Zobrazeno 1 - 10
of 85
pro vyhledávání: '"David L. Farrens"'
Autor:
Seksiri Arttamangkul, Andrew Plazek, Emily J Platt, Haihong Jin, Thomas F Murray, William T Birdsong, Kenner C Rice, David L Farrens, John T Williams
Publikováno v:
eLife, Vol 8 (2019)
Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluores
Externí odkaz:
https://doaj.org/article/afd221fdbb4c475bbda925ce0c8607b0
Publikováno v:
J Biol Chem
Rhodopsin is a canonical class A photosensitive G protein–coupled receptor (GPCR), yet relatively few pharmaceutical agents targeting this visual receptor have been identified, in part due to the unique characteristics of its light-sensitive, coval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2679cdd59335dd06ec9bee3e9f3383fa
https://doi.org/10.1074/jbc.ra120.014631
https://doi.org/10.1074/jbc.ra120.014631
Publikováno v:
Biophys J
Biophysical journal, vol 120, iss 20
Biophysical journal, vol 120, iss 20
Styrene-maleic acid (SMA) copolymers solubilize biological membranes to form lipid nanoparticles (SMALPs) that contain membrane proteins surrounded by native lipids, thus enabling the use of a variety of biophysical techniques for structural and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca87aaf5a7b1bab796fb6089a3c00aef
https://europepmc.org/articles/PMC8553795/
https://europepmc.org/articles/PMC8553795/
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Class A G-protein-coupled receptors (GPCRs) normally function as monomers, although evidence from heterologous expression systems suggests that they may sometimes form homodimers and/or heterodimers. This study aims to evaluate possible functional in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641e4665ab655fa22130f7f702adbdc5
https://doi.org/10.7554/elife.69740
https://doi.org/10.7554/elife.69740
Autor:
Jonathan F. Fay, Anthony D. Shumate, Eefei Chen, Stephanie G. Pitch, Weekie Yao, Istvan Szundi, David L. Farrens, David S. Kliger
Publikováno v:
Biophys J
Biophysical journal, vol 120, iss 16
Biophysical journal, vol 120, iss 16
Membrane proteins often require solubilization to study their structure or define the mechanisms underlying their function. In this study, the functional properties of the membrane protein rhodopsin in its native lipid environment were investigated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb6c1661d08c2a5bc5ca6a1d4c4b0dc
https://europepmc.org/articles/PMC8391062/
https://europepmc.org/articles/PMC8391062/
Autor:
Thomas F. Murray, Andrew Plazek, David L. Farrens, Seksiri Arttamangkul, Emily J. Platt, John T. Williams, Haihong Jin, Kenner C. Rice, William T. Birdsong
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d743acb98057d00e42b9eebdd2b650e
https://doi.org/10.7554/elife.49319
https://doi.org/10.7554/elife.49319
Autor:
Haihong Jin, David L. Farrens, John T. Williams, Emily J. Platt, William T. Birdsong, Andrew Plazek, Thomas F. Murray, Seksiri Arttamangkul, Kenner C. Rice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5c458a8df54043a591f39d682e69ea
https://doi.org/10.7554/elife.49319.028
https://doi.org/10.7554/elife.49319.028
Publikováno v:
BIOPHYSICAL JOURNAL, vol 118, iss 3
Author(s): Pitch, Stephanie G; Szundi, Istvan; Yao, Weekie; Chen, Eefei; Farrens, David L; Kliger, David S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ca17d25b2c409d934eb80d51fc36ff
https://doi.org/10.1016/j.bpj.2019.11.2082
https://doi.org/10.1016/j.bpj.2019.11.2082
Publikováno v:
Biophysical Journal. 118:94a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff0e3c6970001c9bdf9a0720c1eae578
https://doi.org/10.1016/j.bpj.2019.11.678
https://doi.org/10.1016/j.bpj.2019.11.678
Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs
Autor:
Samuel M. Walsh, Signe Mathiasen, David L. Farrens, Søren G. F. Rasmussen, Brian K. Kobilka, Dimitrios Stamou, Davide Provasi, Christopher King, Marta Filizola, Ernesto E. Borrero, Jonathan F. Fay, Sune M. Christensen, Juan Jose Fung, Kalina Hristova
Publikováno v:
Biophysical journal. 115(2)
G-protein-coupled receptors (GPCRs) control vital cellular signaling pathways. GPCR oligomerization is proposed to increase signaling diversity. However, many reports have arrived at disparate conclusions regarding the existence, stability, and stoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8875848af8933743cf53eea8b2bea9fb
https://pubmed.ncbi.nlm.nih.gov/30021106
https://pubmed.ncbi.nlm.nih.gov/30021106