Informed consent and risk communication challenges in antimicrobial clinical trials: a scoping review

Autor: Yin Mo, Yiyun Shou, Joey Elizabeth Yeo, Alexander Shao-Rong Pang, David L. Paterson

Publikováno v: BMJ Open, Vol 14, Iss 11 (2024)

Objectives Randomised trials for the management of drug-resistant infections are challenging to conduct as target patient populations often lack decision-making capacity, and enrolment windows are typically short. Improving informed consent and risk

Externí odkaz: https://doaj.org/article/671ed73738c349be827963ba07f48cc8

Mortality, hospital length of stay, and recurrent bloodstream infections associated with extended-spectrum beta-lactamase-producing Escherichia coli in a low prevalence region: A 20-year population-based large cohort study

Autor: Weiping Ling, David L. Paterson, Patrick N.A. Harris, Luis Furuya-Kanamori, Felicity Edwards, Kevin B. Laupland

Publikováno v: International Journal of Infectious Diseases, Vol 138, Iss , Pp 84-90 (2024)

Objectives: This population-based study aimed to investigate the risk factors and effect of extended-spectrum beta-lactamase (ESBL) production on clinical outcomes in Escherichia coli bloodstream infection (BSI) patients. Methods: The study populatio

Externí odkaz: https://doaj.org/article/75b22d39541e40d68462bd37f3dd8718

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

Autor: Patrick N. A. Harris, Michelle J. Bauer, Lukas Lüftinger, Stephan Beisken, Brian M. Forde, Ross Balch, Menino Cotta, Luregn Schlapbach, Sainath Raman, Kiran Shekar, Peter Kruger, Jeff Lipman, Seweryn Bialasiewicz, Lachlan Coin, Jason A. Roberts, David L. Paterson, Adam D. Irwin

Publikováno v: Microbiology Spectrum, Vol 12, Iss 2 (2024)

ABSTRACTWe aimed to evaluate the performance of Oxford Nanopore Technologies (ONT) sequencing from positive blood culture (BC) broths for bacterial identification and antimicrobial susceptibility prediction. Patients with suspected sepsis in four int

Externí odkaz: https://doaj.org/article/aefbffbf2f2b44a2b26a2a37843d1f63

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Autor: Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a

Externí odkaz: https://doaj.org/article/6d65b18b91de403488fe5eca204df6be

In vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam monotherapy with ceftazidime-avibactam-containing combination regimens against carbapenem-resistant Enterobacterales and multidrug-resistant Pseudomonas aeruginosa isolates or infections: a scoping review

Autor: Abdullah Tarık Aslan, Yukiko Ezure, Juan Pablo Horcajada, Patrick N. A. Harris, David L. Paterson

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

IntroductionCarbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro, in vivo and clinic

Externí odkaz: https://doaj.org/article/3ff4124ff7a24c4199ec2ef397b6907c