Zobrazeno 1 - 10
of 237
pro vyhledávání: '"David Lau"'
Publikováno v:
Annals of Vascular Surgery - Brief Reports and Innovations, Vol 4, Iss 1, Pp 100246- (2024)
Aortoiliac occlusive disease is a common cause of claudication symptoms. When complicated by extensive calcification, successful angioplasty and resolution of symptoms may be difficult to achieve. Several plaque-modifying therapies have been develope
Externí odkaz:
https://doaj.org/article/becc162ae3214e1d80e32eec59ea0c9c
Autor:
Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond
Publikováno v:
Neurobiology of Disease, Vol 189, Iss , Pp 106360- (2023)
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD). A previous study showed Activin A, whose transcription is upr
Externí odkaz:
https://doaj.org/article/04dd3efbeedd46cd91625a37365c615f
Autor:
Ming Kwan Kwan, David Lau
Publikováno v:
Journal on Tourism & Sustainability, Vol 6, Iss 2 (2023)
Environmental education experience in parks has been neglected in literature. This study aims to explore environmental and sustainable educational experiences of visitors in Hong Kong Ma Wan Park where is a nature park that combines nature, learning,
Externí odkaz:
https://doaj.org/article/d22aef09fbe04cf88936d33876b2cd97
Publikováno v:
Buildings, Vol 13, Iss 3, p 747 (2023)
This study first provides an overview of the development of a novel tube anchor system for the seismic strengthening or repair of reinforced concrete (RC) shear walls with carbon fibre-reinforced polymer (CFRP) sheets. The new anchor system can signi
Externí odkaz:
https://doaj.org/article/7bbdb54ff9dc44c9938eb1a498c186c2
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contr
Externí odkaz:
https://doaj.org/article/d007fae61eb245b79d5afc68f45e4648
Autor:
Léa Décarie-Spain, Cécile Hryhorczuk, David Lau, Élizabeth Jacob-Brassard, Alexandre Fisette, Stephanie Fulton
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100324- (2021)
Obesity significantly increases the risk for anxiety and depression. Our group has recently demonstrated a role for nucleus accumbens (NAc) pro-inflammatory nuclear factor kappa-B (NFkB) signaling in the development of anxiodepressive-like behaviors
Externí odkaz:
https://doaj.org/article/f8a128055b774a3184fb938eb7f3a9b8
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1353-1366 (2015)
The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors. Here, we show that BDNF is a regulator of this balance and promotes neuroprotection by
Externí odkaz:
https://doaj.org/article/cd7288d8f0b54e38967aa4c2c7f2cc51
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8364 (2009)
The down-regulation of the major histocompatibility complex class I (MHC-I) from the surface of infected cells by the Nef proteins of primate immunodeficiency viruses likely contributes to pathogenesis by providing evasion of cell-mediated immunity.
Externí odkaz:
https://doaj.org/article/1c07314777174b8586e37ea3845fc7ff
Autor:
Sheng-Jia Zhang, Ming Zou, Li Lu, David Lau, Désirée A W Ditzel, Celine Delucinge-Vivier, Yoshinori Aso, Patrick Descombes, Hilmar Bading
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000604 (2009)
Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show that in hippocampal neurons nuclear calcium is one of the most potent signals in neur
Externí odkaz:
https://doaj.org/article/9aae7c1aff934434b4ff87cf3ff64ae6
Autor:
Richard S Mitchell, Chris Katsura, Mark A Skasko, Katie Fitzpatrick, David Lau, Autumn Ruiz, Edward B Stephens, Florence Margottin-Goguet, Richard Benarous, John C Guatelli
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000450 (2009)
The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the
Externí odkaz:
https://doaj.org/article/9f2e60a5427f440ca85621752c99e315