Zobrazeno 1 - 10
of 31
pro vyhledávání: '"David L. Pole"'
Autor:
David L. Pole
Publikováno v:
Journal of Pharmaceutical Sciences. 97:1071-1088
This review addresses the use of nonaqueous solvents as components of oral formulations in discovery and preclinical studies. Pharmacology, pharmacokinetic, and safety studies are frequently conducted with solution formulations that use a solvent to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d2aebae82764078552362d8c33a8e8
https://doi.org/10.1002/jps.21060
https://doi.org/10.1002/jps.21060
Publikováno v:
Molecular Pharmaceutics. 4:539-549
DELPHI is an expert system that has been developed to predict possible degradants of pharmaceutical compounds under stress testing conditions. It has been programmed with the objective of finding relevant degradation pathways, identifying degradant s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::150094c133ab4e538a0a37134006a747
https://doi.org/10.1021/mp060103+
https://doi.org/10.1021/mp060103+
Autor:
Roland Boese, John Warkentin, Armin de Meijere, Sergei I. Kozhushkov, Thomas Haumann, David L. Pole, Dmitry S. Yufit, Pradeep K. Sharma
Publikováno v:
Liebigs Annalen. 1996:601-612
The cycloaddition reactions of several dialkoxycarbenes generated in situ from the corresponding 2,2-dialkoxy-Δ3-1,3,4-oxadiazolines of the type 3 with bicyclopropylidene 1 afford the dialkyl acetals of dispiro[2.0.2.1]heptane-7-one (4), whereas the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bf11da44e81f3784bb870528eb0f79
https://doi.org/10.1002/jlac.199619960421
https://doi.org/10.1002/jlac.199619960421
Publikováno v:
Inorganic Chemistry. 37:4278-4283
The kinetics of formation of the silicate cubic octamer, Q(3)(8), in aqueous tetramethylammonium (TMA) silicate solutions was investigated by (29)Si NMR. The rate equation for solutions at pH 13.2-13.6 is d[Q(3)(8)]/dt = k(f) [H(+)](1.6)(+/-)(0.1)[TM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542fc840a40821f290601bca932cec87
https://doi.org/10.1021/ic971630d
https://doi.org/10.1021/ic971630d
Autor:
Lisa C. F. Chao, Stacey Brydges, James F. Britten, Michael J. McGlinchey, David L. Pole, Hari K. Gupta
Publikováno v:
Chemistry - A European Journal. 4:1201-1205
The first nondisordered structure of a free tropylium cation has been unequivocally determined by single-crystal X-ray diffraction. The solid-state structure of the heptaphenylcycloheptatrienyl cation, C7Ph7+, in [C7Ph7+][CF3CO2−]⋅2 CF3CO2H revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::554b27a83266d30008390a681ae0e0f5
https://doi.org/10.1002/(sici)1521-3765(19980710)4:7<1201::aid-chem1201>3.0.co
https://doi.org/10.1002/(sici)1521-3765(19980710)4:7<1201::aid-chem1201>3.0.co
Autor:
David L. Pole, Stacey Brydges, and Alex D. Bain, Michael J. McGlinchey, Suzie S. Rigby, Mark Stradiotto, Siden Top
Publikováno v:
The Journal of Organic Chemistry. 63:3735-3740
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a5fb460a45d2a7932305d8ae4a85a4f
https://doi.org/10.1021/jo9711504
https://doi.org/10.1021/jo9711504
Publikováno v:
Tetrahedron Letters. 38:5081-5084
Treatment of 1-diazo-3-(2-thienyl)-2-propanone with catalytic rhodium (II) acetate results in cyclopropanation followed by acid-catalyzed ring opening and tautomerization to yield 5,6-dihydro-4H-cyclopenta[b]thiopen-5-one. Under the same conditions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8181f8f3f8edc365f849724283cd7290
https://doi.org/10.1016/s0040-4039(97)01131-3
https://doi.org/10.1016/s0040-4039(97)01131-3
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1565-1570
The formal insertion of dimethoxycarbene (1a) into the acidic C–H bond of pentane-2,4-dione (9a), methyl acetoacetate (9b), 3-methylpentane-2,4-dione (9c) and 1,3-diphenylpropane-1,3-dione (9d) is reported as well as the insertion of 3-benzoyloxazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3126fd03f50bcc0b7c39cca49c7e12cc
https://doi.org/10.1039/a700169j
https://doi.org/10.1039/a700169j
Publikováno v:
Canadian Journal of Chemistry. 74:1480-1489
Four 2-methoxy-5,5-dimethyl-Δ3-1,3,4-oxadiazolines bearing an alkylthio or arylthio group at C2 were prepared. The oxadiazolines undergo thermolysis at 60–80 °C in solution to afford the corresponding oxythiocarbene intermediates. In the absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b6a0cba158576660fb329859e40cbdd
https://doi.org/10.1139/v96-165
https://doi.org/10.1139/v96-165
Publikováno v:
Canadian Journal of Chemistry. 74:1335-1340
Methoxy-(2-trimethylsilyl)ethoxycarbene reacts with two equivalents of dimethyl acetylene dicarboxylate, methyl propiolate, phenyl acetylene, or phenyl isocyanate without rearrangement of the carbene group. N-Phenylmaleimide captures the carbene with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5eecc5916ef050d8e4e213b6da19dfd
https://doi.org/10.1139/v96-149
https://doi.org/10.1139/v96-149