Zobrazeno 1 - 10 of 51 pro vyhledávání: '"David L.J. Tyrrell"'
1
Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-di-AMP, a STING activator or archaeosomes
Autor: Michael Logan, Juthika Kundu, David L.J. Tyrrell, Abdolamir Landi, Chao Chen, Carlos A. Guzmán, John Lok Man Law, Darren Hockman, Michael Houghton, Lise Deschatelets, Lakshmi Krishnan, T. Ebensen, Kevin Crawford
Publikováno v: Vaccine. 35(50)
Three decades after the discovery, hepatitis C virus (HCV) is still the leading cause of liver transplantation and poses a major threat to global health. In spite of recent advances in the development of direct acting antivirals, there is still a nee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd43a2ef5cb4e571f200ea3287ccf3c
https://pubmed.ncbi.nlm.nih.gov/29089195
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2
cDNA cloning, genomic structure, molecular characterization and mRNA expression analysis of the Pekin duck interleukin-10 receptor 1
Autor: David L.J. Tyrrell, Klaus S. Gutfreund, Q. Yao, Karl P. Fischer
Publikováno v: International Journal of Immunogenetics. 39:55-67
Interleukin-10 (IL-10) mediates its broad anti-inflammatory and immunoregulatory effects through two cell surface receptors by which binding to the IL-10 receptor 1 (IL-10R1) is the initial step that leads to recruitment of IL-10R2 and initiation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::747c4bdfb191d192500d54b151e6055d
https://doi.org/10.1111/j.1744-313x.2011.01058.x
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5
Capillary electrophoresis-electrospray-mass spectrometry of nucleosides and nucleotides: Application to phosphorylation studies of anti-human immunodeficiency virus nucleosides in a human hepatoma cell line
Autor: Charles C. Liu, Jyy S. Huang, Norman J. Dovichi, David L.J. Tyrrell
Publikováno v: ELECTROPHORESIS. 26:1424-1431
We report the use of capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) for the determination of antiretroviral dideoxynucleosides (ddNs), their nucleotides, and a set of ribonucleosides and ribonucleotides. A CE system f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038f11cd318400b7385c4c035cdda043
https://doi.org/10.1002/elps.200410423
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6
TRAIL Inhibits Tumor Growth but Is Nontoxic to Human Hepatocytes in Chimeric Mice
Autor: Jamie T. Lewis, Chunhai Hao, Jin H. Song, David L.J. Tyrrell, Belinda Hsi, Doyoun K. Song, Norman M. Kneteman, Kenneth C. Petruk
Publikováno v: Cancer Research. 64:8502-8506
Tumor necrosis factor (TNF) family ligand TNF-α and Fas ligand (FasL) can trigger apoptosis in solid tumors, but their clinical usage has been limited by hepatotoxicity. TNF-related apoptosis-inducing ligand (TRAIL) is a newly identified member of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3baaba46c4f1ce2fb0904cccd7d9e6
https://doi.org/10.1158/0008-5472.can-04-2599
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7
Quantitative polymerase chain reaction using capillary electrophoresis with laser-induced fluorescence detection: Analysis of duck hepatitis B
Autor: Norman J. Dovichi, Roger Y. Tsang, Woei G. Tan, David L.J. Tyrrell, Nan Li
Publikováno v: Analytical and Bioanalytical Chemistry. 374:269-273
We report an accurate and reproducible DNA quantitation method using the polymerase chain reaction (PCR). The amount of PCR product is monitored after each PCR cycle by capillary electrophoresis. To ensure accurate quantitation, a non-amplified inter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373011bbba58a35b3b319ce1f3987e7d
https://doi.org/10.1007/s00216-002-1468-7
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8
The Pekin duck programmed death-ligand 1: cDNA cloning, genomic structure, molecular characterization and mRNA expression analysis
Autor: Klaus S. Gutfreund, Q. Yao, Karl P. Fischer, David L.J. Tyrrell
Publikováno v: International journal of immunogenetics. 42(2)
Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa932ffbdcbe2e6d4a1e4d80698e8a4
https://pubmed.ncbi.nlm.nih.gov/25556810
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9
Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance
Autor: Klaus S. Gutfreund, Mang Ma, Jean-Pierre Villeneuve, Vincent G. Bain, David L.J. Tyrrell, Karl P. Fischer, Eric M. Yoshida, Mark Williams, Rajan George
Publikováno v: Journal of Hepatology. 33:469-475
Background/Aims: Hepatitis B mutant strains of virus emerging during treatment with the nucleoside analog lamivudine are being increasingly recognized. In the majority of lamivudine-resistant isolates the mutations have been reported to occur within
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a65745a58a87189b5ca27ae5e052e2
https://doi.org/10.1016/s0168-8278(00)80284-6
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10
Identification and characterization of mutations in hepatitis B virus resistant to lamivudine
Autor: C W Andrews, Lynn D. Condreay, Kathie-Anne Walters, Graham Tipples, David L.J. Tyrrell, Nathaniel A. Brown, Marchelle I. Allen, Manon Deslauriers
Publikováno v: Hepatology. 27:1670-1677
Cirrhosis and hepatocellular carcinoma occur as long-term complications of chronic hepatitis B virus (HBV) infection. Antiviral therapy is potentially a successful approach for the treatment of patients with HBV infection, which includes the nucleosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f69a6ac7bf6b1b042b85c8091834c307
https://doi.org/10.1002/hep.510270628
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