Zobrazeno 1 - 10
of 52
pro vyhledávání: '"David Lara-Astiaso"'
Autor:
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutat
Externí odkaz:
https://doaj.org/article/e4df0207a07b4df791d9fb4bec0b4c62
Autor:
Rodrigo Entrialgo-Cadierno, Cristina Cueto-Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi-Salaverri, David Lara-Astiaso, Nils Halberg, Ivan Cortes-Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023)
Abstract Background The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or mechanisms amenable to inhibition strategies. Phospholipids availability has b
Externí odkaz:
https://doaj.org/article/4f6be978317d4dc0ae3c2a262e7964af
Autor:
Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing
Externí odkaz:
https://doaj.org/article/5a52f5ed769d4553afa3673e2f1e7052
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101770- (2022)
Summary: Recurrent gene mutations often cooperate in a predefined stepwise and synergistic manner to alter global transcription, through directly or indirectly remodeling epigenetic landscape on linear and three-dimensional (3D) scales. Here, we pres
Externí odkaz:
https://doaj.org/article/0d755c75cfb44d0181e7fd5ef22661e0
Autor:
Rodrigo Entrialgo‑Cadierno, Cristina Cueto‑Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi‑Salaverri, David Lara‑Astiaso, Nils Halberg, Ivan Cortes‑Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/05018549b48a4e08a6c7bb8bdcca3266
Autor:
Nerea Zabaleta, Miren Barberia, Cristina Martin-Higueras, Natalia Zapata-Linares, Isabel Betancor, Saray Rodriguez, Rebeca Martinez-Turrillas, Laura Torella, Africa Vales, Cristina Olagüe, Amaia Vilas-Zornoza, Laura Castro-Labrador, David Lara-Astiaso, Felipe Prosper, Eduardo Salido, Gloria Gonzalez-Aseguinolaza, Juan R. Rodriguez-Madoz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Substrate reduction therapies (SRT) are a promising therapeutic approach for monogenic inherited metabolic diseases. Here the authors evaluate the therapeutic potential of an in vivo CRISPR/Cas9-mediated SRT to treat primary hyperoxaluria type I and
Externí odkaz:
https://doaj.org/article/4b179c1567b1437ea464d69ab6bf5455
Autor:
Daniel Alameda, Borja Saez, David Lara-Astiaso, Sarai Sarvide, Marta Lasa, Diego Alignani, Idoia Rodriguez, Sonia Garate, Amaia Vilas, Bruno Paiva, Matias Alfonso-Olmos, Jose Maria Lamo de Espinosa, Felipe Prosper, Jesus F. San Miguel, Patricia Maiso
Publikováno v:
Haematologica, Vol 105, Iss 9 (2020)
Externí odkaz:
https://doaj.org/article/229b3097755843fb95fdd43460522b44
Autor:
Goren Saenz-Pipaon, Patxi San Martín, Núria Planell, Alberto Maillo, Susana Ravassa, Amaia Vilas-Zornoza, Esther Martinez-Aguilar, José Antonio Rodriguez, Daniel Alameda, David Lara-Astiaso, Felipe Prosper, José Antonio Paramo, Josune Orbe, David Gomez-Cabrero, Carmen Roncal
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Peripheral arterial disease (PAD) is associated with a high risk of cardiovascular events and death and is postulated to be a critical socioeconomic cost in the future. Extracellular vesicles (EVs) have emerged as potential candidates for new biomark
Externí odkaz:
https://doaj.org/article/2571a4225cb14860afdd7c2eb331c1f5
Autor:
Ignacio Gil-Bazo, Silvestre Vicent, Ignacio I. Wistuba, Walter Weder, Carmen Behrens, Simona Taverna, Luis E. Raez, Edgardo S. Santos, Christian Rolfo, Mariano Ponz-Sarvise, David Lara-Astiaso, Amaia Vilas-Zornoza, Laura Castro-Labrador, Patxi San Martin-Uriz, Jae Hwi Jang, Marta Echavarri-de Miguel, Silvia Cadenas, Adrián Vallejo, Ernest Nadal, María Collantes, Margarita Ecay, Iosune Baraibar, Elisabeth Guruceaga, Inés López, Marta Román
An Id1 gene signature is dependent of KEAP1-related genes and a FOSL1 network.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a2a261ad9dd9b18c2f7dc4c1149ba5
https://doi.org/10.1158/0008-5472.22421925
https://doi.org/10.1158/0008-5472.22421925
Autor:
Ignacio Gil-Bazo, Silvestre Vicent, Ignacio I. Wistuba, Walter Weder, Carmen Behrens, Simona Taverna, Luis E. Raez, Edgardo S. Santos, Christian Rolfo, Mariano Ponz-Sarvise, David Lara-Astiaso, Amaia Vilas-Zornoza, Laura Castro-Labrador, Patxi San Martin-Uriz, Jae Hwi Jang, Marta Echavarri-de Miguel, Silvia Cadenas, Adrián Vallejo, Ernest Nadal, María Collantes, Margarita Ecay, Iosune Baraibar, Elisabeth Guruceaga, Inés López, Marta Román
Clinical implication of Id1 expression in LUAD patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f311c18e3437bfdc72a854ec58ef3d
https://doi.org/10.1158/0008-5472.22421931.v1
https://doi.org/10.1158/0008-5472.22421931.v1