Výsledky vyhledávání - "David L. Coffen"

The Integration of High Throughput Technologies for Drug Discovery

Autor: David L. Coffen, Gregory P. Sabbatini, William A. Shirley

Publikováno v: SLAS Discovery. 6:213-218

Producing quality clinical candidates less prone to late stage failure is greatly facilitated by better integration of the relevant high throughput functions and the inclusion of ADME/toxicology further upstream in the discovery process. We describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055c0efe904107dadb20ed4c41bc3ccb
https://doi.org/10.1177/108705710100600402

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Automated parallel synthesis of chalcone-based screening libraries

Autor: Jonah R. Troth, David S. Casebier, William J. Ryan, Demosthenes Fokas, David L. Coffen, David G. Powers

Publikováno v: Tetrahedron. 54:4085-4096

Using a variety of condensation and cyclization reactions, nine combinatorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 μM quantities. The ease with which a broad range of diversity can be fabricated around a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77f6a30de9b0a1b802d30faaf9ac06f1
https://doi.org/10.1016/s0040-4020(98)00137-9

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Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis

Autor: Christopher J. Verni, Robert J. Tarsa, Adrian Sheldon, David L. Coffen, Carmen M. Baldino, Gary Gustafson, Mary-Margaret O’Donnell

Publikováno v: Tetrahedron. 54:4051-4065

A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd04f6c8d312812d1c8e6714ae0cbcb8
https://doi.org/10.1016/s0040-4020(98)00134-3

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Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reaction

Autor: David S. Casebier, David L. Coffen, William J. Ryan, Demosthenes Fokas

Publikováno v: Tetrahedron Letters. 39:2235-2238

A combinatorial library of 26,500 spiro[pyrrolidine-2,3′-oxindoles] was prepared in a single-compound format by a facile intermolecular 1,3-dipolar cycloaddition. An azomethine ylide, generated by the decarboxylative condensation of an isatin 1 wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfa70aebcb9daba8b9edbc281cf16278
https://doi.org/10.1016/s0040-4039(98)00234-2

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Enzymic enhancement of n−3 fatty acid content in fish oils

Autor: Gladys Zenchoff, Hubert Maehr, David L. Coffen

Publikováno v: Journal of the American Oil Chemists' Society. 71:463-467

Commercially available fish oils with n−3 fatty acid contents ranging from 29 to 34% were converted enzymically, with Amano P lipase, to mixtures of glycerides with n−3 fatty acid contents ofca. 50%, in weight recovery yields of 23–50%, dependi

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https://doi.org/10.1007/bf02540654

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Synthesis of a biologically active vitamin D2 metabolite

Autor: Percy S. Manchand, David L. Coffen, Lucia Serico, Satish C. Choudhry, Peter S. Belica, Antonino Focella, Hubert Maehr, Roxana Yang

Publikováno v: The Journal of Organic Chemistry. 58:1496-1500

The synthesis of 1α,25,28-trihydroxyvitamin-D 2 (1) from vitamin-D 2 is described. The synthesis involves three key features:() the dissection of the vitamin-D2 side chain, (ii) C-1 hydroxylation, and (iii) the preparation and introduction of the ap

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https://doi.org/10.1021/jo00058a034

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Synthesis and evaluation of retinal Schiff base salts and related compounds as radar absorbing agents

Autor: Thomas H. Williams, Wayne S. Hammond, Thomas R. Wagler, David L. Coffen, Gino J. Sasso, Voldemar Toome, Larry E. Nitzsche, Eugene Ho, Carlo Nocka

Publikováno v: Journal f�r Praktische Chemie/Chemiker-Zeitung. 335:135-142

Thirteen Schiff base salts in the class of compounds represented by retinal pyrrolidinium perchlorate were prepared (most of them for the first time), fully characterized analytically and spectroscopically, and examined in the 30–100 GHz range with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c880f5bc6147ef89b95a809b77a9ed0
https://doi.org/10.1002/prac.19933350204

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