Výsledky vyhledávání - "David L. Carbone"

CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice

Autor: David L. Carbone, Damian G. Zuloaga, Robert J. Handa, Mario G. Oyola, Shaila K. Mani, Alexandra Acevedo-Rodriguez, Anna M. Malysz

Publikováno v: Endocrinology. 156:2150-2161

In addition to androgenic properties mediated via androgen receptors, dihydrotestosterone (DHT) also regulates estrogenic functions via an alternate pathway. These estrogenic functions of DHT are mediated by its metabolite 5α-androstane-3β, 17β-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220c617051131a0453483156d22c062e
https://doi.org/10.1210/en.2014-1786

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Estrogen receptor β expression in the mouse forebrain: Age and sex differences

Autor: Robert J. Handa, Damian G. Zuloaga, Kristen L. Zuloaga, Laura R. Hinds, David L. Carbone

Publikováno v: Journal of Comparative Neurology. 522:358-371

Estrogen receptors regulate multiple brain functions, including stress, sexual, and memory-associated behaviors as well as controlling neuroendocrine and autonomic function. During development, estrogen signaling is involved in programming adult sex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7475bf7acc5c5417edc6a2c04476097f
https://doi.org/10.1002/cne.23400

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Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor

Autor: Robert J. Handa, David L. Carbone

Publikováno v: Neuroscience. 239:295-303

The neurotrophin, brain-derived neurotrophic factor (BDNF), is recognized as a key component in the regulation of central nervous system ontogeny, homeostasis and adult neuroplasticity. The importance of BDNF in central nervous system development and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad6d9dabe28d2f59d23ebad89879d8d
https://doi.org/10.1016/j.neuroscience.2012.10.073

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Exposure to dexamethasone during late gestation causes female-specific decreases in core body temperature and prepro-thyrotropin-releasing hormone expression in the paraventricular nucleus of the hypothalamus in rats

Autor: Robert F. McGivern, Robert J. Handa, David L. Carbone, Anthony F. Lacagnina, Damian G. Zuloaga

Publikováno v: Physiology & Behavior. 108:6-12

Synthetic glucocorticoids (GC) have been used to promote lung development in preterm infants, thereby decreasing respiratory distress syndrome and mortality, yet, concern has arisen from reports that such treatment predisposes individuals to disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a68ef2d417a45bb299ec6e8b24e4c90
https://doi.org/10.1016/j.physbeh.2012.07.010

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In Vitro and in Silico Characterization of Peroxiredoxin 6 Modified by 4-Hydroxynonenal and 4-Oxononenal

Autor: James R. Roede, Philip Reigan, Jonathan A. Doorn, Dennis R. Petersen, Oleg V. Kirichenko, David L. Carbone

Publikováno v: Chemical Research in Toxicology. 21:2289-2299

Peroxiredoxin 6 (PRX6) belongs to the 1-Cys class of peroxiredoxins and is recognized as an important antioxidant protein in tissues such as cardiac muscle, skin, and lung. Preliminary in vivo proteomic data have revealed that PRX6 is adducted by 4-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a564014ef8dbb29b88f98d83c06eb184
https://doi.org/10.1021/tx800244u

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Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

Autor: Julie A. Moreno, Stephen Safe, David L. Carbone, Katriana A. Popichak, Ronald B. Tjalkens

Publikováno v: Molecular Pharmacology. 75:35-43

The progressive debilitation of motor functions in Parkinson's disease (PD) results from degeneration of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. Long-term inflammatory activation of microglia and astrocytes pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3403326f464c2c2dabb016c84922240
https://doi.org/10.1124/mol.108.050781

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4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est–Like Protein-1-Activating Protein-1 Signal Transduction

Autor: Derek A. Drechsel, David L. Carbone, Jonathan A. Doorn, Brante P. Sampey, Dennis R. Petersen

Publikováno v: Molecular Pharmacology. 71:871-883

4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation (LPO) product formed during oxidative stress. 4-HNE is highly reactive toward cellular nucleophiles and is implicated in the evolution of numerous pathologies associated with oxidative stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f234f933bc9578a55cb5de921403343e
https://doi.org/10.1124/mol.106.029686

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Inhibition of Hsp72-Mediated Protein Refolding by 4-Hydroxy-2-nonenal

Autor: Zachary Kiebler, Jonathan A. Doorn, Brante P. Sampey, Dennis R. Petersen, David L. Carbone

Publikováno v: Chemical Research in Toxicology. 17:1459-1467

A proteomic approach was applied to liver cytosol from rats fed a diet consisting of high fat and ethanol to identify 4-hydroxy-2-nonenal (4-HNE)-modified proteins in vivo. Cytosolic Hsp72, the inducible variant of the Hsp70 heat shock protein family

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f034914ab70e910893e49ecf5eca56b5
https://doi.org/10.1021/tx049838g

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