Zobrazeno 1 - 10
of 41
pro vyhledávání: '"David Lathbury"'
Autor:
Trevor Laird, Jaan A. Pesti, Ahmed F. Abdel-Magid, Daniel Levin, Tony Y. Zhang, Sean P. Lapekas, Thomas Archibald, Stephen M. Stefanick, Ryo Sugiyama, Toru Yamano, Joerg Deerberg, Stefan Abele, Gunther Schmidt, Jacques-Alexis Funel, Mischa Schwaninger, Sven Wagner, Noel A. Hamill, Mark E. Howells, James H. Simpson, Atul S. Kotnis, Rajendra P. Deshpande, David J. Kacsur, Jason Hamm, Gus Kodersha, William Merkl, Daniel Domina, Steve Y. Wang, Nicholas A. Straessler, Louis F. Cannizzo, Michael W. Lesley, Oliver R. Thiel, John R. Huckins, Derek B. Brown, Eric A. Bercot, John T. Colyer, Bobby Riahi, Rob R. Milburn, Steve M. Shaw, Joe Tomaskevitch, David J. Ager, Ayman Allian, Bryan Li, Steven Guinness, L. Mleczko, Dongbo Zhao, Sripathy Venkatraman, Scott Tweedie, Mark McLaws, David Lathbury
Autor:
David Lathbury, David S. Ennis
As a molecule progresses from discovery into clinical development, drug discovery chemists will hand over their development candidate and its synthetic route to a chemical development group. The quality of that handover can have a big influence on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1b7359de61e74d369d28d96c3400aed
https://doi.org/10.1039/9781782621836-00592
https://doi.org/10.1039/9781782621836-00592
Publikováno v:
ACS Symposium Series ISBN: 9780841230330
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed60c68a6bd2ad263b5a910af2b805bb
https://doi.org/10.1021/bk-2014-1181.ch016
https://doi.org/10.1021/bk-2014-1181.ch016
Autor:
Laurence C. Powling, David S. Ennis, David Lathbury, Mark A. Armitage, Paul D. Blackler, Nigel Hussain, Graham H. Oakes, Noah O'Connor, David O. Morgan, Richard K. Bellingham, and Stephen C. Passey, Karl W. Ace
Publikováno v:
Organic Process Research & Development. 5:479-490
A literature route to 1-(2-{4-[(E)-1-(4-iodophenyl)-2-phenyl-but-1-enyl]phenoxy}ethyl)pyrrolidine (idoxifene) has been modified to tackle various scale-up issues and provide initial supplies. A new highly efficient, robust, and stereoselective manufa
Publikováno v:
Tetrahedron: Asymmetry. 8:673-676
Asymmetric reduction of enones 1a-g using either a stoichiometric or catalytic amount of oxazaborolidine 3 proceeds to give the synthetically useful allylic cycloalkanols 2a-g in 83–96% e.e.
Autor:
Joseph F. Hudner, Graham S. Macaulay, Robert A. Stockman, Timothy Harvey, Charles R. White, Roderick John Dorgan, David Lathbury, Lewis Norman John, David O. Morgan, Nigel Hussain, Ian P. Andrews
Publikováno v:
Tetrahedron Letters. 37:4811-4814
A 6-step synthesis of the potent anthelmintic SB-201561 is described. The key stage of the synthesis is a novel Beckmann type oxime fragmentation to give a lactone, followed by a 2-step reassembly of the spirolcetal moiety.
Publikováno v:
Tetrahedron Letters. 36:8141-8144
The α-diazo esters (6) and (7) react, in the absence of any catalyst, with a variety of HONR2 and HONCR2 compounds to give the 0-alkylated adducts (8) to (16). In particular, reaction of (7) with N-hydroxyphthalimide in refluxing benzene followed by
Publikováno v:
Tetrahedron Letters. 36:6957-6960
Summary A synthesis of lactam 2 , which constitutes a formal total synthesis of (−)-slaframine 1 , is described with key steps being (a) intramolecular aldol reaction of ketoaldehyde 4 to establish the indolizidine framework and (b) diastereoselect
Autor:
Andy Wells, David Lathbury
Publikováno v:
Organic Process Research & Development. 19:1536-1536
Publikováno v:
ChemInform. 22
The synthesis and stereocontrolled AgI-catalysed cyclisation of a series of allenic amino esters 8a–e is described. For compounds 8a–d the cis-2,5-disubstituted pyrrolidine 9 is formed exclusively but the primary amine 8e undergoes cyclisation no