Zobrazeno 1 - 10
of 935
pro vyhledávání: '"David L. Rimm"'
Autor:
Sandra Martinez-Morilla, Myrto Moutafi, Aileen I. Fernandez, Shlomit Jessel, Prajan Divakar, Pok Fai Wong, Rolando Garcia-Milian, Kurt A. Schalper, Harriet M. Kluger, David L. Rimm
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTAlthough immune checkpoint inhibitor (ICI) therapy has dramatically improved outcome for metastatic melanoma patients, many patients do not benefit. Since adverse events may be severe, biomarkers for resistance would be valuable, especially i
Externí odkaz:
https://doaj.org/article/61850931c801456bb2e5a14b003e557a
Autor:
Cristian Barrera, Germán Corredor, Vidya Sankar Viswanathan, Ruiwen Ding, Paula Toro, Pingfu Fu, Christina Buzzy, Cheng Lu, Priya Velu, Philipp Zens, Sabina Berezowska, Merzu Belete, David Balli, Han Chang, Vipul Baxi, Konstantinos Syrigos, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Eduardo Romero, Anant Madabhushi
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-17 (2023)
Abstract The tumor immune composition influences prognosis and treatment sensitivity in lung cancer. The presence of effective adaptive immune responses is associated with increased clinical benefit after immune checkpoint blockers. Conversely, immun
Externí odkaz:
https://doaj.org/article/7c0ca7f73bbc4c88a4b7179f0cbb1a5c
Autor:
Kristina A. Fanucci, Yalai Bai, Vasiliki Pelekanou, Zeina A. Nahleh, Saba Shafi, Sneha Burela, William E. Barlow, Priyanka Sharma, Alastair M. Thompson, Andrew K. Godwin, David L. Rimm, Gabriel N. Hortobagyi, Yihan Liu, Leona Wang, Wei Wei, Lajos Pusztai, Kim R. M. Blenman
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract We assessed the predictive value of an image analysis-based tumor-infiltrating lymphocytes (TILs) score for pathologic complete response (pCR) and event-free survival in breast cancer (BC). About 113 pretreatment samples were analyzed from p
Externí odkaz:
https://doaj.org/article/de40aac7a42e4da9b372c3f02f74cceb
Autor:
Katherine M. Bates, Ioannis Vathiotis, Tyler MacNeil, Fahad Shabbir Ahmed, Thazin Nwe Aung, Yuliya Katlinskaya, Sabyasachi Bhattacharya, Amanda Psyrri, Steven Yea, Amanda Parkes, Nooshin Hashemi Sadraei, Siddhartha Roychoudhury, David L. Rimm, Niki Gavrielatou
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background CD40, a TNF receptor family member, is expressed by a variety of immune cells and is involved in the activation of both adaptive and innate immune responses. Here, we used quantitative immunofluorescence (QIF) to evaluate CD40 exp
Externí odkaz:
https://doaj.org/article/3fc24253526d4e1f97eca8f21fe3dad0
Autor:
Ioannis A. Vathiotis, Leonidas Salichos, Sandra Martinez-Morilla, Niki Gavrielatou, Thazin Nwe Aung, Saba Shafi, Pok Fai Wong, Shlomit Jessel, Harriet M. Kluger, Konstantinos N. Syrigos, Sarah Warren, Mark Gerstein, David L. Rimm
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)
Abstract Treatment with immune checkpoint inhibitors has altered the course of malignant melanoma, with approximately half of the patients with advanced disease surviving for more than 5 years after diagnosis. Currently, there are no biomarker method
Externí odkaz:
https://doaj.org/article/956f4e8b0c1545fa97bfbb01c858e7bd
Autor:
Taja Lozar, Wei Wang, Niki Gavrielatou, Leslie Christensen, Paul F. Lambert, Paul M. Harari, David L. Rimm, Barbara Burtness, Cvetka Grasic Kuhar, Evie H. Carchman
Publikováno v:
Viruses, Vol 15, Iss 12, p 2320 (2023)
A growing body of literature suggests that the expression of cytokeratin 17 (K17) correlates with inferior clinical outcomes across various cancer types. In this scoping review, we aimed to review and map the available clinical evidence of the progno
Externí odkaz:
https://doaj.org/article/247b4ebf458d4748840980216362d278
Autor:
Eftychia Chatziioannou, Jana Roßner, Thazin New Aung, David L. Rimm, Heike Niessner, Ulrike Keim, Lina Maria Serna-Higuita, Irina Bonzheim, Luis Kuhn Cuellar, Dana Westphal, Julian Steininger, Friedegund Meier, Oltin Tiberiu Pop, Stephan Forchhammer, Lukas Flatz, Thomas Eigentler, Claus Garbe, Martin Röcken, Teresa Amaral, Tobias Sinnberg
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104644- (2023)
Summary: Background: Recent advances in digital pathology have enabled accurate and standardised enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a percentage electronic TIL score (eTILs) and investigate its pro
Externí odkaz:
https://doaj.org/article/35c191c0b266487cb0126f25360675a8
Autor:
Michal Marczyk, Tao Qing, Tess O’Meara, Vesal Yagahoobi, Vasiliki Pelekanou, Yalai Bai, Emily Reisenbichler, Kimberly S. Cole, Xiaotong Li, Vignesh Gunasekharan, Eiman Ibrahim, Kristina Fanucci, Wei Wei, David L. Rimm, Lajos Pusztai, Kim R. M. Blenman
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Differences in the tumor immune microenvironment may result in differences in prognosis and response to treatment in cancer patients. We hypothesized that differences in the tumor immune microenvironment may exist between African American (A
Externí odkaz:
https://doaj.org/article/684458edf8ea4c0394edcc581f66fe7d
Autor:
Ruiwen Ding, Prateek Prasanna, Germán Corredor, Cristian Barrera, Philipp Zens, Cheng Lu, Priya Velu, Patrick Leo, Niha Beig, Haojia Li, Paula Toro, Sabina Berezowska, Vipul Baxi, David Balli, Merzu Belete, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Anant Madabhushi
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract Despite known histological, biological, and clinical differences between lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), relatively little is known about the spatial differences in their corresponding immune contextures. Our s
Externí odkaz:
https://doaj.org/article/49c1fdcecc9740e192e0f9ed3747a376
Autor:
Taja Lozar, Israa Laklouk, Athena E. Golfinos, Niki Gavrielatou, Jin Xu, Christopher Flynn, Aysenur Keske, Menggang Yu, Justine Y. Bruce, Wei Wang, Cvetka Grasic Kuhar, Howard H. Bailey, Paul M. Harari, Huy Q. Dinh, David L. Rimm, Rong Hu, Paul F. Lambert, Megan B. Fitzpatrick
Publikováno v:
Cancers, Vol 15, Iss 19, p 4905 (2023)
Low response rates in immune check-point blockade (ICB)-treated head and neck squamous cell carcinoma (HNSCC) drive a critical need for robust, clinically validated predictive biomarkers. Our group previously showed that stress keratin 17 (CK17) supp
Externí odkaz:
https://doaj.org/article/5c15423f7eb347d0a60f6ff2e7942a5f