Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David L. Lin"'
Autor:
Mike Flint, Payel Chatterjee, David L. Lin, Laura K. McMullan, Punya Shrivastava-Ranjan, Éric Bergeron, Michael K. Lo, Stephen R. Welch, Stuart T. Nichol, Andrew W. Tai, Christina F. Spiropoulou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Genetic screens are important tools to identify host factors associated with viral infections. Here, Flint et al. perform a genome-wide CRISPR screen using infectious Ebola virus (EBOV) and show that the host transferase GNPTAB is required for EBOV i
Externí odkaz:
https://doaj.org/article/6d67096f29cf459880d85fa3e0fe6a72
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1666-1674.e4 (2019)
Summary: Although flaviviruses co-opt the function of the host endoplasmic reticulum (ER) membrane protein complex (EMC) during infection, a mechanistic explanation for this observation remains unclear. Here, we show that the EMC promotes biogenesis
Externí odkaz:
https://doaj.org/article/9febe1d429c84cf6855fe93b9a37b6de
Autor:
David L. Lin, German M. Traglia, Rachel Baker, David J. Sherratt, Maria Soledad Ramirez, Marcelo E. Tolmasky
Publikováno v:
Antibiotics, Vol 9, Iss 7, p 405 (2020)
Modules composed of a resistance gene flanked by Xer site-specific recombination sites, the vast majority of which were found in Acinetobacter baumannii, are thought to behave as elements that facilitate horizontal dissemination. The A. baumannii xer
Externí odkaz:
https://doaj.org/article/aeacdfe425f34d75ab0e43c1eb01af63
Autor:
David L. Lin, Natalia A. Cherepanova, Leonia Bozzacco, Margaret R. MacDonald, Reid Gilmore, Andrew W. Tai
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT Dengue virus (DENV) is the most common arboviral infection globally, infecting an estimated 390 million people each year. We employed a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen to identify host dep
Externí odkaz:
https://doaj.org/article/471ad4d8a7494c59835c814f42af254b
Autor:
David L. Lin, Varun N. Kapoor, Naruhisa Ota, Joseph Chavarria-Smith, Christian Cox, Menno van Lookeren Campagne, Travis W. Bainbridge, Noelyn M. Kljavin, Keith R. Anderson, Joseph R. Arron, Frederic J. de Sauvage, Shannon J. Turley, Yun Li, Søren Warming, Elaine E. Storm, Lifen Wang, Merone Roose-Girma
Publikováno v:
Science Immunology. 6
Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs to be local and proportional to the insult. How different types of damage are coupled to repair remains incompletely understo
Autor:
Michael K. Lo, Stuart T. Nichol, Mike Flint, Stephen R. Welch, Andrew W. Tai, Punya Shrivastava-Ranjan, Christina F. Spiropoulou, Eric Bergeron, Laura K. McMullan, Payel Chatterjee, David L. Lin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Ebola virus (EBOV) infection. We identify GNPTAB, which encodes the α and β subunits of N-acetylgluc
Autor:
German Matias Traglia, David J. Sherratt, Marcelo E. Tolmasky, David L. Lin, Rachel Baker, Maria Soledad Ramirez
Publikováno v:
Antibiotics
Volume 9
Issue 7
Antibiotics, Vol 9, Iss 405, p 405 (2020)
Volume 9
Issue 7
Antibiotics, Vol 9, Iss 405, p 405 (2020)
Modules composed of a resistance gene flanked by Xer site-specific recombination sites, the vast majority of which were found in Acinetobacter baumannii, are thought to behave as elements that facilitate horizontal dissemination. The A. baumannii xer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5bc7f9f3182ff65d681c0b7b550701
Autor:
Rachel Baker, David J. Sherratt, Marcelo E. Tolmasky, German Matias Traglia, David L. Lin, Maria Soledad Ramirez
Modules composed of a resistance gene flanked by Xer site-specific recombination sites, the vast majority of which were found in Acinetobacter baumannii, are thought to behave as elements that facilitate horizontal dissemination. The A. baumannii xer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985737834c8cfd410e32716d5a38885b
https://doi.org/10.20944/preprints202006.0163.v1
https://doi.org/10.20944/preprints202006.0163.v1
Autor:
Saumya Jani, Madeline E. Rasche, Kevin Chiem, David L. Lin, Brooke A. Fuentes, Marcelo E. Tolmasky
Publikováno v:
MedChemComm. 7:184-189
The aminoglycoside 6′-N-acetyltransferase type Ib, AAC(6′)-Ib, confers resistance to clinically relevant aminoglycosides and is the most widely distributed enzyme among AAC(6′)-I-producing Gram-negative pathogens. An alternative to counter the
Autor:
Radleigh G. Santos, Marc A. Giulianotti, Saumya Jani, Kevin Chiem, Veronica Jimenez, Marcelo E. Tolmasky, David L. Lin, Rupali Lad, Ginamarie Debevec, Mary B. Farone, Brock A. Arivett, Clemencia Pinilla, Tung Tran
The aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6’)-Ib] is the most widely distributed enzyme among AAC(6’)-I-producing Gram-negative pathogens and confers resistance to clinically relevant aminoglycosides including amikacin. This enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c516c22a66b2c2bcbf2af023b31fb5b