Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David L. Lykins"'
Publikováno v:
International Journal of Molecular Sciences; Volume 16; Issue 11; Pages: 27208-27227
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27208-27227 (2015)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27208-27227 (2015)
The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidu
Autor:
James M. Roberts, Robert E. Ferrell, Marcia J. Gallaher, David L. Lykins, Mandy J. Schmella, Carl A. Hubel, Andrew D. Althouse
Publikováno v:
Biological Research For Nursing. 17:429-437
Maternal lipid metabolism undergoes a striking transformation during pregnancy, resulting in elevations in plasma triglycerides, cholesterol, and non-esterified fatty acids, with reversal postpartum (Herrera, 2002). Several factors related to estroge
Autor:
David L. Lykins, Robert W. Powers, Gail Harger, James M. Roberts, Hannele Laivuori, Michael Stephen Dunbar
Publikováno v:
Hypertension in Pregnancy. 24:49-58
We tested the hypothesis that twin pregnancies would lead to increased maternal plasma homocysteine. We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies witho
Autor:
Rebecca Troisi, William R. Crombleholme, James M. Roberts, Robert N. Hoover, Pentti K. Siiteri, Roberta B. Ness, Nancy Potischman, David L. Lykins
Publikováno v:
International Journal of Epidemiology. 32:455-460
Epidemiological studies show a substantially reduced risk of breast cancer in adult daughters of preeclamptic pregnancies, and modest risk reductions have been demonstrated for mothers also. Alterations in pregnancy hormone concentrations, particular
Autor:
Deborah Flotta, Sanjeev G. Shroff, James M. Roberts, Caroline Evans, Douglas Landsittel, Linda Gooch, Robert W. Powers, David L. Lykins
In subjects with previous preeclampsia, differences in cardiovascular and/or blood biochemical parameters are present in the nonpregnant state, and a simultaneous assessment of multiple derived indices better differentiates between women with or with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be965ac0b977c9e73730795b0c0e8890
https://europepmc.org/articles/PMC3139979/
https://europepmc.org/articles/PMC3139979/
Autor:
James M. Roberts, Robert W. Powers, Augustine Rajakumar, Eiji Shibata, Marcia J. Gallaher, Carl A. Hubel, David L. Lykins, Frauke von Versen-Höynck
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 291(5)
Reduced transport of amino acids from mother to fetus can lead to fetal intrauterine growth restriction (IUGR). The activities of several amino acid transport systems, including system A, are decreased in placental syncytiotrophoblast of IUGR pregnan
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 44(3)
Increased homocysteine is associated with the pregnancy complication preeclampsia and with later-life cardiovascular disease. Although elevated homocysteine persists after pregnancy, the vascular changes of preeclampsia abate with delivery, and cardi
Autor:
Alana K. Majors, Robert W. Powers, Kristine Y. Lain, Cynthia J. Sims, James M. Roberts, David L. Lykins
Publikováno v:
Metabolism: clinical and experimental. 51(11)
Homocysteine is an independent risk factor for peripheral vascular and coronary artery disease. The exact mechanism by which homocysteine promotes vascular dysfunction is unclear, but it is speculated to involve oxidative stress. Several studies have
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 28(5)
The pathogenesis of preeclampsia is proposed to be due to uncharacterized circulating factors that activate endothelial cells. Support for this hypothesis is provided by in vitro activation of endothelial cells by plasma from preeclamptic women, eg,
Publikováno v:
American journal of obstetrics and gynecology. 175(5)
In preeclampsia markers of endothelial activation (e.g., increased cellular fibronectin and activities that alter in vitro endothelial function (e.g., stimulation of nitric oxide and prostacyclin generation) are increased in the maternal circulation.