Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David L. Wensel"'
Autor:
David R. Langley, Rick L. Pieschl, John Watson, Simon Low, Linda J. Bristow, Debra J. Post-Munson, Michael K. Ahlijanian, Ramkumar Rajamani, Sophie Wu, James Herrington, Mian Gao, Lisa Megson, Iyoncy Rodrigo, David L. Wensel
Publikováno v:
Molecular Pharmacology. 92:310-317
The NaV1.7 voltage-gated sodium channel is implicated in human pain perception by genetics. Rare gain of function mutations in NaV1.7 lead to spontaneous pain in humans whereas loss of function mutations results in congenital insensitivity to pain. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07940ab23c226013ba900bf2c7333fa2
https://doi.org/10.1124/mol.117.108712
https://doi.org/10.1124/mol.117.108712
Autor:
Thomas McDonagh, David L. Wensel, Sebastien Tabruyn, Zhufang Li, Tracy S. Mitchell, Jonathan H. Davis, Yongnian Sun, Sharon Zhang, Mark Krystal, Mark I. Cockett, Patrick Nef, David R. Langley
Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with adnectins targeting CD4 and gp41, a potential long-acting biologic, GSK3732394, was developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17986092965a8eab3c5db82a28136fd
https://europepmc.org/articles/PMC6798092/
https://europepmc.org/articles/PMC6798092/
Autor:
John Hynes, Gardner Daniel S, Max Ruzanov, Martin C. Wright, Ruchira Das Gupta, John V. Duncia, Katie A. Russo, Yongmi An, Cullen L. Cavallaro, Aneka Bell, Eric T. Baldwin, Mian Gao, David L. Wensel, Daniel M. Camac, Javed Khan, Victoria Jenny, Pallavi Gambhire, Simon Low, James William Bryson, Julie Su, Andrew J. Tebben
Publikováno v:
Journal of Molecular Biology. 427(4):924-942
The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide variety of xenobiotics and regulates expression of several drug metabolizing enzymes and transporters. We have generated "Adnectins", derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf348c50de47ceb50208fd4fea0b121e
Autor:
Mark Krystal, Sharon Zhang, Caryn Picarillo, Thomas McDonagh, Jonathan H. Davis, David Fabrizio, Zhufang Li, David L. Wensel, Yongnian Sun, Mark I. Cockett
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
A novel fibronectin-based protein (Adnectin) HIV-1 inhibitor was generated using in vitro selection. This inhibitor binds to human CD4 with a high affinity (3.9 nM) and inhibits viral entry at a step after CD4 engagement and preceding membrane fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a565f2431eb4e13013d02bf9d0d3b8
https://doi.org/10.1128/aac.00508-17
https://doi.org/10.1128/aac.00508-17
Publikováno v:
Biotechnology and Bioengineering. 100:839-854
High-throughput screening (HTS) of chromatography resins for identifying optimal protein purification conditions is becoming an integral part of industrial process development. In this work, ceramic hydroxyapatite (cHA) chromatography of 15 humanized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428b4505ef1dd27f17395ac0c95a5b3c
https://doi.org/10.1002/bit.21906
https://doi.org/10.1002/bit.21906
During ongoing C-type retrovirus infection, the probability of leukemia caused by insertional gene activation is markedly increased by the emergence of recombinant retroviruses that repeatedly infect host cells. The murine mink cell focus-inducing (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5539ea6d4a185981f740a94a0c31ca11
https://europepmc.org/articles/PMC149514/
https://europepmc.org/articles/PMC149514/