy and is among the 10 most prevalent cancers worldwide. Although survival has been improved by modern immunochemotherapeutic regimens, there remains a significant need for novel targeted agents to tr
Externí odkaz:
https://doaj.org/article/94c683a95284402c9f04f59bf749bdad
Autor:
Andrew Novak, David Laughton, Rebecca Lane, Emma Blackham, Jennifer Thomas, Elli Chatzopoulou, Joseph Wrigglesworth, Abdul Quddus, Saleh Ahmed, David Cousin, Lorna Duffy, Nathalie Dubois, John Unitt, Katalin Orban, Edward Browne, Michelle Ward, David Mycock, Maria Ieva, Nicholas Bland, Pascal George, Timothy Bourne, Hélène Asnagli, Louise Birch, Geraint Jones
Publikováno v:
Journal of Medicinal Chemistry. 65:16640-16650
Herein, we report the discovery of a first-in-class chemotype 2-(alkylsulfonamido)thiazol-4-yl)acetamides that act as pan-selective inhibitors of cytidine 5'-triphosphate synthetase (CTPS1/2), critical enzymes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ef9951f3a13e9255109c54a35d4764
https://doi.org/10.1021/acs.jmedchem.2c01446
https://doi.org/10.1021/acs.jmedchem.2c01446
Autor:
Norbert Minet, Anne-Claire Boschat, Rebecca Lane, David Laughton, Philip Beer, Hélène Asnagli, Claire Soudais, Tim Bourne, Alain Fischer, Emmanuel Martin, Sylvain Latour
The CTP nucleotide is a key precursor of nucleic acids metabolism essential for DNA replication. De novo CTP production relies on CTP synthetases 1 and 2 (CTPS1 and 2) that catalyze the conversion of UTP into CTP. CTP synthetase activity is high in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::191fbc7ee65c62b2ee82bfe5d795a53d
https://doi.org/10.1101/2023.03.29.534741
https://doi.org/10.1101/2023.03.29.534741
Autor:
David Laughton
Publikováno v:
Higher Education, Skills and Work-Based Learning. 1:231-246
PurposeThe purpose of this paper is to explore the aims, objectives and approach to change adopted by the e3i CETL for Employability at Sheffield Hallam University and illustrates the impact of change via three thematic case studies and an organising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2936cd0999434f45117bce5d6dd13919
https://doi.org/10.1108/20423891111179632
https://doi.org/10.1108/20423891111179632
Publikováno v:
Engineering Geology. 108:54-64
Carbonate sands undergo degradation when transported hydraulically from a dredging vessel to the reclamation site. Risks involved in the production of fines during hydraulic transport are a deterioration of the mechanical properties of the fill in ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b163fe45e647d5f6e7ab5f2e3f74c8a
https://doi.org/10.1016/j.enggeo.2009.06.005
https://doi.org/10.1016/j.enggeo.2009.06.005
Autor:
Simon Barber, John Unitt, David Laughton, Fraser Hunt, Sarah King, Bob Thong, Andrew Baxter, Denise Grice, Alastair J. H. Brown, Garry Pairaudeau, Hitesh J. Sanganee, Richard J. Weaver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1143-1147
A novel series of small molecule C5a antagonists is reported. In particular, in vitro metabolic studies and solution based combinatorial synthesis are demonstrated as useful tools for the rapid identification of antagonists with low in vitro clearanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c845beadbca4f62c0827d86827abdd7
https://doi.org/10.1016/j.bmcl.2008.12.104
https://doi.org/10.1016/j.bmcl.2008.12.104
Autor:
David Laughton, Roger Ottewill
Publikováno v:
Educational Action Research. 11:429-446
The development of corporate leadership skills is seen as a crucial ingredient of management education programmes in higher education. Moreover, with the increasing globalisation of business activity, the education of those who will ultimately occupy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::220bc5375d3ef9f1d258561587b0322c
https://doi.org/10.1080/09650790300200231
https://doi.org/10.1080/09650790300200231
Autor:
David Laughton
Publikováno v:
Assessment & Evaluation in Higher Education. 28:309-321
This article will review and evaluate the response of academics working in higher education institutions (HEIs) in the UK to the experience of teaching quality review. It will do so by gathering the viewpoints and opinions of academics from a particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d08301342e37b04959dc02cfdfd1c41
https://doi.org/10.1080/0260293032000059658
https://doi.org/10.1080/0260293032000059658
Autor:
David Laughton, Roger Ottewill
Publikováno v:
Journal of Teaching in International Business. 12:1-22
The increasing globalization of business means that those responsible for educating tomorrow's managers must give priority to the development of “cross-cultural capability,” comprising an ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ae21b8c19e3dbc072c5851262c9784
https://doi.org/10.1300/j066v12n01_01
https://doi.org/10.1300/j066v12n01_01
Autor:
Adrian M.R. Haines, Andrew Mountain, Rhonda Husain, Abdu Amir, Lawrence S. Young, Peter K.E. Trinder, Ruth H. McDermott, Alistair Simpson Irvine, Sophie C.H. Reid, Rajeev Doshi, David Laughton, Helen Ketteringham
Publikováno v:
Nature Biotechnology. 18:1273-1278
Immunization with dendritic cells (DCs) transfected with genes encoding tumor-associated antigens (TAAs) is a highly promising approach to cancer immunotherapy. We have developed a system, using complexes of plasmid DNA expression constructs with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166606cd67a053ac4fec3f859499091f
https://doi.org/10.1038/82383
https://doi.org/10.1038/82383