Výsledky vyhledávání - "David L. Zeng"

Retrospective statistical analysis of lyophilized protein formulations of progenipoietin using PLS: Determination of the critical parameters for long-term storage stability

Autor: John D. Ludwig, Hong Qi, Robert E. Johnson, David L. Zeng, Derrick S. Katayama, Borgmeyer Jeffry, Carrie M. Elliott, Barrett R. Thiele, Carol F. Kirchhoff, Mark C. Manning

Publikováno v: Journal of Pharmaceutical Sciences. 93:2609-2623

Although certain criteria have become recognized as being essential for a stable lyophilized formulation, the relative importance of different stability criteria has not been demonstrated quantitatively. This study uses multivariate statistical metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f957773c05f9554e70f97eadd75ea2
https://doi.org/10.1002/jps.20170

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Use of combinatorial mutagenesis to select for multiply substituted human interleukin-3 variants with improved pharmacologic properties

Autor: Jeng-Jong Shieh, Peter O. Olins, Maire Helena Caparon, William F. Hood, Kumnan Paik, Ann M. Donnelly, Bauer Christopher S, John P. McKearn, Sarah R. Braford, Polazzi Joseph O, John W. Thomas, Jon A. Klover, Alan Michael Easton, David L. Zeng, Mark Allen Abrams, Joseph K. Welply, Barbara K. Klein

Publikováno v: Experimental Hematology. 27:1746-1756

A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid substitutions clustered within four linear, nonoverlapping regions of the polypeptide. The va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4c1a8be21dd8999107c60b154356b0
https://doi.org/10.1016/s0301-472x(99)00118-6

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Purification and characterization of progenipoietins produced in Escherichia. coli

Autor: Violand Bernard N, Yiqing G. Feng, Kristin E Thomas, John C. Minnerly, Joseph O. Polazzi, Karl J. Mathis, David L. Zeng

Publikováno v: Protein expression and purification. 26(2)

The progenipoietins (ProGPs) are a family of genetically engineered chimeric proteins that contain receptor agonist activity for both fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor. These unique proteins have pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15138bc402865fc01082b86a314f30db
https://pubmed.ncbi.nlm.nih.gov/12406682

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