Zobrazeno 1 - 10
of 46
pro vyhledávání: '"David L. Greenman"'
Publikováno v:
Toxicologic Pathology. 23:241-247
The system for assigning cause of death in animal studies of carcinogenicity at the National Center for Toxicological Research (NCTR) is described. An empirical study of the NCTR's experience with its current cause-of-death assignment system based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f039a149a005466ce9b4b3d6921aa7b5
https://doi.org/10.1177/019262339502300301
https://doi.org/10.1177/019262339502300301
Publikováno v:
Journal of the American College of Toxicology. 14:148-157
The chronic toxicity and carcinogenicity of pyrilamine maleate were evaluated in B6C3F1 mice by feeding for up to 2 years to groups of 60 male or female mice at dietary levels of 0,150, 750, or 1,500 ppm (as the free base). Up to 12 mice per sex and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c1cc32cac31c73fcc6388e303e153e0
https://doi.org/10.3109/10915819509008688
https://doi.org/10.3109/10915819509008688
Publikováno v:
Fundamental and Applied Toxicology. 25:1-8
The antihistamine, pyrilamine maleate, was fed for up to 2 years to groups of 57 Fischer 344 (F344) rats of each sex at dietary levels of 0, 300, 1500, or 3000 ppm (free base). Eight or nine of these rats per sex and dose group were killed at 65 week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c26b51c11aeb33f9a933c625bc00a93
https://doi.org/10.1006/faat.1995.1034
https://doi.org/10.1006/faat.1995.1034
Autor:
William T. Allaben, G.J. Schieferstein, Winslow G. Sheldon, Richard R. Allen, David L. Greenman
Publikováno v:
Toxicological Sciences. 27:223-231
The antihistamine triprolidine hydrochloride, was fed at dietary concentrations of 0, 250, 1000, or 2000 ppm (as the free base) to groups of 60 Fischer 344 (F344) rats of each sex for up to 2 years to evaluate its potential carcinogenicity. Up to 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002b7a42164a779779002bcea3c067ef
https://doi.org/10.1093/toxsci/27.2.223
https://doi.org/10.1093/toxsci/27.2.223
Autor:
David L. Greenman, William T. Allaben, Winslow G. Sheldon, Richard R. Allen, G.J. Schieferstein
Publikováno v:
Toxicological Sciences. 25:138-145
Chronic Study of Triprolidine for Oncogenicity in Mice. Greenman, D. L., Sheldon, W., Schieferstein, G., Allen, R., and Allaben, W. T. (1995). Fundam. Appl. Toxicol. 25, 138-145. Triprolidine hydrochloride was fed to groups of 60 B6C3F1 mice per sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a221a95d23a29ef36622d036790d7
https://doi.org/10.1093/toxsci/25.1.138
https://doi.org/10.1093/toxsci/25.1.138
Publikováno v:
Journal of the American College of Toxicology. 12:337-345
The purpose of this study was to determine the effects of subchronic exposure to the antihistamine pyrilamine maleate and to establish dosage levels to use in a 2-year chronic study. A 14-day repeated-dose study in male and female B6C3F1 mice at diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::310b330a8f57a7972f8f27712ac89d81
https://doi.org/10.1177/109158189301200404
https://doi.org/10.1177/109158189301200404
Publikováno v:
Journal of the American College of Toxicology. 12:175-183
This study was designed to determine the subchronic effects of the antihistamine, pyrilamine maleate, and to establish dose levels for a 2-year chronic study. Six male and six female F344 rats received dietary pyrilamine concentrations of 0, 392, 783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8802cfa42ab01d6b290c1684d0cd3759
https://doi.org/10.3109/10915819309140637
https://doi.org/10.3109/10915819309140637
Publikováno v:
Fundamental and Applied Toxicology. 16:51-60
Diet is a major influence on the responses of experimental animals to drugs, toxins, and carcinogens. Two diets used widely in toxicological and carcinogenic studies, and considered to be nutritionally adequate, were compared with respect to neoplast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa6fd747e6f7f6b0bf632a8a6286776
https://doi.org/10.1016/0272-0590(91)90134-p
https://doi.org/10.1016/0272-0590(91)90134-p
Publikováno v:
Journal of Toxicology and Environmental Health. 29:269-278
Diethylstilbestrol (DES) was fed chronically to C57BL/6 mice at concentrations of 0, 5, 10, 20, 40, 160, 320, or 640 ppb in order to define the dose-response curve for neoplastic responses. The incidence of thyroid follicular cell adenomas was higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34acc70c47108b7ddb18a18759fda215
https://doi.org/10.1080/15287399009531390
https://doi.org/10.1080/15287399009531390
Publikováno v:
Carcinogenesis. 14(6)
The interactive effects of dietary methyl insufficiency and the estrogenic compound ethynylestradiol (EE) on the levels of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) were examined in the liver, lungs and pancreas of rats. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b10cb4d471caf7de1c2811be91f630
https://pubmed.ncbi.nlm.nih.gov/8508512
https://pubmed.ncbi.nlm.nih.gov/8508512