Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David L. Shen"'
Autor:
Matthew C. Deen, Yanping Zhu, Christina Gros, Na Na, Pierre-André Gilormini, David L. Shen, Sandeep Bhosale, Nadia Anastasi, RuiQi Wang, Xiaoyang Shan, Eva Harde, Ravi Jagasia, Francis C. Lynn, David J. Vocadlo
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Loss of activity of the lysosomal glycosidase β-glucocerebrosidase (GCase) causes the lysosomal storage disease Gaucher disease (GD) and has emerged as the greatest genetic risk factor for the development of both Parkinson disease (PD) and dementia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0113bca08bd05ac62b44bc1768f3cf2a
https://doi.org/10.1073/pnas.2200553119
https://doi.org/10.1073/pnas.2200553119
Autor:
Adam McCluskey, Hong‐Yee Tan, Richard W. Meek, Gontran Sangouard, Matthew G. Alteen, David A. Cardoso, Gideon J. Davies, Cecilia C. Russell, Matthew C. Deen, Phillip J. Robinson, David L. Shen, David J. Vocadlo, Jil A. Busmann, Christina Gros
Glycosyltransferases carry out important cellular functions in species ranging from bacteria to humans. Despite their essential roles in biology, simple and robust activity assays that can be easily applied to high-throughput screening for inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ae43c5b3b52190baf080b2c0a17ff1
https://eprints.whiterose.ac.uk/159729/1/Accepted_Article_Alteen_Manuscript_Feb22.pdf
https://eprints.whiterose.ac.uk/159729/1/Accepted_Article_Alteen_Manuscript_Feb22.pdf
Autor:
Cameron Proceviat, Xiaoyang Shan, Matthew C. Deen, Gideon J. Davies, David J. Vocadlo, David L. Shen, Liang Wu
Within mammals, there are often several functionally related glycoside hydrolases, which makes monitoring their activities problematic. This problem is particularly acute for the enzyme β-glucocerebrosidase (GCase), the malfunction of which is a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342b47e122812cee9a0f515434bfeb6d
http://summit.sfu.ca/item/20487
http://summit.sfu.ca/item/20487
Autor:
David L. Shen, Matthew G. Alteen, Razieh Eskandari, Hong Yee Tan, Lianne I. Willems, Zarina Madden, Ta-Wei Liu, David J. Vocadlo, Yanping Zhu
The modification of proteins with O-linked N-acetylglucosamine ( O-GlcNAc) by the enzyme O-GlcNAc transferase (OGT) has emerged as an important regulator of cellular physiology. Metabolic labeling strategies to monitor O-GlcNAcylation in cells have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413bcf1b7ca50411f82dae51eb7769f1
https://eprints.whiterose.ac.uk/138310/1/Tan_JACS_2018_accepted_manuscript.docx
https://eprints.whiterose.ac.uk/138310/1/Tan_JACS_2018_accepted_manuscript.docx
Glucocerebrosidase (GCase) is a lysosomal glycoside hydrolase that cleaves the glycolipid glucosylceramide (GlcCer). Deficiencies of this enzyme lead to accumulation of GlcCer and the development of the lysosomal storage disease known as Gaucher's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::084a25631feab75569c74c1cf59812be
https://doi.org/10.1016/bs.mie.2017.06.014
https://doi.org/10.1016/bs.mie.2017.06.014
Autor:
Thomas Clark, Wesley F. Zandberg, Yanping Zhu, Ta-Wei Liu, Hong Yee Tan, Matthew G. Alteen, David J. Vocadlo, David L. Shen, Razieh Eskandari, Samy Cecioni
O-GlcNAc transferase (OGT) catalyzes the installation of N-acetylglucosamine (GlcNAc) O-linked to nucleocytoplasmic proteins (O-GlcNAc) within multicellular eukaryotes. OGT shows surprising tolerance for structural changes in the sugar component of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959abc7d5c4f3c55b44bd3c83f4370f8
http://summit.sfu.ca/item/20482
http://summit.sfu.ca/item/20482
Publikováno v:
Transportation Research Record: Journal of the Transportation Research Board. 2105:109-117
Hurricanes or other natural disasters often result in damage to and disruption of transportation systems that are critical to relief and recovery efforts. For this reason, it is important for the general public and elected officials to know the opera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5d5189010f5848220646a17c3e7783
https://doi.org/10.3141/2105-14
https://doi.org/10.3141/2105-14
Autor:
David J. Vocadlo, David L. Shen, Subramaniapillai Kolappan, Ernest J. McEachern, Renee Mosi, Jianyu Sun, Lisa Craig
Lactate dehydrogenase (LDH) is an essential metabolic enzyme that catalyzes the interconversion of pyruvate and lactate using NADH/NAD+as a co-substrate. Many cancer cells exhibit a glycolytic phenotype known as the Warburg effect, in which elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f33be9666e2fcba9f28dea840485577
http://summit.sfu.ca/item/20481
http://summit.sfu.ca/item/20481
Publikováno v:
Journal of the American Chemical Society. 137(3)
Deficiency of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) leads to abnormal accumulation of glucosyl ceramide in lysosomes and the development of the lysosomal storage disease known as Gaucher’s disease. More recently, mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23e7844f9460bdca61999c2ef7633ef
https://pubmed.ncbi.nlm.nih.gov/25562638
https://pubmed.ncbi.nlm.nih.gov/25562638
Publikováno v:
Journal of the Transportation Research Forum. 49
Traffic signal warrants set the minimum conditions under which a traffic signal installation may be appropriate. The four-hour volume signal warrant in the current Manual on Uniform Traffic Control Devices (MUTCD) (FHWA 2009) is applied based on a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::950a24575c1a1d97e7213103deace3c5
https://doi.org/10.5399/osu/jtrf.49.3.2561
https://doi.org/10.5399/osu/jtrf.49.3.2561