Zobrazeno 1 - 10
of 78
pro vyhledávání: '"David L Wokosin"'
Autor:
Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Publikováno v:
eLife, Vol 8 (2019)
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://doaj.org/article/6d433a31aa0f4103a04bf72732b8b59c
Publikováno v:
eLife, Vol 6 (2017)
Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that this spiking mode depends upon an interaction between synaptic activat
Externí odkaz:
https://doaj.org/article/4560a5b3996748758ac4985a347bc5db
Autor:
Jeremy F Atherton, Eileen L McIver, Matthew RM Mullen, David L Wokosin, D James Surmeier, Mark D Bevan
Publikováno v:
eLife, Vol 5 (2016)
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To
Externí odkaz:
https://doaj.org/article/1ce7a2909744475281264f266529e3b2
Autor:
Deepak P Srivastava, Kevin M Woolfrey, Kelly A Jones, Charles T Anderson, Katharine R Smith, Theron A Russell, Hyerin Lee, Marina V Yasvoina, David L Wokosin, P Hande Ozdinler, Gordon M G Shepherd, Peter Penzes
Publikováno v:
PLoS Biology, Vol 10, Iss 6, p e1001350 (2012)
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computational properties of neurons, and dendritic structure is impaired in several psychiatric disorders. While apical and basal dendritic compartments of py
Externí odkaz:
https://doaj.org/article/82bebeeb8c44423d9a906dbfb32001e3
Autor:
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. Wokosin, Patricia González-Rodríguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s d
Externí odkaz:
https://doaj.org/article/9f3da2a974ae4bf7836154aa87353185
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Methamphetamine (meth) is an addictive psychostimulant and illicit use presents significant personal and socioeconomic harm. Behavioral studies support the involvement of the dorsal striatum in drug-seeking but stimulant induced dysfunction
Externí odkaz:
https://doaj.org/article/9ca35ed49e6949b7930fb72822d81ad2
Autor:
Enrico, Zampese, David L, Wokosin, Patricia, Gonzalez-Rodriguez, Jaime N, Guzman, Tatiana, Tkatch, Jyothisri, Kondapalli, William C, Surmeier, Karis B, D'Alessandro, Diego, De Stefani, Rosario, Rizzuto, Masamitsu, Iino, Jeffery D, Molkentin, Navdeep S, Chandel, Paul T, Schumacker, D James, Surmeier
Publikováno v:
Science advances. 8(39)
How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of speculation, this coupling is still poorly understood, particularly in neurons that are tonically
Publikováno v:
J Neurosci
The debilitating psychomotor symptoms of Huntington's disease (HD) are linked partly to degeneration of the basal ganglia indirect pathway. At early symptomatic stages, before major cell loss, indirect pathway neurons exhibit numerous cellular and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deda6d43d9b1f955b2ca4d93bfa6c269
https://europepmc.org/articles/PMC8916764/
https://europepmc.org/articles/PMC8916764/
Autor:
Patricia González-Rodríguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, José López-Barneo, Paul T. Schumacker, D. James Surmeier
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
In the version of this article initially published, the two bottom-left panels in Extended Data Fig. 8b duplicated the top-left and bottom-right panels of Fig. 4d presenting open field traces in mice. The panels have now been replaced with new images
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc515790d312c278eea0bb85f26bfc7
https://www.nature.com/articles/s41586-021-04382-6.pdf
https://www.nature.com/articles/s41586-021-04382-6.pdf
Autor:
Ben Yang, Ema Ilijic, Kristen A. Stout, José López-Barneo, David L. Wokosin, Michael G. Kaplitt, Jaime N. Guzman, Enrico Zampese, D. James Surmeier, Lin Gao, Paul T. Schumacker, Patricia González-Rodríguez, Mihaela Stavarache, Tatiana Tkatch
Publikováno v:
Nature
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson’s disease1. Yet, whether this change contributes to Parkinson’s disease pathogenesis is unclear2. Here we used interse