Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David L. McElligott"'
Autor:
David L. McElligott, Albert Lai, Alexandre Nesterov, Robert A. Mantei, T. Matthew Hansen, Peter de Vries, Arthur F. Kluge, Ronen Marmorstein, Michael R. Michaelides, Hong Liu, Kesicki Edward A, Kannan R. Karukurichi, J. William Langston, John H. Van Drie, Loren M. Lasko, Carmen Hertel, Michael A. Patane, Kenneth D. Bromberg, Ce Wang, Philip A. Cole, Roberto M. Risi
Publikováno v:
ACS Medicinal Chemistry Letters
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (H
Autor:
Lewis C. Cantley, Albert S. Yu, Kannan Karukarichi, Fredrik Karlsson, Ellen Santangelo, Rui Wang, F. Rahm, Ulrika Ericsson, Johan Linstrom, Mariell Pettersson, Jessica Martinsson, Tiago Braga, Madeleine Livendahl, Aine Brigette Henley, Horst Wähling, Lars Boukharta Persson, Martin Andersson, Tobias Ginman, Andreas Hoglund, Parisa Zolfaghari, Rickard Forsblom, Jenny Viklund, Lionel Trésaugues, David L. McElligott, Hyeseok Shim, Antoine Talagas, Tommy Johansson, Kesicki Edward A
Publikováno v:
Blood. 132:213-213
Phosphoinositide signaling is central to many cellular processes including the cell survival pathway known as autophagy. While there is evidence that autophagy can suppress tumorigenesis under certain circumstances, there is increasingly abundant evi
Autor:
Ruth L. Martin, Peter de Vries, Rohinton Edalji, T. Matt Hansen, Mikkel Algire, Fritz G. Buchanan, Wei Qiu, Brian T. Weinert, John H. Van Drie, Debra Ferguson, Kesicki Edward A, Ronen Marmorstein, Enrico L. Digiammarino, Philip A. Cole, Lloyd T. Lam, Chunaram Choudhary, Robin R. Frey, Loren M. Lasko, Roberto M. Risi, Kannan R. Karukurichi, Michael A. Patane, Debra Montgomery, Kenneth D. Bromberg, Bailin Shaw, Michael R. Michaelides, David L. McElligott, Arthur F. Kluge, J. William Langston, Ce Wang, Chaohong Sun, Vlasios Manaves, Emily J. Faivre, Maricel Torrent, Gary G. Chiang, Paul Hessler, Albert Lai, Saul H. Rosenberg, Clarissa G. Jakob, Tamar Uziel
Publikováno v:
Nature. 558:E1-E1
The dynamic and reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is a major epigenetic regulatory mechanism of gene transcription 1 associated with multiple diseases. While HDAC inhibi
Autor:
Graham Beaton, Phyllis Goldman, Edward A. Kesicki, Anthony J. Demaggio, Wilna J. Moree, Erik Christenson, John Eksterowicz, David L. Mcelligott, Dan Herendeen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5126-5129
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a ce
Publikováno v:
Cytogenetic and Genome Research. 64:240-244
Leukemia-inhibitory factor (LIF) and oncostatin M (OSM) are members of a family of structurally similar growth factors presenting overlapping and specific functions. Although the genes coding for IL-6, CSF3 and CNTF are scattered in the human and mou
Autor:
Olivier Civelli, James H. Eubanks, Glen A. Evans, David L. McElligott, Malek Djabali, Licia Selleri, David K. Grandy
Publikováno v:
Genomics. 14:1010-1018
The gene encoding the D2 dopamine receptor (DRD2) is located on human chromosome 11q23 and has been circumstantially associated with a number of human disorders including Parkinson's disease, schizophrenia, and susceptibility to alcoholism. To determ
Publikováno v:
Nucleic Acids Research. 19:4943-4948
Yeast artificial chromosomes (YACs) provide a powerful tool for the isolation and mapping of large regions of mammalian chromosomes. We developed a rapid and efficient method for the isolation of DNA fragments representing the extreme ends of YAC clo
Autor:
Dave LaFrenz, Jacqueline M. Glynn, Timothy J. Hale, Rosemary Rochford, Elton B Chu, Leonard I. Sweet, David L. Mcelligott, James E. Riggs, Bruce C. Richardson, Monte V. Hobbs, David N. Ernst
Publikováno v:
Cellular immunology. 220(1)
T cell proliferative responses decrease with age, but the mechanisms responsible are unknown. We examined the impact of age on memory and naive CD4(+) T cell entry and progression through the cell cycle using acridine orange to identify cell cycle st
Autor:
Marco Giovannini, James H. Eubanks, Licia Selleri, Gary G. Hermanson, Michael W. Smith, Susanne Maurer, Glen A. Evans, Anthony Romo, David L. McElligott, Malek Djabali
Publikováno v:
Genomics. 14(2)
"Chimeric" yeast artificial chromosomes (YACs) are clones containing two or more noncontiguous segments of DNA and represent the most common artifact found in total genomic YAC libraries currently used for large-scale genome mapping. These YACs creat
Autor:
David L. McElligott, Glen A. Evans
Publikováno v:
Genetic Engineering ISBN: 9781461365143
A major focus of modern molecular biology is the isolation and analysis of genes based upon associated phenotypes. The strategies for “positional cloning,” where a gene is cloned, analyzed and the basic underlying biology uncovered based upon its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9cb0c640aeebae7db922077838d69d9
https://doi.org/10.1007/978-1-4615-3424-2_15
https://doi.org/10.1007/978-1-4615-3424-2_15