Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David L. Rick"'
Publikováno v:
Regulatory Toxicology and Pharmacology. 73:530-543
2-Phenoxyethanol (PhE) has been shown to induce hepatotoxicity, renal toxicity, and hemolysis at dosages ≥ 400 mg/kg/day in subchronic and chronic studies in multiple species. To reduce uncertainty associated with interspecies extrapolations and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01860577b1efd140844b3d5055ae00ee
https://doi.org/10.1016/j.yrtph.2015.07.012
https://doi.org/10.1016/j.yrtph.2015.07.012
Autor:
B. Bhaskar Gollapudi, Justin G. Teeguarden, Robert A. Budinsky, Lisa G. McFadden, Rudolph Valentine, Richard J. Albertini, Robert Fensterheim, Amanda Green, Thomas Lardie, David L. Rick, Leslie Recio, Mari Stavanja
Publikováno v:
Environmental and Molecular Mutagenesis. 54:755-768
Vinyl acetate monomer (VAM) produced rat nasal tumors at concentrations in the hundreds of parts per million. However, VAM is weakly genotoxic in vitro and shows no genotoxicity in vivo. A European Union Risk Assessment concluded that VAM's hydrolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24d72c5720ce3aa29d32bd616b67ea54
https://doi.org/10.1002/em.21809
https://doi.org/10.1002/em.21809
Autor:
Robert G. Ellis-Hutchings, Reza J. Rasoulpour, James S. Bus, Michael J. Bartels, M. Sue Marty, Claire Terry, Shakil A. Saghir, Richard Billington, David L. Rick, Alene T. McCoy, Jason P. Bailey
Publikováno v:
Regulatory Toxicology and Pharmacology. 63:321-332
Integrated toxicokinetics (TK) data provide information on the rate, extent and duration of systemic exposure across doses, species, strains, gender, and life stages within a toxicology program. While routine for pharmaceuticals, TK assessments of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107818a4cb48cd643a3f928f14a10276
https://doi.org/10.1016/j.yrtph.2012.03.004
https://doi.org/10.1016/j.yrtph.2012.03.004
Publikováno v:
Regulatory Toxicology and Pharmacology. 63:333-343
TK Modeler 1.0 is a Microsoft® Excel®-based pharmacokinetic (PK) modeling program created to aid in the design of toxicokinetic (TK) studies. TK Modeler 1.0 predicts the diurnal blood/plasma concentrations of a test material after single, multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc7a4f0295b1389b81e80d05ddc4e93
https://doi.org/10.1016/j.yrtph.2012.04.002
https://doi.org/10.1016/j.yrtph.2012.04.002
Autor:
Matthew J. LeBaron, David R. Geter, A. W. Perala, Fagen Zhang, Michael J. Bartels, Lynn Kan, David L. Rick
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:3123-3130
The possible interaction of environmental contaminants with the endocrine system has been an environmental concern since the early 1990s. To examine these interactions test guidelines have been introduced by regulatory agencies to screen for possible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26720c6dc4d48ef15af0ce9edea93794
https://doi.org/10.1002/rcm.5208
https://doi.org/10.1002/rcm.5208
Autor:
E Leibold, Xiaohua Qiu, George Cruzan, Ezra R. Lowe, David L. Rick, Michael J. Bartels, Fagen Zhang
Publikováno v:
Xenobiotica. 41:6-23
4-Vinylphenol (4VP) has been identified as a minor urinary metabolite of styrene in rat and human volunteers. This compound has been shown to be more hepatotoxic and pneumotoxic than both styrene and styrene oxide at lower doses in rats and mice. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb38e783d9318b2a634e8890606d8771
https://doi.org/10.3109/00498254.2010.523735
https://doi.org/10.3109/00498254.2010.523735
Autor:
E. L. McClymont, Fagen Zhang, David L. Rick, Michael J. Bartels, James S. Bus, Shakil A. Saghir
Publikováno v:
Toxicological Sciences. 107:352-366
This study was conducted to determine species differences in the metabolism of ethylbenzene (EB) in liver and lung. EB (0.22-7.0mM) was incubated with mouse, rat and human liver and lung microsomes and the formation of 1-phenylethanol (1PE), acetophe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e4fe1d5d46824d39cd58d5269052a
https://doi.org/10.1093/toxsci/kfn244
https://doi.org/10.1093/toxsci/kfn244
Autor:
David L. Rick, Shakil A. Saghir
Publikováno v:
Regulatory Toxicology and Pharmacology. 52:180-188
Methyl isobutyl ketone (MIBK) is a solvent used in numerous products and processes and may be present in the air of the workplace as a vapor. The American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value-time-weighted av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70454e2e00e3f887e7b6c5db82f7ea11
https://doi.org/10.1016/j.yrtph.2008.08.007
https://doi.org/10.1016/j.yrtph.2008.08.007
Publikováno v:
Bioremediation Journal. 5:79-92
Groundwater beneath a manufacturing site previously used for herbicide production has been shown to contain low levels of chlorinated phenols and phenoxy herbicides. The importance of biological processes in the natural attenuation of the groundwater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e61d2110babe38250d3555341942d5b
https://doi.org/10.1080/20018891079203
https://doi.org/10.1080/20018891079203
Publikováno v:
Regulatory Toxicology and Pharmacology. 58:170-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfefa562a0ac74b46b4a3d9bc42985e4
https://doi.org/10.1016/j.yrtph.2010.08.010
https://doi.org/10.1016/j.yrtph.2010.08.010