Zobrazeno 1 - 10
of 127
pro vyhledávání: '"David L. Hachey"'
Autor:
Melissa N. Martinez, Christopher H. Emfinger, Matthew Overton, Salisha Hill, Tara S. Ramaswamy, David A. Cappel, Ke Wu, Sergio Fazio, W. Hayes McDonald, David L. Hachey, David L. Tabb, John M. Stafford
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 3, Pp 379-389 (2012)
Mechanisms underlying changes in HDL composition caused by obesity are poorly defined, partly because mice lack expression of cholesteryl ester transfer protein (CETP), which shuttles triglyceride and cholesteryl ester between lipoproteins. Because m
Externí odkaz:
https://doaj.org/article/be230677c69d40ba923e39e0de70e324
Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome
Autor:
Michael V. Morabito, Atheir I. Abbas, Jennifer L. Hood, Robert A. Kesterson, Michelle M. Jacobs, David S. Kump, David L. Hachey, Bryan L. Roth, Ronald B. Emeson
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 2, Pp 169-180 (2010)
RNA transcripts encoding the 2C-subtype of serotonin (5HT2C) receptor undergo up to five adenosine-to-inosine editing events to encode twenty-four protein isoforms. To examine the effects of altered 5HT2C editing in vivo, we generated mutant mice sol
Externí odkaz:
https://doaj.org/article/a3f569d7de2e4b4798f5df34f527274b
Autor:
Natalie E. Freeman, Antonio E. Rusinol, MacRae Linton, David L. Hachey, Sergio Fazio, Michael S. Sinensky, Douglas Thewke
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 9, Pp 1933-1943 (2005)
7-Ketocholesterol (7KC) is a cytotoxic component of oxidized low density lipoproteins (OxLDLs) and induces apoptosis in macrophages by a mechanism involving the activation of cytosolic phospholipase A2 (cPLA2). In the current study, we examined the r
Externí odkaz:
https://doaj.org/article/4aca7ee1b25446188eb539b179a21c6b
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 11, Pp 2118-2124 (1999)
Assessment of free fatty acid (FFA) concentration and isotopic enrichment is useful for studies of FFA kinetics in vivo. A new procedure to recover the major FFA from plasma for concentration and isotopic enrichment measurements is described and vali
Externí odkaz:
https://doaj.org/article/0de1e38b1e9e47d6abb2c429a1bac457
Autor:
Mace L. Rothenberg, Jordan D. Berlin, John A. Hartley, Chih-Yi Liao, Victoria J. Spanswick, Wendy L. Vermeulen, David L. Hachey, M. Wade Calcutt, Alice P. Chen, Wooin Lee, Igor Puzanov
Supplementary Figures S1-S2; Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b33f7dc6d4b5b33f301b098ec83fff
https://doi.org/10.1158/1078-0432.22442820
https://doi.org/10.1158/1078-0432.22442820
Autor:
Mace L. Rothenberg, Jordan D. Berlin, John A. Hartley, Chih-Yi Liao, Victoria J. Spanswick, Wendy L. Vermeulen, David L. Hachey, M. Wade Calcutt, Alice P. Chen, Wooin Lee, Igor Puzanov
Purpose: This phase I study assessed the maximum tolerated dose (MTD), safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of SJG-136, a sequence-specific DNA cross-linking agent, in patients with advanced cancer.Experimental Desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb5972f54cb43497270d4bd56717e6c
https://doi.org/10.1158/1078-0432.c.6519480
https://doi.org/10.1158/1078-0432.c.6519480
Publikováno v:
Experimental Eye Research. 149:59-65
In the human ocular lens it is now realized that post-translational modifications can alter protein function and/or localization in fiber cells that no longer synthesize proteins. The specific sites of post-translational modification to the abundant
Autor:
Jonathan H. Sheehan, David L. Hachey, Robert J. Matusik, Philip D. Anderson, David W. Piston, Hironobu Yamashita, David B. Friedman, Jung-Mo Ahn, David J. DeGraff, Xiuping Yu, Ganesh V. Raj, Qian Sun, Magdalena M. Grabowska, Amicia D. Elliott, Govindaraj Anumanthan, Richard M. Gronostajski
Publikováno v:
Molecular Endocrinology. 28:949-964
Androgen receptor (AR) action throughout prostate development and in maintenance of the prostatic epithelium is partly controlled by interactions between AR and forkhead box (FOX) transcription factors, particularly FOXA1. We sought to identity addit
Autor:
Kristie L. Rose, Steven Steele, Theresa J. Rogers, M. Wade Calcutt, Judy L. Aschner, David L. Hachey, Amy B. Beller, Salisha Hill, David C. Ehrmann
Publikováno v:
Journal of Mass Spectrometry. 49:178-183
Oxidative stress plays an important role in the development of various disease processes and is a putative mechanism in the development of bronchopulmonary dysplasia, the most common complication of extreme preterm birth. Glutathione, a major endogen
Autor:
David L. Hachey
Few discoveries in nature have enhanced scientific progress or achieved such widespread utility as have isotopes. Examples of their use can now be found in all the basic and biomedical sciences and with increasing frequency in such diverse discipline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b5f45f72f444229eca69e699a2cfe5
https://doi.org/10.1016/b978-0-08-043848-1.00041-9
https://doi.org/10.1016/b978-0-08-043848-1.00041-9