Zobrazeno 1 - 10 of 142 pro vyhledávání: '"David Lambeth"'
1
Akademický článek
Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival.
Autor: Juan A De La Cruz, Thota Ganesh, Becky A Diebold, Weiping Cao, Amelia Hofstetter, Neetu Singh, Amrita Kumar, James McCoy, Priya Ranjan, Susan M E Smith, Suryaprakash Sambhara, J David Lambeth, Shivaprakash Gangappa
Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0254632 (2021)
Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on in
Externí odkaz: https://doaj.org/article/80b3ccda96934ff1811aa0a4c2c44104
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2
Akademický článek
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.
Autor: Amelia R Hofstetter, Juan A De La Cruz, Weiping Cao, Jenish Patel, Jessica A Belser, James McCoy, Justine S Liepkalns, Samuel Amoah, Guangjie Cheng, Priya Ranjan, Becky A Diebold, Wun-Ju Shieh, Sherif Zaki, Jacqueline M Katz, Suryaprakash Sambhara, J David Lambeth, Shivaprakash Gangappa
Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149864 (2016)
The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, N
Externí odkaz: https://doaj.org/article/614eb1488bae42bd80588d4074854175
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3
Akademický článek
Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons.
Autor: Keifer P Walsh, Laurie S Minamide, Sarah J Kane, Alisa E Shaw, David R Brown, Bruce Pulford, Mark D Zabel, J David Lambeth, Thomas B Kuhn, James R Bamburg
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95995 (2014)
Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in
Externí odkaz: https://doaj.org/article/a3df7ff5157a402b8837a2ab94fa9b44
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4
Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival
Autor: Weiping Cao, Juan A. De La Cruz, Becky A. Diebold, Neetu Singh, James McCoy, Amelia R. Hofstetter, Priya Ranjan, Thota Ganesh, Suryaprakash Sambhara, Amrita Kumar, Susan M.E. Smith, Shivaprakash Gangappa, J. David Lambeth
Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254632 (2021)
Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In thisin vitrostudy, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on infl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d07c212eda0716c305281a090d3173e
https://doi.org/10.1371/journal.pone.0254632
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5
Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR
Autor: James Jh Doroshow, James Jw McCoy, S Garrett Wilder, David Lambeth, Yerun Zhu, Jennifer Jl Meitzler, Becky Ba Diebold, Xavier De Deken
Publikováno v: Methods in Molecular Biology ISBN: 9781493994236
Methods Mol Biol
The identification of NADPH oxidase (NOX) isoforms in tissues is essential for interpreting experiments and for next step decisions regarding cell lines, animal models, and targeted drug design. Two basic methods, immunoblotting and reverse transcrip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4624c4ce7d11f8cf9651a8c08dc2b5a4
https://doi.org/10.1007/978-1-4939-9424-3_12
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6
Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation
Autor: Lynn VerPlank, Balaraman Kalyanaraman, Jacek Zielonka, Olivier Ouari, Radosław Podsiadły, Monika Zielonka, J. David Lambeth, Gang Cheng, Mehmet Menaf Ayhan, Adam Sikora, Micael Hardy
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291, pp.7029-7044. ⟨10.1074/jbc.M115.702787⟩
Journal of Biological Chemistry, 2016, 291, pp.7029-7044. ⟨10.1074/jbc.M115.702787⟩
Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library of bioactive compounds. By using multiple probes (hydroethidine, hydro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaeb47228111c2e44875990bb9d14c3
https://doi.org/10.1074/jbc.m115.702787
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7
Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase
Autor: Thota Ganesh, Yerun Zhu, Susan M.E. Smith, Yang Li, J. David Lambeth, Aiming Sun, Becky A. Diebold, James McCoy
Publikováno v: ACS Medicinal Chemistry Letters. 6:1047-1052
Myeloperoxidase (MPO) is a key antimicrobial enzyme, playing a normal role in host defense, but also contributing to inflammatory conditions including neuroinflammatory diseases such as Parkinson's and Alzheimer's. We synthesized and characterized mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd4b4ae6df0b5da8332297b99e60f43
https://doi.org/10.1021/acsmedchemlett.5b00287
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9
High-throughput Assays for Superoxide and Hydrogen Peroxide
Autor: Gang Cheng, Monika Zielonka, Jacek Zielonka, Balaraman Kalyanaraman, William J. O'Brien, Aiming Sun, Radosław Michalski, J. David Lambeth, Joy Joseph, Thota Ganesh
Publikováno v: Journal of Biological Chemistry. 289:16176-16189
Recent progress characterizing the reaction mechanism(s) of fluorescent probes with reactive oxygen species has made it possible to rigorously analyze these reactive species in biological systems. We have developed rapid high throughput-compatible as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04a9338810b864cf4d7285375aff3666
https://doi.org/10.1074/jbc.m114.548693
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10
On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation
Autor: Jacek Zielonka, J. David Lambeth, Balaraman Kalyanaraman
Publikováno v: Free Radical Biology and Medicine. 65:1310-1314
L-012, a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2(*-)) and identify Nox inhibitors. Yet understanding of the free radical chemistry of the L-012 probe is still
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd42ca792e3549464b228688cd10bceb
https://doi.org/10.1016/j.freeradbiomed.2013.09.017
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